Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

Transmural Conduction Is the Predominant Mechanism of Breakthrough During Atrial Fibrillation

(2013) Jens Eckstein et al.   Circulation-Arrhythmia and Electrophysiology

Loss of Continuity in the Thin Epicardial Layer Because of Endomysial Fibrosis Increases the Complexity of Atrial Fibrillatory Conduction

(2013) Sander Verheule et al.   Circulation-Arrhythmia and Electrophysiology

Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue

(2013) Alicja Bukowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

(2013) Dmitry L. Sonin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

(2013) Julian I. Borissoff et al.   PLoS One

Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts

(2012) Aaron N. Snead et al.   FASEB JOURNAL

Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method

(2012) R. LOEFFEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling

(2011) Tetyana G. Voloshenyuk et al.   CYTOKINE

Protease-activated receptors and myocardial infarction

(2011) Silvio Antoniak et al.   IUBMB LIFE

Cardiac Fibroblasts in Cell Culture Systems: Myofibroblasts All Along?

(2011) Stephan Rohr   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The Hemostatic System as a Modulator of Atherosclerosis

(2011) Julian Ilcheff Borissoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal

(2011) Ulrich Schotten et al.   PHYSIOLOGICAL REVIEWS

Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury

(2010) Silvio Antoniak et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fibrillatory Conduction in the Atrial Free Walls of Goats in Persistent and Permanent Atrial Fibrillation

(2010) Sander Verheule et al.   Circulation-Arrhythmia and Electrophysiology

Electropathological Substrate of Long-Standing Persistent Atrial Fibrillation in Patients With Structural Heart Disease

(2010) Maurits A. Allessie et al.   Circulation-Arrhythmia and Electrophysiology

Role of protease-activated receptors in human skin fibrosis and scleroderma

(2010) Ferda Cevikbas et al.   EXPERIMENTAL DERMATOLOGY

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

(2010) Jong-Sup Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts

(2009) Galina S. Bogatkevich et al.   ARTHRITIS AND RHEUMATISM

Is thrombin a key player in the 'coagulation-atherogenesis' maze?

(2009) J. I. Borissoff et al.   CARDIOVASCULAR RESEARCH

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

(2009) Norifumi Takeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Factor Xa: at the crossroads between coagulation and signaling in physiology and disease

(2008) Keren Borensztajn et al.   TRENDS IN MOLECULAR MEDICINE