Review
Microbiology
Frederic C. Daoud, Maider Coppry, Nicholas Moore, Anne-Marie Rogues
Summary: RCTs show a lower incidence rate of SSIs with triclosan sutures compared with non-triclosan sutures, but no significant difference in microbial diversity of culture-confirmed SSIs was found. The pooled RR of ccSSIs was significant, but the statistical power was low for testing the association between TS antimicrobial activity and reduced SSIs.
Article
Pharmacology & Pharmacy
Sunitha Sampathi, Pankaj Kumar Tiriya, Sujatha Dodoala, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Summary: This study developed ciprofloxacin hydrochloride-loaded gold nanoparticles and coated them onto sterile surgical sutures using an adsorption technique followed by ionotropic crosslinking. The drug-coupled nanoparticle-laden sutures showed enhanced antibacterial properties and prolonged drug release, indicating their potential as a clinical option for preventing surgical site infections.
Review
Nursing
Junru Gao, Yunyun Wang, Jingyu Song, Ze Li, Jianan Ren, Peige Wang
Summary: Negative pressure wound therapy significantly improves wound healing rate, healing time, healing area, hospital stay, and adverse events for surgical site infection patients. However, it is also associated with increased medical costs. Further high-quality randomized controlled trials are needed to optimize the application of negative pressure wound therapy.
JOURNAL OF ADVANCED NURSING
(2021)
Review
Infectious Diseases
Adesoji O. Ademuyiwa, Adewale O. Adisa, Simon Bach, Aneel Bhangu, James Glasbey, Bryar Kadir, Sivesh K. Kamarajah, Elizabeth Li, Rachel Lillywhite, Harvinder Mann, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Omar Omar, Joana Simoes, Donna Smith, Thomas Pinkney, Richard Wilkin, Ewen Harrison, Neil Smart, Elliott H. Taylor, Dhruva Ghosh, Parvez D. Haque, J. C. Allen Ingabire, Faustin Ntirenganya, Lawani Ismail, Janet Martin, Antonio Ramos de la Medina, Peter Pockney, Stephen Tabiri
Summary: This study found no benefit from either alcoholic chlorhexidine skin preparation or triclosan-coated sutures, both of which are more expensive than other readily available alternatives. Therefore, global and national guidance should be reconsidered to remove recommendations for their routine use.
LANCET INFECTIOUS DISEASES
(2022)
Review
Anesthesiology
Alexander J. Fowler, Priyanthi Dias, Sara Hui, Richard Cashmore, Ryan Laloo, Adil N. Ahmad, Michael A. Gillies, Yize I. Wan, Rupert M. Pearse, Tom E. F. Abbott
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness of antimicrobial prophylaxis in preventing surgical site infections. The results suggest that more liberal use of antimicrobial prophylaxis is associated with a small reduction in the risk of surgical site infection, although the harms of antimicrobial treatment are poorly reported. Further research is urgently needed to assess the risks of antimicrobial prophylaxis and inform current practices.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Review
Pharmacology & Pharmacy
R. A. H. W. Chua, S. K. Lim, C. F. Chee, S. P. Chin, L. V. Kiew, K. S. Sim, S. T. Tay
Summary: Sutures are vital in wound healing and surgical interventions, but can also lead to severe surgical site infections. The efficacy of traditional antimicrobial sutures may be compromised by resistant bacterial strains, highlighting the need for alternative approaches to their development.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Surgery
Brigid M. Gillespie, Emma Harbeck, Megan Rattray, Rhea Liang, Rachel Walker, Sharon Latimer, Lukman Thalib, Annette Erichsen Andersson, Bronwyn Griffin, Robert Ware, Wendy Chaboyer
Summary: The worldwide cumulative incidence of SSI in adult general surgical patients is 11%. Factors such as anatomical location, surgical approach, and priority influence SSI rates. Duration of surgery is significantly associated with SSI occurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Review
Medicine, General & Internal
Trisha N. Peel, Eliza Watson, Sue J. Lee
Summary: The use of chlorhexidine-alcohol for surgical site skin preparation was found to be more effective in reducing the risk of surgical site infections compared to iodophor-alcohol. However, the efficacy of chlorhexidine-alcohol may vary depending on the type of surgical procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
M. Farid Mojtahedi, M. Sepidarkish, M. Almukhtar, Y. Eslami, F. Mohammadianamiri, K. Behzad Moghadam, S. Rouholamin, M. Razavi, M. Jafari Tadi, A. Fazlollahpour-Naghibi, Z. Rostami, A. Rostami, M. Rezaeinejad
Summary: This systematic review and meta-analysis aimed to estimate the global and regional incidence of post-caesarean section surgical site infections (SSIs) and associated factors. The study found that the global incidence of post-CS SSIs was 5.63%, with the highest incidence rate in Africa (11.91%) and the lowest in North America (3.87%). Countries with lower income and human development index levels had significantly higher incidence rates. The incidence of post-CS SSIs has been increasing over time, particularly during the COVID-19 pandemic (2019-2023).
JOURNAL OF HOSPITAL INFECTION
(2023)
Review
Biotechnology & Applied Microbiology
R. B. Juncker, B. A. Lazazzera, F. Billi
Summary: Surgical site infections caused by Staphylococcus aureus are a major concern in joint arthroplasty, with antibiotic-resistant strains and biofilm formation making treatment increasingly challenging. Functionalized nanoparticles are proposed as a promising solution due to their strong antimicrobial properties. Research indicates that nanoparticles, particularly those with iron-oxide components or acidic capping agents, show efficacy against S. aureus infections in vivo and in vitro, especially when combined with magnetic field exposure and irradiation.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Review
Oncology
Stefan Morarasu, Cillian Clancy, Nicolae Ghetu, Ana Maria Musina, Natalia Velenciuc, Stefan Iacob, Tudor Frunza, Cristian Ene Roata, Sorinel Lunca, Gabriel-Mihail Dimofte
Summary: Quilting sutures (QS) are an intraoperative technique that significantly decrease seroma formation, volume of postoperative drainage, duration of drainage, and length of hospital stay in breast cancer surgeries. The technique does not have a significant impact on surgical outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Clinical Neurology
Millaray Freire-Archer, Mohamed Sarraj, Alex Koziarz, Patrick Thornley, Fawaz Alshaalan, Haitham Alnemari, Edward Kachur, Mohit Bhandari, Colby Oitment
Summary: This study aimed to determine the incidence rate of deep surgical site infection (SSI) in instrumented spinal fusions and compare available evidence for its management. The results showed that deep SSI is a common complication of spinal surgery, leading to poorer outcomes and higher healthcare costs. Standardized treatment protocols and further research are needed to provide better evidence on deep SSI incidence and management.
Review
Sport Sciences
Di Zhao, Gui-Hong Liang, Jian-Ke Pan, Ling-Feng Zeng, Ming-Hui Luo, He-Tao Huang, Yan-Hong Han, Fang-Zheng Lin, Nan-Jun Xu, Wei-Yi Yang, Jun Liu
Summary: This study evaluated the risk factors for surgical site infections after anterior cruciate ligament reconstruction (ACLR). A systematic review and meta-analysis identified male sex, obesity, tobacco use, diabetes mellitus, steroid use history, previous knee surgery history, professional athletes, revision surgery, hamstring autografts, concomitant lateral extra-articular tenodesis, and a long operation time as factors that increase the risk of surgical site infections after ACLR.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Joselin Valeska Martinez-Sobalvarro, Antonio Alves Pereira Junior, Lucas Borges Pereira, Andre Oliveira Baldoni, Carla Speroni Ceron, Tiago Marques dos Reis
Summary: AMS, including audit, feedback, education, implementation of a protocol, and computer-assisted decision support, have shown effectiveness in promoting adherence to surgical antibiotic prophylaxis protocols, reducing surgical site infection rate, and providing positive economic impacts. However, more randomized clinical trials are needed to improve the evidence level for decision-making.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Review
Dermatology
Dunyao Bai, Fan Zhou, Liuting Wu
Summary: Surgical site infections (SSIs) have a significant impact on patient health and healthcare costs. This meta-analysis examines the effectiveness of antiseptics, chlorhexidine and povidone-iodine, in reducing SSIs and concludes that chlorhexidine is more effective than povidone-iodine.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jie Wu, Qinjie Liu, Xufei Zhang, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: The study reveals that STING plays a critical role in intestinal I/R injury, is closely associated with lipid peroxidation, and its activation is linked to prevention and treatment of damage caused by I/R injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
E. Tartari, S. Tomczyk, D. Pires, B. Zayed, A. P. Coutinho Rehse, P. Kariyo, V Stempliuk, W. Zingg, D. Pittet, B. Allegranzi
Summary: Most countries have IPC programmes and guidelines, but many lack adequate investment in resources and face challenges in implementation and monitoring, especially in low-income countries. Leadership support is crucial to achieving the implementation of core components in all countries.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Engineering, Biomedical
Jinjian Huang, Yungang Jiang, Ye Liu, Yanhan Ren, Ziyan Xu, Zongan Li, Yun Zhao, Xiuwen Wu, Jianan Ren
Summary: This study demonstrates a novel strategy for generating an adhesive by mimicking marine animals and shows that the Da-g-Xan adhesive can significantly improve protective effects on colonic anastomosis in a rat model. The structure of the Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds to allow quick release of dopamine-conjugated xanthan gum, which can regulate inflammatory status and induce type 2 macrophage polarization. The adhesive creates an appropriate microenvironment for tissue healing by promoting chemokine and growth factor secretion from M2 macrophages, enhancing fibroblast migration and proliferation, collagen synthesis, and epithelial vascularization.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Yuan Li, Zhiming Wang, Xiuwen Wu, Gefei Wang, Guosheng Gu, Huajian Ren, Zhiwu Hong, Jianan Ren
Summary: This study comprehensively evaluated the genome-wide DNA methylation changes in intestinal mucosa tissue of adult patients with Crohn's disease. Abnormal DNA methylation sites were identified and correlated with genes related to apoptosis, IL-8 production, and inflammatory pathways. The degree of abnormal methylation of MUC1 was negatively correlated with the disease activity of Crohn's disease, suggesting a potential role in disease progression.
SCIENTIFIC REPORTS
(2021)
Letter
Critical Care Medicine
Sicheng Li, Xiuwen Wu, Jianan Ren
CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ye Liu, Jinjian Huang, Ziyan Xu, Sicheng Li, Yungang Jiang, Gui Wen Qu, Zongan Li, Yun Zhao, Xiuwen Wu, Jianan Ren
Summary: Polyacrylamide/gelatin/silver nanoparticle (PAAm-GelatinAgNPs) ink was designed to improve gelatin-based hydrogels by enhancing their mechanical properties and providing antibacterial capabilities. The ink's shear thinning property enabled the printing of complex 3D scaffolds for potential applications in customized therapy for antimicrobial and anti-UV damage to tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Immunology
Wenbin Gong, Peizhao Liu, Tao Zheng, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: Syk, a cytoplasmic non-receptor protein tyrosine kinase, plays crucial roles in signal transduction in various cells, especially in gut diseases. Inhibitors targeting Syk show great potential for the treatment of gut diseases.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Guopu Chen, Yunru Yu, Xiao Fu, Gefei Wang, Zhiming Wang, Xiuwen Wu, Jianan Ren, Yuanjin Zhao
Summary: Metal organic frameworks (MOFs) are proposed as attractive materials for their adjustable structures and physicochemical properties, with a focus on developing functional materials with catalytic capabilities for biomedical values. Biocompatible manganese metal organic framework (Mn-MOF)-based catalase mimetics with microfluidic microcapsule encapsulation were presented for intravital inflammatory bowel disease (IBD) treatment. These Mn-MOF-encapsulated microcapsules showed high performance in treating spontaneous IBD in interleukin-10-deficient mice by relieving oxidative stress and reducing inflammation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Cell Biology
Qinjie Liu, Jie Wu, Xufei Zhang, Xuanheng Li, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: The STING pathway and its induction of autophagy play a crucial role in immune defense response against pathogenic DNA, but excessive activation of STING can exacerbate organ damage. Increased circulating mtDNA levels and STING activation in sALI patients contribute to lung injury by triggering an inflammatory response and disrupting autophagy. STING activation interferes with lysosomal acidification in an IFN-dependent manner, worsening sepsis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Fan Zhao, Tao Zheng, Wenbin Gong, Jie Wu, Haohao Xie, Weijie Li, Rui Zhang, Peizhao Liu, Juanhan Liu, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: Exosomal dsDNA was found to promote intestinal inflammation via activating the STING pathway in macrophages, and STING deficiency significantly ameliorated colitis. The inhibitor GW4869 showed potential therapeutic effects by inhibiting EVs release in colitis.
CELL DEATH & DISEASE
(2021)
Article
Materials Science, Multidisciplinary
Canwen Chen, Yuetong Wang, Dagan Zhang, Xiuwen Wu, Yun Zhao, Luoran Shang, Jianan Ren, Yuanjin Zhao
Summary: This study introduced a multicompartment polysaccharide core-shell microparticle system for enhancing wound healing, exhibiting excellent antibacterial properties and angiogenesis effects.
APPLIED MATERIALS TODAY
(2021)
Review
Immunology
Yangguang Li, Wenbin Gong, Weizhen Li, Peizhao Liu, Juanhan Liu, Haiyang Jiang, Tao Zheng, Jie Wu, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: This article reviews the activation factors of the IRG1-Itaconate axis and its role in regulating the inflammatory pathway in macrophages. It also summarizes the relationship between the axis and the metabolism of macrophages. Furthermore, it highlights the connections between the IRG1-Itaconate axis and inflammatory diseases.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Cell Biology
Jie Wu, Qinjie Liu, Xufei Zhang, Miaomiao Tan, Xuanheng Li, Peizhao Liu, Lei Wu, Fan Jiao, Zhaoyu Lin, Xiuwen Wu, Xin Wang, Yun Zhao, Jianan Ren
Summary: The mechanism by which STING causes lethal sepsis through inducing macrophage ferroptosis in an interferon-independent manner is explored. The interaction between STING and NCOA4 is found to be critical in this process. The selective 20-HETE synthase inhibitor, HET0016, is shown to reduce STING-induced ferroptosis and mortality in septic mice. These findings provide insights into sepsis and potential therapeutic targets.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Wenbin Gong, Kun Guo, Tao Zheng, Haohao Xie, Weijie Li, Mengxuan Li, Zhiwu Hong, Huajian Ren, Guosheng Gu, Gefei Wang, Xiuwen Wu, Jianan Ren
Summary: The JINLING score was found to be significantly correlated with FCP, CRP, and hemoglobin. In the validation cohort, patients with high inflammation grade (JINLING >= 4) had higher GHAS, CRP, and FCP than low inflammation grade patients. High JINLING score was associated with an increased risk of treatment failure.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Chemistry, Physical
Jinjian Huang, Ye Liu, Xiang Chi, Yungang Jiang, Ziyan Xu, Guiwen Qu, Yun Zhao, Zongan Li, Canwen Chen, Guopu Chen, Xiuwen Wu, Jianan Ren
Summary: This study developed an electronic skin with antibacterial, color-variable, UV-sensitive, shape-adaptive, and immunoregulatory functions, which can simulate the comprehensive functions of real skin. By combining single- and dual-network hydrogel structures with chemical reactions, it achieved the perception of UV and human motions.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)