Evolutionary Constraint on Visual and Nonvisual Mammalian Opsins

A Novel Approach to Investigate the Effect of Tree Reconstruction Artifacts in Single-Gene Analysis Clarifies Opsin Evolution in Nonbilaterian Metazoans

(2020) James F Fleming et al.   Genome Biology and Evolution

Rhodopsin and melanopsin coexist in mammalian sperm cells and activate different signaling pathways for thermotaxis

(2020) Debarun Roy et al.   Scientific Reports

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

(2020) Gowri Nayak et al.   Cell Reports

Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes

(2020) Mari Sato et al.   PLOS BIOLOGY

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision

(2020) Rebecca Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation

(2020) Juan C. Valdez-Lopez et al.   PLoS One

Activation of an Endogenous Opsin 3 Light Receptor Mediates Photo-Relaxation of Pre-Contracting Late Gestation Human Uterine Smooth Muscle Ex Vivo

(2020) Peter D. Yim et al.   Reproductive Sciences

Six reference-quality genomes reveal evolution of bat adaptations

(2020) David Jebb et al.   NATURE

A discrete neuronal circuit induces a hibernation-like state in rodents

(2020) Tohru M. Takahashi et al.   NATURE

Neurons that regulate mouse torpor

(2020) Sinisa Hrvatin et al.   NATURE

Shedding new light on the generation of the visual chromophore

(2020) Krzysztof Palczewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opsin 3-Gαs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2

(2020) Amy D Wu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons

(2020) Kevin X. Zhang et al.   NATURE

An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye

(2019) Minh-Thanh T. Nguyen et al.   NATURE CELL BIOLOGY

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells

(2019) Ala Morshedian et al.   NEURON

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor

(2019) Rana N. Ozdeslik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vision using multiple distinct rod opsins in deep-sea fishes

(2019) Zuzana Musilova et al.   SCIENCE

Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits

(2019) Lei Chen et al.   SCIENCE

Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin

(2019) Ethan D. Buhr et al.   CURRENT BIOLOGY

Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

(2019) Jianye Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior

(2019) Michael Tri H. Do   NEURON

Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition

(2018) Sebastian Barreto Ortiz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Proprioceptive Opsin Functions in Drosophila Larval Locomotion

(2018) Damiano Zanini et al.   NEURON

An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor

(2018) Takashi Nagata et al.   Scientific Reports

Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level Genomes for All Living Bat Species

(2018) Emma C. Teeling et al.   Annual Review of Animal Biosciences

Airway smooth muscle photorelaxation via opsin receptor activation

(2018) Peter D. Yim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

The UCSC Genome Browser database: 2019 update

(2018) Maximilian Haeussler et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2019

(2018) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

(2018) Jeffrey R. Moffitt et al.   SCIENCE

Multifactorial processes underlie parallel opsin loss in neotropical bats

(2018) Alexa Sadier et al.   eLife

Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium

(2017) Jeremy D. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times

(2017) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice

(2017) Preethi Somasundaram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rises and falls of opsin genes in 59 ray-finned fish genomes and their implications for environmental adaptation

(2017) Jinn-Jy Lin et al.   Scientific Reports

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure

(2017) James H. Felce et al.   Cell Reports

Warm-Sensitive Neurons that Control Body Temperature

(2016) Chan Lek Tan et al.   CELL

Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis

(2016) Sangho Yu et al.   JOURNAL OF NEUROSCIENCE

RGR variants in different forms of retinal diseases: The undetermined role of truncation mutations

(2016) Jiali Li et al.   Molecular Medicine Reports

Dimerization of visual pigments in vivo

(2016) Tao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants

(2016) Birgit Ploier et al.   Nature Communications

Non-image Forming Light Detection by Melanopsin, Rhodopsin, and Long-Middlewave (L/W) Cone Opsin in the Subterranean Blind Mole Rat, Spalax Ehrenbergi: Immunohistochemical Characterization, Distribution, and Connectivity

(2016) Gema Esquiva et al.   Frontiers in Neuroanatomy

A Switch in Thermal Preference in Drosophila Larvae Depends on Multiple Rhodopsins

(2016) Takaaki Sokabe et al.   Cell Reports

Absorption Characteristics of Vertebrate Non-Visual Opsin, Opn3

(2016) Tomohiro Sugihara et al.   PLoS One

Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum

(2016) Mutsuko Kato et al.   PLoS One

High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes

(2015) Myung-Sook Choi et al.   BRITISH JOURNAL OF NUTRITION

Isoforms of Melanopsin Mediate Different Behavioral Responses to Light

(2015) Aarti Jagannath et al.   CURRENT BIOLOGY

Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface

(2015) Beata Jastrzebska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanopsin Tristability for Sustained and Broadband Phototransduction

(2015) Alan Joseph Emanuel et al.   NEURON

Nonvisual Opsins and the Regulation of Peripheral Clocks by Light and Hormones

(2015) Maristela O. Poletini et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea

(2015) Ethan D. Buhr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of opsins in mammalian sperm thermotaxis

(2015) Serafín Pérez-Cerezales et al.   Scientific Reports

Diversity of Active States in TMT Opsins

(2015) Kazumi Sakai et al.   PLoS One

Identification of Critical Phosphorylation Sites on the Carboxy Tail of Melanopsin

(2014) Joseph R. Blasic et al.   BIOCHEMISTRY

Evolution of Mammalian Opn5 as a Specialized UV-absorbing Pigment by a Single Amino Acid Mutation

(2014) Takahiro Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eyes underground: Regression of visual protein networks in subterranean mammals

(2014) Christopher A. Emerling et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

Opsin Expression in Human Epidermal Skin

(2014) Kirk Haltaufderhyde et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Circadian Regulation of Lipid Mobilization in White Adipose Tissues

(2013) A. Shostak et al.   DIABETES

A direct and melanopsin-dependent fetal light response regulates mouse eye development

(2013) Sujata Rao et al.   NATURE

The nocturnal bottleneck and the evolution of activity patterns in mammals

(2013) M. P. Gerkema et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rod Monochromacy and the Coevolution of Cetacean Retinal Opsins

(2013) Robert W. Meredith et al.   PLoS Genetics

Drosophila Auditory Organ Genes and Genetic Hearing Defects

(2012) Pingkalai R. Senthilan et al.   CELL

Melanopsin Is Highly Resistant to Light and Chemical Bleachingin Vivo

(2012) Timothy J. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity in mice with adipocyte-specific deletion of clock component Arntl

(2012) Georgios K Paschos et al.   NATURE MEDICINE

T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks

(2012) A. Boc et al.   NUCLEIC ACIDS RESEARCH

Differential Expression of Melanopsin Isoforms Opn4L and Opn4S during Postnatal Development of the Mouse Retina

(2012) Steven Hughes et al.   PLoS One

Phosphorylation of Mouse Melanopsin by Protein Kinase A

(2012) Joseph R. Blasic et al.   PLoS One

Metazoan opsin evolution reveals a simple route to animal vision

(2012) R. Feuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-dependent phosphorylation of the carboxy tail of mouse melanopsin

(2011) Joseph R. Blasic et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

(2011) Eun Bae Kim et al.   NATURE

UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice

(2011) Daisuke Kojima et al.   PLoS One

Function of Rhodopsin in Temperature Discrimination in Drosophila

(2011) W. L. Shen et al.   SCIENCE

Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions

(2011) Weixin Wang et al.   Scientific Reports

A Blind Circadian Clock in Cavefish Reveals that Opsins Mediate Peripheral Clock Photoreception

(2011) Nicola Cavallari et al.   PLOS BIOLOGY

Light Perception in Two Strictly Subterranean Rodents: Life in the Dark or Blue?

(2010) Ondřej Kott et al.   PLoS One

Melanopsin-dependent light avoidance in neonatal mice

(2010) J. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds

(2010) Y. Nakane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein

(2010) T. Yamashita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetics of normal and defective color vision

(2010) Jay Neitz et al.   VISION RESEARCH

Differential Expression of Two Distinct Functional Isoforms of Melanopsin (Opn4) in the Mammalian Retina

(2009) S. S. Pires et al.   JOURNAL OF NEUROSCIENCE

Database resources of the National Center for Biotechnology Information

(2009) E. W. Sayers et al.   NUCLEIC ACIDS RESEARCH

Evolution of Dim-Light and Color Vision Pigments

(2008) Shozo Yokoyama   Annual Review of Genomics and Human Genetics

Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation

(2008) J. H. White et al.   HUMAN MOLECULAR GENETICS

A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder

(2008) Kathryn A. Roecklein et al.   JOURNAL OF AFFECTIVE DISORDERS

Retinal Pigment Epithelium-Retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of All-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells

(2008) Roxana A. Radu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Role of the “Ionic Lock”—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors

(2008) Reiner Vogel et al.   JOURNAL OF MOLECULAR BIOLOGY

Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision

(2008) Ali D. Güler et al.   NATURE

Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation

(2008) C. M. Altimus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of vertebrate visual pigments

(2008) James K. Bowmaker   VISION RESEARCH

Cone visual pigments of monotremes: Filling the phylogenetic gap

(2008) MATTHEW J. WAKEFIELD et al.   VISUAL NEUROSCIENCE