Article
Endocrinology & Metabolism
Upneet K. Sokhi, Yunwei Xia, Branden Sosa, Kathleen Turajane, Sita N. Nishtala, Tania Pannellini, Mathias P. Bostrom, Alberto Carli, Xu Yang, Lionel B. Ivashkiv
Summary: This study characterized the immune response in orthopedic periprosthetic joint infection (PJI) using histology, flow cytometry, and gene expression analysis. The results showed that persistent S. aureus infection leads to robust activation of both innate and adaptive immunity, as well as ongoing inflammation and lymph node and bone marrow reactions. However, there are feedback mechanisms that suppress immune cell activation and inhibit T-cell proliferation and tissue infiltration. These findings provide insights into the immune response to persistent S. aureus PJI and suggest potential targets for immunotherapeutic strategies.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Microbiology
Gabriele Meroni, Alexios Tsikopoulos, Konstantinos Tsikopoulos, Francesca Allemanno, Piera Anna Martino, Joel Fernando Soares Filipe
Summary: Osteomyelitis is a bone infection that can spread through hematogenous, contiguous, or direct inoculation routes. Animal models can be used to study osteomyelitis, and different species are chosen for research. The clinical manifestation of hematogenous osteomyelitis varies due to multiple factors, but these variables can be controlled and tested through animal models.
Review
Engineering, Biomedical
Omer Suljevic, Stefan F. Fischerauer, Annelie M. Weinberg, Nicole G. Sommer
Summary: Magnesium-based implants have valuable properties for orthopedic surgery, but their interactions with the immune system are still not fully understood. A systematic review of in vivo studies revealed that Mg-based implants generally trigger mild to moderate immune responses, but the underlying mechanisms require further investigation.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Yun-Qi Wu, Zheng Liu, Zhenchao Xu, Yilu Zhang, Hongru Ye, Xiyang Wang
Summary: Recent advances in osteoimmunology have highlighted the important role of immune cells in bone formation, particularly in response to 3D-printed scaffolds. The study found that macrophages exhibited M2 phenotype characteristics and generated an anti-inflammatory microenvironment when interacting with the scaffolds. Specifically, the hexagonal pore scaffold showed a greater enhancement of osteoblastic differentiation compared to the triangular pore scaffold.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Materials Science, Biomaterials
A. Costa, S. Gemini-Piperni, A. C. Alves, N. A. Costa, N. R. Checca, P. E. Leite, L. A. Rocha, A. M. P. Pinto, F. Toptan, A. L. Rossi, A. R. Ribeiro
Summary: This study evaluated the effect of varying amounts of Sr in a TiO2 porous layer, with higher Sr content increasing Ca/P ratio and promoting the formation of SrTiO3 compound. Lower Sr concentrations did not affect initial cell adhesion or viability, but rather enhanced mineralization. A Ca-P-TiO2 porous layer with less Sr concentration seems to be an ideal candidate for bone implants.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Nadia Kartikasari, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Xindie He, Yuya Kamano, Hiroshi Egusa
Summary: This study shows that titanium nanosurfaces with anisotropically patterned nanospikes can regulate macrophage polarization to inhibit osteoclast differentiation of osteoclast precursors, indicating that nanotopographic cues play a key role in this process rather than other physicochemical properties.
ACTA BIOMATERIALIA
(2022)
Article
Endocrinology & Metabolism
Helena Kames Kjeldgaard, Haakon E. Meyer, Martin O'Flaherty, Ellen M. Apalset, Cecilie Dahl, Nina Emaus, Anne Marie Fenstad, Ove Furnes, Jan-Erik Gjertsen, Mari Hoff, Berit Schei, Anne Johanne Sogaard, Grethe S. Tell, Kristin Holvik
Summary: The study found that hip fracture rates in Norway are declining, while rates of total hip replacements have been increasing. The increasing prevalence of hip prostheses significantly contributed to the observed declining trends.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Maria Menini, Francesca Delucchi, Domenico Baldi, Francesco Pera, Francesco Bagnasco, Paolo Pesce
Summary: The study evaluated the inflammatory response induced by five different dental implants in macrophages, with results showing that all samples had optimal outcomes without significant inflammatory stimulus. Although the 3iT3 implant exhibited a slight pro-inflammatory effect compared to other samples, no implant triggered a significant inflammatory response in macrophages.
APPLIED SCIENCES-BASEL
(2021)
Article
Infectious Diseases
Johanne Gade Lilleore, Andrea Rene Jorgensen, Martin Bruun Knudsen, Pelle Hanberg, Kristina Obrink-Hansen, Sara Kousgaard Tostesen, Kjeld Soballe, Maiken Stilling, Mats Bue
Summary: This study assessed the steady-state piperacillin concentrations near an orthopedic implant to protect against infection. Results showed similar time above the minimal inhibitory concentration (fT>MIC) for the low target (8 μg/mL) across all investigated compartments. However, for the high target (16 μg/mL), fT>MIC was shorter inside the cannulated screw compared to cancellous bone next to the screw and plasma, but similar between the two cancellous bone compartments. Alternative dosing regimens, such as continuous infusion, may be considered to achieve more aggressive piperacillin fT>MIC targets in relation to the implant.
Review
Orthopedics
Meng Meng, Jinzuo Wang, Huagui Huang, Xin Liu, Jing Zhang, Zhonghai Li
Summary: This paper systematically reviews the literature on 3D printing orthopedic metal implants over the past decade. It introduces the advantages and applications of 3D printing technology and discusses its potential possibilities in orthopedic surgery. The paper emphasizes the personalized nature of 3D printing technology and its advantages in improving patient recovery.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Chemistry, Applied
Fenghua Tao, Sijia Ma, Hai Tao, Lin Jin, Yue Luo, Jian Zheng, Wei Xiang, Hongbing Deng
Summary: Chitosan, a cationic polysaccharide extracted from chitin, has gained attention in bacterial inhibition and drug delivery. Local antibiotic delivery after surgical debridement using chitosan-based biomaterials is effective in overcoming antibiotic resistance and reducing systemic toxicity in the treatment of osteomyelitis. This review highlights recent advances and future perspectives in utilizing chitosan-based drug delivery systems for osteomyelitis treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Immunology
Jenna R. Petronglo, Nicole E. Putnam, Caleb A. Ford, Virginia Cruz-Victorio, Jacob M. Curry, Casey E. Butrico, Laura E. Fulbright, Joshua R. Johnson, Sun H. Peck, Sana R. Fatah, James E. Cassat
Summary: Staphylococcus aureus is the major causative agent of bacterial osteomyelitis. TLR2 and TLR9 have context-dependent roles in altering bone homeostasis during osteomyelitis, but the underlying mechanisms are still unclear.
INFECTION AND IMMUNITY
(2022)
Article
Veterinary Sciences
Jessica J. Smith, Po-Yen Chou, Barbro Filliquist, Denis J. Marcellin-Little, Amy S. Kapatkin
Summary: This study reported the outcome of locally administered antibiotic-impregnated poloxamer 407 (P407) hydrogel in dogs with orthopedic surgical site infections (SSIs), and identified risk factors for treatment failure. The findings showed that the number of surgeries performed and the presence of multidrug or methicillin resistance were associated with increased risk of treatment failure.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
C. Kreis, F. K. Aschenbrenner, D. Guenther, N. Tholema-Hans, J. Koeppe, S. B. Rosslenbroich, M. J. Raschke, T. Fuchs
Summary: This study aims to develop a standardized and reproducible in-vivo model of osteomyelitis to improve treatment options for implant-associated infections. The study analyzes the effects of post-infectious implant exchange, systemic versus local antibiotic treatment, and the use of a local drug-delivery system. The results demonstrate the clear advantage of combined local and systemic antibiotic treatment. The findings from this study are important for further investigations into treatment options and influencing factors for osteomyelitis and implant-associated infections.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Maria-Bernadette Madel, Julia Halper, Lidia Ibanez, Lozano Claire, Matthieu Rouleau, Antoine Boutin, Adrien Mahler, Rodolphe Pontier-Bres, Thomas Ciucci, Majlinda Topi, Christophe Hue, Jerome Amiaud, Salvador Iborra, David Sancho, Dominique Heymann, Henri-Jean Garchon, Dorota Czerucka, Florence Apparailly, Isabelle Duroux-Richard, Abdelilah Wakkach, Claudine Blin-Wakkach
Summary: This study explores the specific traits of inflammatory and steady-state osteoclasts using transcriptomic profiling, differentiation assays, and in vivo analysis in mice. The authors identify and validate pattern-recognition receptors (PRR) Tlr2, Dectin-1, and Mincle as major regulators of inflammatory osteoclasts. They demonstrate that the administration of the yeast probiotic Saccharomyces boulardii CNCM I-745 (Sb) reduces bone loss in ovariectomized mice by regulating the inflammatory environment and inhibiting inflammatory osteoclastogenesis. The study also shows that Sb derivatives and agonists of Tlr2, Dectin-1, and Mincle specifically inhibit the differentiation of inflammatory osteoclasts in vitro. These findings have important implications for the development of therapeutic strategies for inflammatory bone loss.
Article
Endocrinology & Metabolism
Ghada A. Otaify, Michael P. Whyte, Gary S. Gottesman, William H. McAlister, J. Eric Gordon, Abby Hollander, Marisa V. Andrews, Samir K. El-Mofty, Wei-Shen Chen, Deborah V. Veis, Marina Stolina, Albert S. Woo, Panagiotis Katsonis, Olivier Lichtarge, Fan Zhang, Marwan Shinawi
Article
Oncology
Wendy Yen Yun Chou, Deborah J. Veis, Rebecca Aft
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Endocrinology & Metabolism
Michael P. Whyte, Emilina Lim, William H. McAlister, Gary S. Gottesman, Lien Trinh, Deborah J. Veis, Vinieth N. Bijanki, Matthew G. Boden, Angela Nenninger, Steven Mumm, David Buchbinder
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Morten Frost, Michaela Tencerova, Christina M. Andreasen, Thomas L. Andersen, Charlotte Ejersted, Dea Svaneby, Weimin Qui, Moustapha Kassem, Allandad Zarei, William H. McAlister, Deborah J. Veis, Michael P. Whyte, Anja L. Frederiksen
Article
Immunology
Sahil Mahajan, Corinne E. Decker, Zhengfeng Yang, Deborah Veis, Elizabeth D. Mellins, Roberta Faccio
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Microbiology
Alissa R. Young, Marissa C. Locke, Lindsey E. Cook, Bradley E. Hiller, Rong Zhang, Matthew L. Hedberg, Kristen J. Monte, Deborah J. Veis, Michael S. Diamond, Deborah J. Lenschow
Article
Microbiology
Jennifer L. Krauss, Philip M. Roper, Anna Ballard, Chien-Cheng Shih, James A. J. Fitzpatrick, James E. Cassat, Pei Ying Ng, Nathan J. Pavlos, Deborah J. Veis
Article
Endocrinology & Metabolism
Anna Cline-Smith, Ariel Axelbaum, Elena Shashkova, Mousumi Chakraborty, Jessie Sanford, Prabhjyot Panesar, Macey Peterson, Linda Cox, Angel Baldan, Deborah Veis, Rajeev Aurora
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L. Kostecki, Joseph B. Monahan, Deborah J. Veis, Yousef Abu-Amer, Daniel C. Link, Gabriel Mbalaviele
Review
Cell Biology
Philip M. Roper, Christine Shao, Deborah J. Veis
Article
Multidisciplinary Sciences
Bradley T. Estes, Masataka Enomoto, Franklin T. Moutos, Megan A. Carson, Jeffrey M. Toth, Peter Eggert, Jonathan Stallrich, Vincent P. Willard, Deborah J. Veis, Dianne Little, Farshid Guilak, B. Duncan X. Lascelles
Summary: The study demonstrated that a tissue-engineered bicomponent implant, combining new technologies and components, was able to restore hip function in a canine model of hip osteoarthritis. The implant showed potential as a therapy for moderate hip osteoarthritis, providing clinically relevant evidence of its efficacy.
Proceedings Paper
Microscopy
Terence T. W. Wong, Ruiying Zhang, Pengfei Hai, Rebecca L. Aft, Deborah V. Novack, Lihong V. Wang
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2018
(2018)
Article
Medicine, Research & Experimental
Ashraf Ul Kabir, Tae-Jin Lee, Hua Pan, Jeffrey C. Berry, Karen Krchma, Jun Wu, Fang Liu, Hee-Kyoung Kang, Kristina Hinman, Lihua Yang, Samantha Hamilton, Qingyu Zhou, Deborah J. Veis, Robert P. Mecham, Samuel A. Wickline, Mark J. Miller, Kyunghee Choi
Article
Medicine, Research & Experimental
Sarah Evans, Huei-Ping Tzeng, Deborah J. Veis, Scot Matkovich, Carla Weinheimer, Attila Kovacs, Philip M. Barger, Douglas L. Mann