Novel small molecule inhibitor of Kpnβ1 induces cell cycle arrest and apoptosis in cancer cells

The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

(2020) Lei Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

(2019) Jian Yang et al.   ONCOGENE

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells

(2018) Zhi-Chuan Zhu et al.   ONCOGENE

Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair

(2018) Lili Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A tight balance of Karyopherin β1 expression is required in cervical cancer cells

(2018) Sarah Carden et al.   BMC CANCER

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer

(2017) Michiko Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells

(2017) Tamara Stelma et al.   Oncotarget

Structural Biology and Regulation of Protein Import into the Nucleus

(2016) Mary Christie et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

(2015) Giovanni Luca Gravina et al.   BMC CANCER

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

(2015) Donatella Fiore et al.   CANCER BIOLOGY & THERAPY

Targeting nucleocytoplasmic transport in cancer therapy

(2015) Richard Hill et al.   Oncotarget

NFAT as cancer target: Mission possible?

(2014) Jiang-Jiang Qin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Nucleo-cytoplasmic transport as a therapeutic target of cancer

(2014) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Amino acids derived benzoxazepines: Design, synthesis and antitumor activity

(2013) Shailendra Kumar Dhar Dwivedi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer

(2013) S. R. Martens-de Kemp et al.   CLINICAL CANCER RESEARCH

The Nuclear Import Receptor Kpnβ1 and Its Potential as an AntiCancer Therapeutic Target

(2013) Pauline J. van der Watt et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

KPNB1,XPO7and IPO8 Mediate the Translocation ofNF-κB/p65 into the Nucleus

(2013) Peizhou Liang et al.   TRAFFIC

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

(2012) J Etchin et al.   LEUKEMIA

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression

(2011) Michelle F. Maritz et al.   BIOLOGICAL CHEMISTRY

Global enhancement of nuclear localization-dependent nuclear transport in transformed cells

(2011) Henna V. Kuusisto et al.   FASEB JOURNAL

Molecular basis for specificity of nuclear import and prediction of nuclear localization

(2010) Mary Marfori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear Entry of Activated MAPK Is Restricted in Primary Ovarian and Mammary Epithelial Cells

(2010) Elizabeth R. Smith et al.   PLoS One

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

(2009) S. C. Mutka et al.   CANCER RESEARCH

Tumour Necrosis Is an Indicator of Aggressive Biology in Patients with Urothelial Carcinoma of the Upper Urinary Tract

(2009) Richard Zigeuner et al.   EUROPEAN UROLOGY

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER