HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review

Elevated apolipoprotein A1 and HDL cholesterol associated with age-related macular degeneration: two population cohorts

(2021) Liv Tybjærg Nordestgaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease

(2020) Gregory G. Schwartz et al.   DIABETES CARE

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

(2020) Jan Borén et al.   EUROPEAN HEART JOURNAL

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened

(2020) Mustafa Yalcinkaya et al.   JOURNAL OF LIPID RESEARCH

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

(2020) Tom G. Richardson et al.   PLOS MEDICINE

Effect of CETP inhibition with evacetrapib in patients with diabetes mellitus enrolled in the ACCELERATE trial

(2020) Venu Menon et al.   BMJ Open Diabetes Research & Care

High density lipoproteins are a potential therapeutic target for age-related macular degeneration

(2020) Una L. Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

HDL (High-Density Lipoprotein) and ApoA-1 Potentially Modulate Pancreatic α-Cell Glucagon Secretion

(2020) Elettra Mancuso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

(2020) Thomas W. Winkler et al.   BMC Medical Genomics

Novel Insights From Human Studies on the Role of High-Density Lipoprotein in Mortality and Noncardiovascular Disease

(2020) Christian M. Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis

(2020) Mark Trinder et al.   CIRCULATION

Impact of metabolic dysfunction on cognition in humans

(2020) Ida Juul Rasmussen et al.   CURRENT OPINION IN LIPIDOLOGY

The effects of eight serum lipid biomarkers on age-related macular degeneration risk: a Mendelian randomization study

(2020) Xikun Han et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up

(2019) Thomas Svensson et al.   Translational Psychiatry

Rethinking good cholesterol: a clinicians' guide to understanding HDL

(2019) Angie S Xiang et al.   Lancet Diabetes & Endocrinology

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

High HDL cholesterol: A risk factor for diabetic retinopathy? Findings from NO BLIND study

(2019) Ferdinando Carlo Sasso et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

ApoAI-derived peptide increases glucose tolerance and prevents formation of atherosclerosis in mice

(2019) Shelley J. Edmunds et al.   DIABETOLOGIA

Apolipoprotein A-I improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1

(2019) Liming Hou et al.   FASEB JOURNAL

Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort

(2019) Katrine L Rasmussen et al.   EUROPEAN HEART JOURNAL

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

(2019) Sonia Moreno-Grau et al.   Alzheimers & Dementia

2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

(2019) Francesco Cosentino et al.   EUROPEAN HEART JOURNAL

Apolipoprotein A-I primes beta cells to increase glucose stimulated insulin secretion

(2019) Oktawia Nilsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Causal Inference for Genetically Determined Levels of High-Density Lipoprotein Cholesterol and Risk of Infectious Disease

(2019) Mark Trinder et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

(2019) Yu An et al.   Molecular Neurodegeneration

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

(2018) Juho Tynkkynen et al.   Alzheimers & Dementia

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

(2018) Sven J. van der Lee et al.   Alzheimers & Dementia

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

(2018) Eveline Kersten et al.   SURVEY OF OPHTHALMOLOGY

Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial

(2018) Stephen J. Nicholls et al.   JAMA Cardiology

Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

(2018) Johanna M. Colijn et al.   OPHTHALMOLOGY

High-density lipoprotein (HDL) and infections: a versatile culprit

(2017) Thimoteus Speer et al.   EUROPEAN HEART JOURNAL

U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies

(2017) Christian M Madsen et al.   EUROPEAN HEART JOURNAL

Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies

(2017) Christian M. Madsen et al.   EUROPEAN HEART JOURNAL

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization

(2017) Qiao Fan et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis

(2017) Kaarin J. Anstey et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein status in type 2 diabetes mellitus and its complications

(2017) Puhong Zhang et al.   Molecular Medicine Reports

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

(2017) Michael V. Holmes et al.   Nature Reviews Cardiology

Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

(2017) A. Michael Lincoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol–Associated Mechanisms in Etiology of Age-Related Macular Degeneration

(2017) Stephen Burgess et al.   OPHTHALMOLOGY

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer’s disease: the National Finnish population study (FINRISK)

(2016) Juho Tynkkynen et al.   AGE

High Density Lipoprotein Cholesterol and the Risk of All-Cause Mortality among U.S. Veterans

(2016) Benjamin Bowe et al.   Clinical Journal of the American Society of Nephrology

HDLs in crises

(2016) Arnold von Eckardstein et al.   CURRENT OPINION IN LIPIDOLOGY

High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions

(2016) Dennis T. Ko et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

(2016) Paolo Zanoni et al.   SCIENCE

The changing face of diabetes complications

(2016) Edward W Gregg et al.   Lancet Diabetes & Endocrinology

Association of Lipid Fractions With Risks for Coronary Artery Disease and Diabetes

(2016) Jon White et al.   JAMA Cardiology

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

(2015) Liv Tybjærg Nordestgaard et al.   Alzheimers & Dementia

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

(2015) Tove Fall et al.   DIABETES

HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study

(2015) Christiane L. Haase et al.   DIABETES

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

New loci and coding variants confer risk for age-related macular degeneration in East Asians

(2015) Ching-Yu Cheng et al.   Nature Communications

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

(2015) Søren D. Østergaard et al.   PLOS MEDICINE

A Multiancestral Genome-Wide Exome Array Study of Alzheimer Disease, Frontotemporal Dementia, and Progressive Supranuclear Palsy

(2015) Jason A. Chen et al.   JAMA Neurology

Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic β-Cells via a G-Protein-cAMP-PKA-FoxO1–Dependent Mechanism

(2014) Blake J. Cochran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?

(2014) Naishi Li et al.   ATHEROSCLEROSIS

HDL in innate and adaptive immunity

(2014) A. L. Catapano et al.   CARDIOVASCULAR RESEARCH

High-density lipoprotein, beta cells, and diabetes

(2014) A. von Eckardstein et al.   CARDIOVASCULAR RESEARCH

HDL and cognition in neurodegenerative disorders

(2014) David A. Hottman et al.   NEUROBIOLOGY OF DISEASE

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients

(2014) D. Keene et al.   BMJ-British Medical Journal

Highly Penetrant Alleles in Age-Related Macular Degeneration

(2014) A. I. den Hollander et al.   Cold Spring Harbor Perspectives in Medicine

Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

(2014) Petroula Proitsi et al.   PLOS MEDICINE

High-Density Lipoprotein Maintains Skeletal Muscle Function by Modulating Cellular Respiration in Mice

(2013) Maarit Lehti et al.   CIRCULATION

Effects of High-Density Lipoprotein Elevation With Cholesteryl Ester Transfer Protein Inhibition on Insulin Secretion

(2013) Andrew L. Siebel et al.   CIRCULATION RESEARCH

Killing Two Birds With One Stone, Maybe

(2013) Sergio Fazio et al.   CIRCULATION RESEARCH

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Cholesterol Efflux and Atheroprotection

(2012) Robert S. Rosenson et al.   CIRCULATION

ABC Transporter Genes and Risk of Type 2 Diabetes: A study of 40,000 individuals from the general population

(2012) J. Schou et al.   DIABETES CARE

Genetic Inhibition of CETP, Ischemic Vascular Disease and Mortality, and Possible Adverse Effects

(2012) Trine Holm Johannsen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

The emerging role of HDL in glucose metabolism

(2012) Brian G. Drew et al.   Nature Reviews Endocrinology

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome

(2012) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

The oil spill in ageing Bruch membrane

(2011) C. A. Curcio et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Effect of Torcetrapib on Glucose, Insulin, and Hemoglobin A 1c in Subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) Trial

(2011) Philip J. Barter et al.   CIRCULATION

LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals

(2011) Christiane L. Haase et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

(2010) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

Genetically Elevated Apolipoprotein A-I, High-Density Lipoprotein Cholesterol Levels, and Risk of Ischemic Heart Disease

(2010) Christiane L. Haase et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

(2010) B. M. Neale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium

(2009) K G Duncan et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus

(2009) Brian G. Drew et al.   CIRCULATION

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

(2009) Elizabeth Suchi Chen et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes

(2009) A. Gatti et al.   DIABETES CARE

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

(2009) The Emerging Risk Factors Collaboration*   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Apolipoprotein A-I mimetic peptides

(2008) Brian J. Van Lenten et al.   Current Atherosclerosis Reports

Why is HDL functionally deficient in type 2 diabetes?

(2008) Anatol Kontush et al.   Current Diabetes Reports

Association of Loss-of-Function Mutations in the ABCA1 Gene With High-Density Lipoprotein Cholesterol Levels and Risk of Ischemic Heart Disease

(2008) Ruth Frikke-Schmidt   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

COMPLEMENT FACTOR H VARIANT INCREASES THE RISK FOR EARLY AGE-RELATED MACULAR DEGENERATION

(2008) JANE-MING LIN et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES