Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling

Hemodynamic Shear Stress via ROS Modulates PCSK9 Expression in Human Vascular Endothelial and Smooth Muscle Cells and Along the Mouse Aorta

(2015) Zufeng Ding et al.   ANTIOXIDANTS & REDOX SIGNALING

Accurate and reproducible reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT: Comparative study to 3D IVUS and 3D QCA

(2015) Konstantinos Toutouzas et al.   ATHEROSCLEROSIS

Pulsatile flow of a shear-thinning model for blood through a two-dimensional stenosed channel

(2015) N. Nandakumar et al.   EUROPEAN JOURNAL OF MECHANICS B-FLUIDS

Cholesterol Crystals Associate With Coronary Plaque Vulnerability In Vivo

(2015) Yu Kataoka et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease

(2015) Yingguang Li et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of high shear rate in thrombosis

(2015) Lauren D.C. Casa et al.   JOURNAL OF VASCULAR SURGERY

Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography

(2015) Agnese Irkle et al.   Nature Communications

Anatomically correct three-dimensional coronary artery reconstruction using frequency domain optical coherence tomographic and angiographic data: head-to-head comparison with intravascular ultrasound for endothelial shear stress assessment in humans

(2015) Michail I. Papafaklis et al.   EuroIntervention

Reversal of flow between serial bifurcation lesions: insights from computational fluid dynamic analysis in a population-based phantom model

(2015) Peter Barlis et al.   EuroIntervention

In vivo assessment of the relationship between shear stress and necrotic core in early and advanced coronary artery disease

(2015) Jolanda J. Wentzel et al.   EuroIntervention

Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

(2014) Lucas H. Timmins et al.   ANNALS OF BIOMEDICAL ENGINEERING

Effect of shear stress on water and LDL transport through cultured endothelial cell monolayers

(2014) Hongyan Kang et al.   ATHEROSCLEROSIS

Coronary Plaque Structural Stress Is Associated With Plaque Composition and Subtype and Higher in Acute Coronary Syndrome

(2014) Zhongzhao Teng et al.   Circulation-Cardiovascular Imaging

Endothelial Shear Stress and Coronary Plaque Characteristics in Humans

(2014) Rocco Vergallo et al.   Circulation-Cardiovascular Imaging

Relationship between cholesterol crystals and culprit lesion characteristics in patients with stable coronary artery disease: an optical coherence tomography study

(2014) Shunichi Nakamura et al.   Clinical Research in Cardiology

Mechanical properties of human atherosclerotic intima tissue

(2014) Ali C. Akyildiz et al.   JOURNAL OF BIOMECHANICS

Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: Data, modeling, validation, uncertainty and predictions

(2014) Dalin Tang et al.   JOURNAL OF BIOMECHANICS

Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis

(2014) Jinwei Tian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnostic Performance of Noninvasive Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography in Suspected Coronary Artery Disease

(2014) Bjarne L. Nørgaard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Microstructurally Motivated Model of Arterial Wall Mechanics with Mechanobiological Implications

(2013) C. Bellini et al.   ANNALS OF BIOMEDICAL ENGINEERING

Combination of plaque burden, wall shear stress, and plaque phenotype has incremental value for prediction of coronary atherosclerotic plaque progression and vulnerability

(2013) Michel T. Corban et al.   ATHEROSCLEROSIS

Histopathologic Characteristics of Atherosclerotic Coronary Disease and Implications of the Findings for the Invasive and Noninvasive Detection of Vulnerable Plaques

(2013) Jagat Narula et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow

(2013) J. Zhou et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial

(2013) Nikhil V Joshi et al.   LANCET

Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries

(2013) A. Kelly-Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK 2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

(2013) B. Gongol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis

(2013) Dong Ju Son et al.   Nature Communications

A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture

(2012) Natalia Maldonado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Microcalcifications Increase Coronary Vulnerable Plaque Rupture Potential: A Patient-Based Micro-CT Fluid–Structure Interaction Study

(2012) S. H. Rambhia et al.   ANNALS OF BIOMEDICAL ENGINEERING

Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human left coronary arteries

(2012) Farhad Rikhtegar et al.   ATHEROSCLEROSIS

Prediction of Progression of Coronary Artery Disease and Clinical Outcomes Using Vascular Profiling of Endothelial Shear Stress and Arterial Plaque Characteristics

(2012) Peter H. Stone et al.   CIRCULATION

First Presentation of 3-Dimensional Reconstruction and Centerline-Guided Assessment of Coronary Bifurcation by Fusion of X-Ray Angiography and Optical Coherence Tomography

(2012) Shengxian Tu et al.   JACC-Cardiovascular Interventions

The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding

(2012) Natalia Maldonado et al.   JOURNAL OF BIOMECHANICS

Shear stress and advanced atherosclerosis in human coronary arteries

(2012) Frank Gijsen et al.   JOURNAL OF BIOMECHANICS

Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells

(2012) Anna Pfenniger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Coronary Arterial 18F-Sodium Fluoride Uptake

(2012) Marc R. Dweck et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Coronary Wall Shear Stress With Atherosclerotic Plaque Burden, Composition, and Distribution in Patients With Coronary Artery Disease

(2012) Parham Eshtehardi et al.   Journal of the American Heart Association

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries

(2011) Ruben B. Roijers et al.   AMERICAN JOURNAL OF PATHOLOGY

Is arterial wall-strain stiffening an additional process responsible for atherosclerosis in coronary bifurcations?: an in vivo study based on dynamic CT and MRI

(2011) Jacques Ohayon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of intima stiffness and plaque morphology on peak cap stress

(2011) Ali C Akyildiz et al.   Biomedical Engineering Online

Augmented Expression and Activity of Extracellular Matrix-Degrading Enzymes in Regions of Low Endothelial Shear Stress Colocalize With Coronary Atheromata With Thin Fibrous Caps in Pigs

(2011) Yiannis S. Chatzizisis et al.   CIRCULATION

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients With Coronary Artery Disease

(2011) Habib Samady et al.   CIRCULATION

Fusion of optical coherence tomography and coronary angiography ? In vivo assessment of shear stress in plaque rupture

(2011) Christos V. Bourantas et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Imaging the subcellular structure of human coronary atherosclerosis using micro–optical coherence tomography

(2011) Linbo Liu et al.   NATURE MEDICINE

A Prospective Natural-History Study of Coronary Atherosclerosis

(2011) Gregg W. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-21 targets peroxisome proliferators-activated receptor-  in an autoregulatory loop to modulate flow-induced endothelial inflammation

(2011) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High shear stress induces a strain increase in human coronary plaques over a 6-month period

(2011) Frank J.H. Gijsen et al.   EuroIntervention

Shear-induced endothelial cell-cell junction inclination

(2010) Benoît Melchior et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

On the shear-thinning and viscoelastic effects of blood flow under various flow rates

(2010) T. Bodnár et al.   APPLIED MATHEMATICS AND COMPUTATION

Concept of Vulnerable/Unstable Plaque

(2010) Aloke V. Finn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The mechanical triggers of plaque rupture: shear stressvspressure gradient

(2010) Z-Y Li et al.   BRITISH JOURNAL OF RADIOLOGY

In Vivo 3D Distribution of Lipid-Core Plaque in Human Coronary Artery as Assessed by Fusion of Near Infrared Spectroscopy–Intravascular Ultrasound and Multislice Computed Tomography Scan

(2010) Jolanda J. Wentzel et al.   Circulation-Cardiovascular Imaging

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro

(2010) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

(2009) George S. Abela et al.   AMERICAN JOURNAL OF CARDIOLOGY

Patient-specific three-dimensional simulation of LDL accumulation in a human left coronary artery in its healthy and atherosclerotic states

(2009) Ufuk Olgac et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stress phase angle depicts differences in coronary artery hemodynamics due to changes in flow and geometry after percutaneous coronary intervention

(2009) Ryo Torii et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Flow Activation of AMP-Activated Protein Kinase in Vascular Endothelium Leads to Krüppel-Like Factor 2 Expression

(2009) Angela Young et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of apoptosis in LDL transport through cultured endothelial cell monolayers

(2009) Limary M. Cancel et al.   ATHEROSCLEROSIS

In Vivo IVUS-Based 3-D Fluid–Structure Interaction Models With Cyclic Bending and Anisotropic Vessel Properties for Human Atherosclerotic Coronary Plaque Mechanical Analysis

(2009) Chun Yang et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Strain distribution over plaques in human coronary arteries relates to shear stress

(2008) Frank J. H. Gijsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prediction of the Localization of High-Risk Coronary Atherosclerotic Plaques on the Basis of Low Endothelial Shear Stress

(2008) Yiannis S. Chatzizisis et al.   CIRCULATION

Localized α4 Integrin Phosphorylation Directs Shear Stress–Induced Endothelial Cell Alignment

(2008) Lawrence E. Goldfinger et al.   CIRCULATION RESEARCH

Fundamental role of axial stress in compensatory adaptations by arteries

(2008) J.D. Humphrey et al.   JOURNAL OF BIOMECHANICS

Nanomechanical properties of calcification, fibrous tissue, and hematoma from atherosclerotic plaques

(2008) Donna M. Ebenstein et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Localized Elevation of Shear Stress Is Related to Coronary Plaque Rupture

(2008) Yusaku Fukumoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY