Article
Oncology
Patrick T. Magahis, Steven B. Maron, Darren Cowzer, Stephanie King, Mark Schattner, Yelena Janjigian, David Faleck, Monika Laszkowska
Summary: This study found an association between H. pylori infection and inferior survival in patients with gastric cancer treated with immune checkpoint inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Jia-Bin Wang, Qing-Zhu Qiu, Qiao-Ling Zheng, Ya-Jun Zhao, Yu Xu, Tao Zhang, Shuan-Hu Wang, Quan Wang, Qin-Wen Jin, Yin-Hua Ye, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Ying-Hong Yang, Chao-Hui Zheng, Chang-Ming Huang
Summary: In this study, a gastric cancer immunophenotypic score (IPS) was constructed based on the tumor microenvironment classification, which can predict the effectiveness of immune checkpoint inhibitor therapy. The IPS provides a practical reference for implementing neoadjuvant ICI therapy for patients with gastric cancer.
Review
Immunology
Paul Oster, Laurie Vaillant, Brynn McMillan, Dominique Velin
Summary: Helicobacter pylori infects the gastric mucosa and can lead to various diseases. It establishes a chronic infection by suppressing the host immune system. Studies have shown that H. pylori infection is associated with a reduced incidence of certain inflammatory diseases, but it may also impact the effectiveness of cancer immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thomas Bartl, Arina Onoprienko, Gerda Hofstetter, Leonhard Muellauer, Nina Poetsch, Thorsten Fuereder, Paul Kofler, Stephan Polterauer, Christoph Grimm
Summary: Pretherapeutic body mass index (BMI) could be a reliable biomarker for identifying gynecologic malignancy patients with PD-L1-positive and/or MMR-deficient tumors who may benefit significantly from checkpoint inhibitor therapy.
Article
Oncology
Hebin Che, Qi Xiong, Jinxia Ma, Shixue Chen, Huan Wu, Hongli Xu, Baicun Hou
Summary: This study reveals that H. pylori infection is associated with the outcome of immunotherapy for advanced gastric cancer patients. Patients who are H. pylori positive have a higher risk of nonclinical response to anti-PD-1 antibody and shorter overall survival and progression-free survival. Further multicenter, large sample, and prospective clinical studies are needed to verify this association.
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xin Jin, Zhaorui Liu, Dongxiao Yang, Kai Yin, Xusheng Chang
Summary: Gastric carcinoma is a common form of solid tumor and is the third leading cause of death worldwide. The lack of obvious symptoms makes it difficult to detect gastric cancer at earlier stages, leading to a poor prognosis. However, recent advances in understanding the microenvironment of cancer have significantly promoted the development of immunotherapy for advanced gastric cancer. Immunotherapy has shown robust efficacy and tolerable toxicity compared to traditional therapies, making it a popular novel strategy for the treatment of advanced gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Yukiya Narita, Kei Muro
Summary: Gastric cancer treatments are rapidly evolving, with immune checkpoint inhibitors targeting PD-1 or PD-L1 showing long-term efficacy in some patients and currently being the first-line therapy. Approved immunotherapies for untreated gastric cancer patients include monotherapy and chemotherapy-immunotherapy combinations. Clinical trials have indicated the importance of PD-L1 expression in regimen selection, although other biomarkers, clinicopathologic factors, and patient preference might also be relevant. Novel biomarkers and therapeutic strategies are currently being assessed, potentially refining the current treatment paradigm. This review describes current treatment regimens for gastric cancer patients and details our approach to selecting first-line immunotherapy regimens.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Kai Liu, Shiman Yuan, Chenyu Wang, Hong Zhu
Summary: Gastric cancer (GC) is a common gastrointestinal malignancy with high mortality. New immunotherapies such as immune checkpoint inhibitors (ICIs) have changed the treatment of GC patients, but only a small number of patients have a durable response to ICI treatment. Understanding the resistance mechanism is critical to improve the treatment and clinical benefit of GC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Yihan Yang, Xu Shu, Chuan Xie
Summary: This paper reviews the impact of H. pylori infection on autophagy and the progression of gastric cancer signaling pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mohammad Ahmadvand, Hamid Asadzadeh Aghdaei, Somayeh Ebrahimi-Barough, Jafar Ai, Mohammad Reza Zali, Javad Verdi, Kaveh Baghaei
Summary: This study demonstrated that a combination therapy of ex vivo activated NK cells and anti-PD-1 treatment resulted in tumor growth inhibition and enhanced immune cell infiltration in a xenograft gastric cancer model. The cytotoxic potential of the treated NK cells against gastric cancer cell lines was evaluated through a series of assays, showing promising anti-tumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)