Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance

Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3

(2019) Ashley E. Landuyt et al.   JOURNAL OF IMMUNOLOGY

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells

(2018) Kathleen Yates et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

Engineering a designer immunotherapy

(2018) Crystal L. Mackall   SCIENCE

Evaluation of the impact of conventional immunosuppressant on the establishment of murine transplantation tolerance - an experimental study

(2018) Haruki Katsumata et al.   TRANSPLANT INTERNATIONAL

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of theIl2ragene locus

(2017) Peng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

(2016) Cameron McDonald-Hyman et al.   BLOOD

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

IL-2 / α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment

(2016) Benedikt Mahr et al.   PLoS One

Clonal Deletion Established via Invariant NKT Cell Activation and Costimulatory Blockade RequiresIn VivoExpansion of Regulatory T Cells

(2015) T. Hirai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain’t That Peculiar (with Apologies to Marvin Gaye)

(2015) David H. Raulet   JOURNAL OF IMMUNOLOGY

Depletion of Foxp3+T Cells Abrogates Tolerance of Skin and Heart Allografts in Murine Mixed Chimeras Without the Loss of Mixed Chimerism

(2014) K. Shinoda et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment

(2014) A. M. S. Muller et al.   BLOOD

Transplantation Survival Is Maintained by Granzyme B+ Regulatory Cells and Adaptive Regulatory T Cells

(2014) D. C. Gondek et al.   JOURNAL OF IMMUNOLOGY

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

(2014) Debalina Sarkar et al.   Molecular Therapy-Methods & Clinical Development

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Limitations of IL-2 and Rapamycin in Immunotherapy of Type 1 Diabetes

(2013) Audrey Baeyens et al.   DIABETES

T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model

(2013) Nina Pilat et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Tolerance and Withdrawal of Immunosuppressive Drugs in Patients Given Kidney and Hematopoietic Cell Transplants

(2012) J. D. Scandling et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T-cell therapy for transplantation

(2012) Qizhi Tang et al.   Current Opinion in Organ Transplantation

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

ICOS-Dependent Homeostasis and Function of Foxp3+ Regulatory T Cells in Islets of Nonobese Diabetic Mice

(2012) M. Kornete et al.   JOURNAL OF IMMUNOLOGY

NK Cells and Immune "Memory"

(2011) J. C. Sun et al.   JOURNAL OF IMMUNOLOGY

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Efficacy of Polyclonal Tregs Does Not Require Rapamycin in a Low-Dose Irradiation Bone Marrow Transplantation Model

(2011) Nina Pilat et al.   TRANSPLANTATION

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

In Situ Activation and Expansion of Host Tregs: A New Approach to Enhance Donor Chimerism and Stable Engraftment in Major Histocompatibility Complex-Matched Allogeneic Hematopoietic Cell Transplantation

(2009) Alwi Shatry et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression

(2008) Tatsuo Kawai et al.   NEW ENGLAND JOURNAL OF MEDICINE