Matrix metalloproteinase-1 decorated polymersomes, a surface-active extracellular matrix therapeutic, potentiates collagen degradation and attenuates early liver fibrosis

Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications

(2020) Shoaib Iqbal et al.   BIOMACROMOLECULES

Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases

(2020) Eline Geervliet et al.   Cells

Fibroblast growth factor 2 conjugated superparamagnetic iron oxide nanoparticles (FGF2-SPIONs) ameliorate hepatic stellate cells activation in vitro and acute liver injury in vivo

(2020) Dhadhang Wahyu Kurniawan et al.   JOURNAL OF CONTROLLED RELEASE

Toward Functional Synthetic Cells: In-Depth Study of Nanoparticle and Enzyme Diffusion through a Cross-Linked Polymersome Membrane

(2019) Hannes Gumz et al.   Advanced Science

TG101348, a selective JAK2 antagonist ameliorates hepatic fibrogenesis in vivo

(2019) Büsra Öztürk Akcora et al.   FASEB JOURNAL

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets

(2019) Noriko Itaba et al.   Scientific Reports

Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis

(2019) Maximilian Joseph Brol et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy

(2019) Qian-Qian Fan et al.   BIOMATERIALS

Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12

(2018) Büsra Öztürk Akcora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads

(2018) Ziqiang Sun et al.   BIOMACROMOLECULES

Clinical and Economic Burden of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Zobair M. Younossi et al.   Clinics in Liver Disease

Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors

(2018) Hailong Che et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Wavelength-Selective Light-Responsive DASA-Functionalized Polymersome Nanoreactors

(2018) Omar Rifaie-Graham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Matrix metalloproteinase functions in hepatic injury and fibrosis

(2018) Martin Roderfeld   MATRIX BIOLOGY

Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process

(2018) Robert Ccorahua et al.   RSC Advances

Liver X receptors regulate hepatic F4/80+CD11b+ Kupffer cells/macrophages and innate immune responses in mice

(2018) Kaori Endo-Umeda et al.   Scientific Reports

Fine-tuning the pH response of polymersomes for mimicking and controlling the cell membrane functionality

(2017) Hannes Gumz et al.   Polymer Chemistry

Permeable Protein-Loaded Polymersome Cascade Nanoreactors by Polymerization-Induced Self-Assembly

(2017) Lewis D. Blackman et al.   ACS Macro Letters

Coil-like Enzymatic Biohybrid Structures Fabricated by Rational Design: Controlling Size and Enzyme Activity over Sequential Nanoparticle Bioconjugation and Filtration Steps

(2016) Franka Ennen et al.   ACS Applied Materials & Interfaces

Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells

(2016) T. Liu et al.   BIOSCIENCE REPORTS

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Engineering Intracellular Delivery Nanocarriers and Nanoreactors from Oxidation-Responsive Polymersomes via Synchronized Bilayer Cross-Linking and Permeabilizing Inside Live Cells

(2016) Zhengyu Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical Advancements in the Targeted Therapies against Liver Fibrosis

(2016) Ruchi Bansal et al.   MEDIATORS OF INFLAMMATION

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

(2016) Chong-Yang Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Stimuli-responsive polymersomes for cancer therapy

(2016) Thavasyappan Thambi et al.   Biomaterials Science

Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair

(2016) Christopher R. Fellows et al.   Frontiers in Genetics

Reversibly Switching Bilayer Permeability and Release Modules of Photochromic Polymersomes Stabilized by Cooperative Noncovalent Interactions

(2015) Xiaorui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The carbon tetrachloride model in mice

(2015) D Scholten et al.   LABORATORY ANIMALS

From 1D Rods to 3D Networks: A Biohybrid Topological Diversity Investigated by Asymmetrical Flow Field-Flow Fractionation

(2015) Susanne Boye et al.   MACROMOLECULES

Matrix metalloproteinases in liver injury, repair and fibrosis

(2015) Sergio Duarte et al.   MATRIX BIOLOGY

Mesenchymal stem cell therapy for liver fibrosis

(2015) Young Woo Eom et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Cross-linked polymersomes as nanoreactors for controlled and stabilized single and cascade enzymatic reactions

(2014) David Gräfe et al.   Nanoscale

Overcoming Concealment Effects of Targeting Moieties in the PEG Corona: Controlled Permeable Polymersomes Decorated with Folate-Antennae for Selective Targeting of Tumor Cells

(2014) Mohamed A. Yassin et al.   Small

Breathing Polymersomes: CO2-Tuning Membrane Permeability for Size-Selective Release, Separation, and Reaction

(2013) Qiang Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interstitial Collagen Catabolism

(2013) Gregg B. Fields   JOURNAL OF BIOLOGICAL CHEMISTRY

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Synthetic Bio-nanoreactor: Mechanical and Chemical Control of Polymersome Membrane Permeability

(2012) Jens Gaitzsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular Interactions with Photo-Cross-Linked and pH-Sensitive Polymersomes: Biocompatibility and Uptake Studies

(2012) Jens Gaitzsch et al.   BIOMACROMOLECULES

The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease

(2008) Young-Suk Lim et al.   Clinics in Liver Disease

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Stimuli-Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery

(2008) Ozana Onaca et al.   MACROMOLECULAR BIOSCIENCE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS