CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma

Elotuzumab, pomalidomide, and dexamethasone is a very well tolerated regimen associated with durable remission even in very advanced myeloma: a retrospective study from two academic centers

(2020) Dorothea Hose et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever

(2020) Maximilian Amberger et al.   BIOESSAYS

Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities

(2020) Chiara F. Magnani et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

γ-secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma

(2019) Margot J. Pont et al.   BLOOD

A highly soluble Sleeping Beauty transposase improves control of gene insertion

(2019) Irma Querques et al.   NATURE BIOTECHNOLOGY

Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell Receptors

(2018) Julian Clauss et al.   HUMAN GENE THERAPY

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors

(2018) Marta Holstein et al.   MOLECULAR THERAPY

Chimeric Antigen Receptor-T Cells with 4-1BB Co-Stimulatory Domain Present a Superior Treatment Outcome than Those with CD28 Domain Based on Bioinformatics

(2018) Qi Zhong et al.   ACTA HAEMATOLOGICA

Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system

(2018) Michael Hudecek et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Gene Therapy with the Sleeping Beauty Transposon System

(2017) Partow Kebriaei et al.   TRENDS IN GENETICS

T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

(2016) S. A. Ali et al.   BLOOD

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

(2016) Partow Kebriaei et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors

(2016) R Monjezi et al.   LEUKEMIA

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4+ T Cells

(2016) Andreas Gogol-Döring et al.   MOLECULAR THERAPY

The Sleeping Beauty Transposon Vector System for Treatment of Rare Genetic Diseases: An Unrealized Hope?

(2015) Philip Boehme et al.   CURRENT GENE THERAPY

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

piggyBactransposons expressing full-length human dystrophin enable genetic correction of dystrophic mesoangioblasts

(2015) Mariana Loperfido et al.   NUCLEIC ACIDS RESEARCH

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

(2013) Perry B. Hackett et al.   Translational Research

Efficient Sleeping Beauty DNA Transposition From DNA Minicircles

(2013) Nynne Sharma et al.   Molecular Therapy-Nucleic Acids

Efficacy and Safety of Sleeping Beauty Transposon-Mediated Gene Transfer in Preclinical Animal Studies

(2012) Perry B. Hackett et al.   CURRENT GENE THERAPY

Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery

(2012) S Chabot et al.   GENE THERAPY

Transposon-mediated BAC transgenesis in human ES cells

(2012) Maria Rostovskaya et al.   NUCLEIC ACIDS RESEARCH

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

(2011) X. Wang et al.   BLOOD

Nonviral Gene Delivery with the Sleeping Beauty Transposon System

(2011) Zoltán Ivics et al.   HUMAN GENE THERAPY

The Sleeping Beauty transposon system: a non-viral vector for gene therapy

(2011) E. L. Aronovich et al.   HUMAN MOLECULAR GENETICS

The expanding universe of transposon technologies for gene and cell engineering

(2011) Zoltán Ivics et al.   Mobile DNA

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

(2010) Zsuzsanna Izsvák et al.   BIOESSAYS

Recent Advances in Lentiviral Vector Development and Applications

(2010) Janka Mátrai et al.   MOLECULAR THERAPY

A Transposon and Transposase System for Human Application

(2010) Perry B Hackett et al.   MOLECULAR THERAPY

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

(2009) T. VandenDriessche et al.   BLOOD

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system

(2009) X. Xue et al.   BLOOD

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Transposon-mediated genome manipulation in vertebrates

(2009) Zoltán Ivics et al.   NATURE METHODS

CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma

(2008) E. D. Hsi et al.   CLINICAL CANCER RESEARCH

Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu

(2007) Y.-T. Tai et al.   BLOOD

Transcriptional Activities of the Sleeping Beauty Transposon and Shielding Its Genetic Cargo With Insulators

(2007) Oliver Walisko et al.   MOLECULAR THERAPY

Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications

(2007) Zachary C. Hartman et al.   VIRUS RESEARCH