Trefoil Factor Family (TFF) Peptides and Their Links to Inflammation: A Re-evaluation and New Medical Perspectives

Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update

(2021) Werner Hoffmann   CURRENT MEDICINAL CHEMISTRY

Molecular Alterations in the Stomach of Tff1-Deficient Mice: Early Steps in Antral Carcinogenesis

(2020) Eva B. Znalesniak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Subcellular Localization of the TFF Peptides xP1 and xP4 in the Xenopus laevis Gastric/Esophageal Mucosa: Different Secretion Modes Reflecting Diverse Protective Functions

(2020) Heinz Schwarz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm

(2020) Mikel Ruterbusch et al.   Annual Review of Immunology

Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome

(2020) Anna Manko-Prykhoda et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

(2020) Jörn Heuer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trefoil factors share a lectin activity that defines their role in mucus

(2020) Michael A. Järvå et al.   Nature Communications

Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm

(2020) Werner Hoffmann   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

(2020) Abdelaziz Ghanemi et al.   Animals

Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions

(2020) Tracy M. Handel et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

(2019) Nayara Braga Emidio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Trefoil Factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids

(2019) Kristen A. Engevik et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli K1

(2019) Alex J. McCarthy et al.   INFECTION AND IMMUNITY

Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways

(2019) Melinda A. Engevik et al.   mBio

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

(2019) Mohammed Soutto et al.   Nature Communications

Different Forms of TFF2, A Lectin of the Human Gastric Mucus Barrier: In Vitro Binding Studies

(2019) Franziska Heuer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Different Forms of TFF3 in the Human Saliva: Heterodimerization with IgG Fc Binding Protein (FCGBP)

(2019) Till Houben et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TFF Peptides xP1 and xP4 Appear in Distinctive Forms in the Xenopus laevis Gastric Mucosa: Indications for Different Protective Functions

(2019) Stürmer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

(2019) Nicole Maloney Belle et al.   Nature Communications

Human Synovia Contains Trefoil Factor Family (TFF) Peptides 1–3 Although Synovial Membrane Only Produces TFF3: Implications in Osteoarthritis and Rheumatoid Arthritis

(2019) Popp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins

(2018) Charlotte Leclaire et al.   FASEB JOURNAL

Three types of metaplasia models through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium

(2018) Hiroto Kinoshita et al.   JOURNAL OF PATHOLOGY

TFF1 antagonizes TIMP-1 mediated proliferative functions in gastric cancer

(2018) Omar M. Omar et al.   MOLECULAR CARCINOGENESIS

Commercial Porcine Gastric Mucin Preparations, also Used as Artificial Saliva, are a Rich Source for the Lectin TFF2: In Vitro Binding Studies

(2018) René Stürmer et al.   CHEMBIOCHEM

Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism

(2018) Li-Yin Hung et al.   Mucosal Immunology

Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes

(2017) Eva Znalesniak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycan-Based Cell Targeting To Modulate Immune Responses

(2017) Timo Johannssen et al.   TRENDS IN BIOTECHNOLOGY

FcGBP was upregulated by HPV infection and correlated to longer survival time of HNSCC patients

(2017) Yating Wang et al.   Oncotarget

Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection

(2017) Roberta Esposito et al.   Frontiers in Cellular and Infection Microbiology

Loss of Tff1 Promotes Pro-Inflammatory Phenotype with Increase in the Levels of RORγt+ T Lymphocytes and Il-17 in Mouse Gastric Neoplasia

(2017) Mohammed Soutto et al.   Journal of Cancer

Heterogeneity of Human CD4+T Cells Against Microbes

(2016) Federica Sallusto   Annual Review of Immunology

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model

(2016) Stefan Thiem et al.   CANCER RESEARCH

Trefoil factor 3 shows anti-inflammatory effects on activated microglia

(2016) Philipp Arnold et al.   CELL AND TISSUE RESEARCH

Increased Cerebral Tff1 Expression in Two Murine Models of Neuroinflammation

(2016) Eva B Znalesniak et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Searching the Evolutionary Origin of Epithelial Mucus Protein Components—Mucins and FCGBP

(2016) Tiange Lang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

(2016) Zina Dubeykovskaya et al.   Nature Communications

TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow

(2015) Louise M. Judd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Differential regional and cellular distribution of TFF3 peptide in the human brain

(2015) Hans-Gert Bernstein et al.   AMINO ACIDS

Trefoil factor 1 expression suppressesHelicobacter pylori-induced inflammation in gastric carcinogenesis

(2015) Mohammed Soutto et al.   CANCER

Current Status on Stem Cells and Cancers of the Gastric Epithelium

(2015) Werner Hoffmann   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)

(2015) WERNER HOFFMANN   INTERNATIONAL JOURNAL OF ONCOLOGY

Trefoil factors (TFFs) are increased in bronchioalveolar lavage fluid from patients with chronic obstructive lung disease (COPD)

(2015) Niels-Erik Viby et al.   PEPTIDES

AGR2, ERp57/GRP58, and some other human protein disulfide isomerases

(2014) S. S. Shishkin et al.   BIOCHEMISTRY-MOSCOW

Porcine Gastric TFF2 is a Mucus Constituent and Differs from Pancreatic TFF2

(2014) René Stürmer et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tff3 is Expressed in Neurons and Microglial Cells

(2014) Ting Fu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Helicobacter pyloriand Gastric Cancer

(2014) Jan Bornschein et al.   DIGESTIVE DISEASES

CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis

(2014) Yoku Hayakawa et al.   GUT

Human Trefoil Factor 2 Is a Lectin That Binds α-GlcNAc-capped Mucin Glycans with Antibiotic Activity againstHelicobacter pylori

(2014) Franz-Georg Hanisch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals

(2014) R W Paterson et al.   Translational Psychiatry

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli

(2013) George M. H. Birchenough et al.   INFECTION AND IMMUNITY

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

A Variant Form of the Human Deleted in Malignant Brain Tumor 1 (DMBT1) Gene Shows Increased Expression in Inflammatory Bowel Diseases and Interacts with Dimeric Trefoil Factor 3 (TFF3)

(2013) Jens Madsen et al.   PLoS One

Trefoil Factor–2 Reverses Airway Remodeling Changes in Allergic Airways Disease

(2012) Simon G. Royce et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased Susceptibility toYersinia enterocoliticaInfection ofTff2Deficient Mice

(2012) Aftab A. Shah et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Evasion of mucosal defenses during Aeromonas hydrophila infection of channel catfish (Ictalurus punctatus) skin

(2012) Chao Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide

(2012) F.-G. Hanisch et al.   GLYCOBIOLOGY

Essential role of gastric gland mucin in preventing gastric cancer in mice

(2012) Fumitoshi Karasawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

(2012) Marsha Wills-Karp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trefoil Factor 2 Negatively Regulates Type 1 Immunity against Toxoplasma gondii

(2012) C. McBerry et al.   JOURNAL OF IMMUNOLOGY

Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2

(2011) Yong Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Trefoil Factor 2 Regulates Airway Remodeling in Animal Models of Asthma

(2011) Simon G. Royce et al.   JOURNAL OF ASTHMA

Loss of TFF1 is associated with activation of NF-κB–mediated inflammation and gastric neoplasia in mice and humans

(2011) Mohammed Soutto et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice

(2011) E Buache et al.   ONCOGENE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans

(2010) Anthony J. Peterson et al.   GASTROENTEROLOGY

Spasmolytic Polypeptide-Expressing Metaplasia and Intestinal Metaplasia: Time for Reevaluation of Metaplasias and the Origins of Gastric Cancer

(2010) James R. Goldenring et al.   GASTROENTEROLOGY

In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase

(2010) L. Xue et al.   GUT

Review: Gp-340/DMBT1 in mucosal innate immunity

(2010) Jens Madsen et al.   Innate Immunity

Human Intestinal TFF3 Forms Disulfide-Linked Heteromers with the Mucus-Associated FCGBP Protein and Is Released by Hydrogen Sulfide

(2010) Timo K. Albert et al.   JOURNAL OF PROTEOME RESEARCH

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

(2010) Malin E. V. Johansson et al.   PLoS One

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori

(2010) Steffen Backert et al.   TRENDS IN MICROBIOLOGY

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

(2009) Daniel K. Podolsky et al.   GASTROENTEROLOGY

IL-9 Promotes IL-13-Dependent Paneth Cell Hyperplasia and Up-Regulation of Innate Immunity Mediators in Intestinal Mucosa

(2009) V. Steenwinckel et al.   JOURNAL OF IMMUNOLOGY

Trefoil Factor Family (TFF) Peptides and Chemokine Receptors: A Promising Relationship

(2009) Werner Hoffmann   JOURNAL OF MEDICINAL CHEMISTRY

Inflaming metastasis

(2009) Alberto Mantovani   NATURE

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice

(2008) S. M. Karam et al.   CELL PROLIFERATION

The trefoil factor family – small peptides with multiple functionalities

(2008) S. Kjellev   CELLULAR AND MOLECULAR LIFE SCIENCES

Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner

(2008) Emer P. Reeves et al.   GASTROENTEROLOGY

 1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol  -glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth

(2008) H. Lee et al.   GLYCOBIOLOGY

Secreted Trefoil Factor 2 Activates the CXCR4 Receptor in Epithelial and Lymphocytic Cancer Cell Lines

(2008) Zinaida Dubeykovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Modulation of Aire regulates the expression of tissue-restricted antigens

(2007) Vivian Kont et al.   MOLECULAR IMMUNOLOGY

Are trefoil factors oncogenic?

(2007) Jo K. Perry et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM