Insights into the modulatory role of cyclosporine A and its research advances in acute inflammation

Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d ‐galactosamine induced acute liver injury

(2020) Zheng Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion

(2020) Paola Venditti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice

(2020) Dahea You et al.   TOXICOLOGICAL SCIENCES

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

(2020) Ana Copaescu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

(2019) Chang-xiong Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Sex Differences in Ischemia/Reperfusion Injury: The Role of Mitochondrial Permeability Transition

(2019) Jasmine A. Fels et al.   NEUROCHEMICAL RESEARCH

Cyclosporine A improves pregnancy outcomes in women with recurrent pregnancy loss and elevated Th1/Th2 ratio

(2019) Ramyar Azizi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased inducible nitric oxide synthase (iNOS) expression in human myocardial infarction

(2019) Verena Wilmes et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)

(2019) Michela Comi et al.   Cellular & Molecular Immunology

Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways

(2019) Li Liu et al.   CELL PROLIFERATION

Regulation by nitric oxide on mitochondrial permeability transition of peaches during storage

(2019) Dandan Huang et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Ghrelin attenuates sepsis-induced acute lung injury by inhibiting the NF-κB, iNOS, and Akt signaling in alveolar macrophages

(2019) Haichong Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transient receptor potential vanilloid 4 is a critical mediator in LPS mediated inflammation by mediating calcineurin/NFATc3 signaling

(2019) Min Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytochrome c: An extreme multifunctional protein with a key role in cell fate

(2019) Roberto Santucci et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ghrelin as an anti-inflammatory and protective agent in ischemia/reperfusion injury

(2019) K. Raghay et al.   PEPTIDES

Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice

(2018) Xixi Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Signaling Pathways in Inflammation and Anti-inflammatory Therapies

(2018) Yiu To Yeung et al.   CURRENT PHARMACEUTICAL DESIGN

A systematic investigation on animal models of cyclosporine A combined with Escherichia coli to simulate the immunosuppressive status of sepsis patients before onset

(2018) Xianbin Kong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CypD-mPTP axis regulates mitochondrial functions contributing to osteogenic dysfunction of MC3T3-E1 cells in inflammation

(2018) Xueqi Gan et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury

(2018) Wesley M. Raup-Konsavage et al.   KIDNEY INTERNATIONAL

Inflammation, Autophagy, and Apoptosis After Myocardial Infarction

(2018) Xianwei Wang et al.   Journal of the American Heart Association

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

(2018) Thomas Briston et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Cyclosporine-A via Suppression of Mitochondrial DNA

(2018) Zhenghua Xiao et al.   MEDICAL SCIENCE MONITOR

Revisiting the Concept of Targeting NFAT to Control T Cell Immunity and Autoimmune Diseases

(2018) Jae-Ung Lee et al.   Frontiers in Immunology

Cyclosporine counteracts endotoxemia-evoked reductions in blood pressure and cardiac autonomic dysfunction via central sGC/MAPKs signaling in rats

(2017) Marwa Y. Sallam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like receptor 5 signaling restrains T-cell/natural killer T-cell activation and protects against concanavalin A-induced hepatic injury

(2017) Lei Wang et al.   HEPATOLOGY

Cyclosporine A attenuates cardiac dysfunction induced by sepsis via inhibiting calcineurin and activating AMPK signaling

(2017) Jingmiao Liu et al.   Molecular Medicine Reports

Attribution of Bax and mitochondrial permeability transition pore on cantharidin-induced apoptosis of Sf9 cells

(2017) Gaofeng Cui et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review

(2017) Skyla A. Duncan et al.   Frontiers in Microbiology

Liver immunology and its role in inflammation and homeostasis

(2016) Mark W Robinson et al.   Cellular & Molecular Immunology

Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance

(2016) Wenyan Xie et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive Review

(2016) Cecilia Beatrice Chighizola et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Cyclosporin A Protects H9c2 Cells Against Chemical Hypoxia-Induced Injury via Inhibition of MAPK Signaling Pathway

(2016) Gang Wang et al.   International Heart Journal

Cyclosporine A in Reperfused Myocardial Infarction

(2016) Filippo Ottani et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

(2016) Gentaro Ikeda et al.   Scientific Reports

Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation

(2015) Rami A. Namas et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclosporine A reduces microvascular obstruction and preserves left ventricular function deterioration following myocardial ischemia and reperfusion

(2015) Jaroslaw Zalewski et al.   BASIC RESEARCH IN CARDIOLOGY

Mechanism of Rhein-Induced Apoptosis in Rat Primary Hepatocytes: Beneficial Effect of Cyclosporine A

(2015) Gati Krushna Panigrahi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cyclophilin-D: a resident regulator of mitochondrial gene expression

(2015) Jeejabai Radhakrishnan et al.   FASEB JOURNAL

Mitochondrial permeability transition increases reactive oxygen species production and induces DNA fragmentation in human spermatozoa

(2015) F. Treulen et al.   HUMAN REPRODUCTION

Beneficial effect of cyclosporine A on traumatic hemorrhagic shock

(2015) Yan Lei et al.   JOURNAL OF SURGICAL RESEARCH

The effect of cyclosporine A in hemorrhagic shock model of rats

(2015) Kyuseok Kim et al.   Journal of Trauma and Acute Care Surgery

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Postconditioning With Cyclosporine A Reduces Early Renal Dysfunction by Inhibiting Mitochondrial Permeability Transition

(2015) Sandrine Lemoine et al.   TRANSPLANTATION

The effect of cyclosporine A in hemorrhagic shock model of rats

(2015) Kyuseok Kim et al.   Journal of Trauma and Acute Care Surgery

Cyclosporine Protects the Heart during Aortic Valve Surgery

(2014) Pascal Chiari et al.   ANESTHESIOLOGY

Interleukin-17 mediates triptolide-induced liver injury in mice

(2014) Xinzhi Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

The effect of cyclosporin-A on peri-operative myocardial injury in adult patients undergoing coronary artery bypass graft surgery: a randomised controlled clinical trial

(2014) DJ Hausenloy et al.   HEART

Ubiquitous protective effects of cyclosporine A in preventing cardiac arrest-induced multiple organ failure

(2014) Martin Cour et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Transcription Factor Nuclear Factor of Activated T Cells c3 Modulates the Function of Macrophages in Sepsis

(2014) Ravi Ranjan et al.   Journal of Innate Immunity

Role of mitochondrial permeability transition in human hepatocellular carcinoma Hep-G2 cell death induced by rhein

(2013) Qiong Du et al.   FITOTERAPIA

Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients

(2013) T.E. Corcoran et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Systemic lupus erythematosus with cytophagic histiocytic panniculitis successfully treated with high-dose glucocorticoids and cyclosporine A

(2013) H Hasegawa et al.   LUPUS

The calcineurin inhibitor cyclosporine A improves lipopolysaccharide-induced vascular dysfunction but does not rescue from cardiovascular collapse in endotoxemic mice

(2013) Mette Stæhr et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients

(2013) Emilie Tourneur et al.   PLoS Pathogens

The Effect of Prethrombolytic Cyclosporine-A Injection on Clinical Outcome of Acute Anterior ST-Elevation Myocardial Infarction

(2012) Samad Ghaffari et al.   Cardiovascular Therapeutics

The imbalance of T helper 17/regulatory T cells and memory B cells during the early post-transplantation period in peripheral blood of living donor liver transplantation recipients under calcineurin inhibitor-based immunosuppression

(2012) Hee Yeon Kim et al.   IMMUNOLOGY

One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice

(2012) X. Wen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Immunosuppressive Activity of Polymeric Micellar Formulation of Cyclosporine A: In Vitro and In Vivo Studies

(2011) Samar Hamdy et al.   AAPS Journal

Crosstalk between central pathways of nitric oxide and carbon monoxide in the hypertensive action of cyclosporine

(2011) Mahmoud M. El-Mas et al.   NEUROPHARMACOLOGY

Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia

(2011) Shubhra Chaudhuri et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

NIM811 Prevents Mitochondrial Dysfunction, Attenuates Liver Injury, and Stimulates Liver Regeneration After Massive Hepatectomy

(2010) Hasibur Rehman et al.   TRANSPLANTATION

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo

(2009) Charay Jennings et al.   Innate Immunity

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

(2009) Ivan Zanoni et al.   NATURE

Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice

(2008) Jian Zhuge et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calcineurin inhibitors down-regulate iNOS expression by destabilising mRNA

(2008) Mari Hämäläinen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE