Article
Pharmacology & Pharmacy
Nirmitee Mulgaonkar, Haoqi Wang, Junrui Zhang, Christopher M. Roundy, Wendy Tang, Sankar Prasad Chaki, Alex Pauvolid-Correa, Gabriel L. Hamer, Sandun Fernando
Summary: This study investigates the antiviral properties of montelukast and telmisartan against the emerging Omicron variant of SARS-CoV-2. Computational methodologies were used to identify these drugs, conventionally used for asthma and hypertension, as potential inhibitors of the virus. The results show that both drugs can effectively inhibit the virus without reaching cytotoxic concentrations, providing a potential strategy for combating the evolving global pandemic.
Review
Medicine, General & Internal
Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin Y. Q. Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri
Summary: This study aimed to describe the extrapulmonary manifestations of SARS-CoV-2 infection, including their frequency, onset, pathogenesis, and association with disease severity. The study found that early manifestations included olfactory and gustatory disturbance, gastrointestinal symptoms, and rash, while later manifestations included multiorgan complications and thromboembolic events. Uncommon complications such as Guillain-Barre syndrome, rhabdomyolysis, otitis media, meningoencephalitis, and spontaneous pneumomediastinum were also identified. In conclusion, there are two phases of extrapulmonary disease in SARS-CoV-2 infection, with the need for a multidisciplinary consensus to approach and define thromboinflammation and cytokine release syndrome.
SINGAPORE MEDICAL JOURNAL
(2023)
Article
Immunology
Nikhil Ram-Mohan, David Kim, Elizabeth J. Zudock, Marjan M. Hashemi, Kristel C. Tjandra, Angela J. Rogers, Catherine A. Blish, Kari C. Nadeau, Jennifer A. Newberry, James Quinn, Ruth O'Hara, Euan Ashley, Hien Nguyen, Lingxia Jiang, Paul Hung, Andra L. Blomkalns, Samuel Yang
Summary: Measurement of SARS-CoV-2 RNA from the plasma of COVID-19 patients using digital polymerase chain reaction can predict disease severity, clinical deterioration, and extrapulmonary complications. It may guide patient triage and management effectively.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Joanna Niedzielska, Monika Chaszczewska-Markowska, Justyna Chojdak-Lukasiewicz, Jakub Berezowski, Seema Kalra, Przemyslaw Jazwiec
Summary: This study presented a case of a previously healthy 37-year-old male patient who developed symptoms of dermatomyositis on the 4th day from the onset of COVID-19. The patient exhibited both skin and muscle manifestations, and testing confirmed SARS-CoV-2 infection. Treatment with corticosteroids and an immunosuppressive agent resulted in improvement of the patient's condition.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medicine, General & Internal
Alessandro Russo, Francesca Serapide, Angela Quirino, Maria Grazia Tarsitano, Nadia Marascio, Riccardo Serraino, Salvatore Rotundo, Giovanni Matera, Enrico Maria Trecarichi, Carlo Torti
Summary: Early recognition and prompt management are crucial for improving survival in COVID-19 patients. The use of fast microbiological techniques is key in promptly identifying the infection and preventing viral spread. Understanding the clinical features and laboratory results at the time of hospitalization can help physicians differentiate COVID-19 from other diseases.
Article
Multidisciplinary Sciences
Ryuta Uraki, Maki Kiso, Shun Iida, Masaki Imai, Emi Takashita, Makoto Kuroda, Peter J. Halfmann, Samantha Loeber, Tadashi Maemura, Seiya Yamayoshi, Seiichiro Fujisaki, Zhongde Wang, Mutsumi Ito, Michiko Ujie, Kiyoko Iwatsuki-Horimoto, Yuri Furusawa, Ryan Wright, Zhenlu Chong, Seiya Ozono, Atsuhiro Yasuhara, Hiroshi Ueki, Yuko Sakai-Tagawa, Rong Li, Yanan Liu, Deanna Larson, Michiko Koga, Takeya Tsutsumi, Eisuke Adachi, Makoto Saito, Shinya Yamamoto, Masao Hagihara, Keiko Mitamura, Tetsuro Sato, Masayuki Hojo, Shin-ichiro Hattori, Kenji Maeda, Riccardo Valdez, Moe Okuda, Jurika Murakami, Calvin Duong, Sucheta Godbole, Daniel C. Douek, Ken Maeda, Shinji Watanabe, Aubree Gordon, Norio Ohmagari, Hiroshi Yotsuyanagi, Michael S. Diamond, Hideki Hasegawa, Hiroaki Mitsuya, Tadaki Suzuki, Yoshihiro Kawaoka
Summary: The replicative ability and pathogenicity of Omicron BA.2 variant is similar to that of BA.1 in rodents, but it shows less pathogenicity compared to early SARS-CoV-2 strains. There is a marked reduction in the neutralizing activity of plasma from individuals who had recovered from COVID-19 and vaccine recipients against BA.2 variant.
Review
Allergy
Niusha Sharifinejad, Samin Sharafian, Sana Salekmoghadam, Marzieh Tavakol, Mostafa Qorbani
Summary: This study investigates the use of montelukast in the treatment and prevention of COVID-19, suggesting its potential as an antiviral drug. More clinical trials are needed to accurately evaluate its effectiveness.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Pierre-Philippe Piche-Renaud, Luc Panetta, Daniel S. Farrar, Charlotte Moore-Hepburn, Olivier Drouin, Jesse Papenburg, Marina Salvadori, Melanie Laffin, Fatima Kakkar, Shaun K. Morris
Summary: This study provides insights into the clinical manifestations of infants infected with SARS-CoV-2, identifying that severe COVID-19 is uncommon in this age group. Comorbid conditions and younger age are associated with hospitalization related to COVID-19 in infants.
Review
Virology
Kenneth Zheng, Gong Feng, Wen-Yue Liu, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng
Summary: This narrative review provides an overview of the current literature about the extrapulmonary manifestations of COVID-19 that may affect the urinary, cardiovascular, gastrointestinal, hematological, hematopoietic, neurological, or reproductive systems. This review also describes the current understanding of the extrapulmonary complications caused by COVID-19 to improve the management and prognosis of patients with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Eman El-Khateeb, Eman I. El-Berri, Esraa M. Mosalam, Mohamed Z. Nooh, Shimaa Abdelsattar, Amira M. Alghamdi, Sarah Alrubia, Mahmoud S. Abdallah
Summary: This study evaluated the effectiveness, tolerability, and safety of combining montelukast therapy with metformin in obese diabetic patients. The results showed that montelukast adjuvant therapy was superior to metformin-only therapy in diabetes control and weight loss, and it was well-tolerated and safe throughout the study duration.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Kacper Nijakowski, Sylvia Wyzga, Nisha Singh, Filip Podgorski, Anna Surdacka
Summary: The COVID-19 pandemic has had a significant impact on oral health, with a high prevalence of oral symptoms reported in infected individuals, including taste alterations, xerostomia, and ulcerations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Felipe Sanchez Tijmes, Constantin Marschner, Paaladinesh Thavendiranathan, Kate Hanneman
Summary: Globally, more than 650 million people have been infected with the SARS-CoV-2 virus, resulting in COVID-19. Cardiac complications, such as myocardial injury and inflammation, have been recognized in the acute infectious and early recovery phase. As the number of acute COVID-19-related deaths decreases, there is growing interest in post-acute sequelae of COVID-19 (PASC) and other long-term cardiovascular complications. Cardiovascular imaging, including MRI, plays a crucial role in detecting cardiovascular manifestations of COVID-19 in both the acute and long-term phases. This review focuses on the role of cardiac MRI in diagnosing and stratifying the risk of patients with acute and chronic cardiovascular manifestations of COVID-19. Evidence level: 4. Technical efficacy: Stage 3.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Pharmacology & Pharmacy
Malvina Hoxha, Calogero C. Tedesco, Silvana Quaglin, Visar Malaj, Linda Pustina, Valerie Capra, Jilly F. Evans, Angelo Sala, G. Enrico Rovati
Summary: The observational retrospective study suggests that the use of montelukast may be protective against incident cardiac ischemic events in older asthmatic patients. Analyses indicate that exposure to montelukast remains a significant protective factor for incident ischemic events, leading to a considerable risk reduction. The event-free Kaplan-Meier survival curves confirm the lower cardiovascular event incidence in patients exposed to montelukast.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Batil Alonazi, Ahmed M. Farghaly, Mohamed A. Mostafa, Jehad A. Al-Watban, Salah A. Zindani, Feras Altaimi, Moram A. Fagiry, Mustafa Z. Mahmoud
Summary: During the COVID-19 pandemic, the frequency of neurological manifestations has increased, with brain MRI proving to be a sensitive imaging modality for diagnosing viral encephalitides. The study found significant impact of brain MRI in patients with SARS-CoV-2 pneumonia, especially in those with non-focal neurological manifestations and declining Glasgow Coma Scale (GCS).
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Angelo Milano, Konstantinos Efthymakis, Damiano D'Ardes, Marco Tana, Elena Mazzotta, Giulia De Febis, Francesco Laterza, Pierluigi Tarquini, Enrico Marini, Ettore Porreca, Francesco Cipollone, Matteo Neri
Summary: This study investigates gastrointestinal symptoms in COVID-19 patients and finds that these symptoms may be part of the infection. Although patients with gastrointestinal symptoms require faster hospital admission, prognosis is not affected.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Food Science & Technology
Deepa Shah, Manav Gandhi, Arun Kumar, Natalia Cruz-Martins, Rohit Sharma, Sujit Nair
Summary: This article reviews the health-beneficial effects of dietary polyphenols in preventing cancer and highlights their molecular mechanisms, including the modulation of ncRNAs. It also summarizes the current status of clinical trials with these polyphenols.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Hayder Mutter Al-kuraishy, Ali Ismail Al-Gareeb, Gomaa Mostafa-Hedeab, Rupal Dubey, Pranav Kumar Prabhakar, Gaber El-Saber Batiha
Summary: COVID-19 is caused by the SARS-CoV-2 virus, which has infected over 245.37 million people and caused over 4.9 million deaths globally. Diabetes mellitus (DM) and its complications are major health concerns with a high growth rate, affecting one in 11 adults and projected to reach 642 million cases by 2040. DM and its complications are associated with the severity and mortality of COVID-19, and the infection may worsen existing cardiovascular conditions in older individuals.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Neurosciences
Hayder M. M. Al-kuraishy, Ali I. Al-Gareeb, Ajeet Kaushik, Malgorzata Kujawska, Eman A. Ahmed, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) involves the progressive loss of dopaminergic neurons due to neurodegeneration, with the presence of Lewy bodies and inflammation in the brain. The neurotropism of SARS-CoV-2 and its induction of cytokine storm and neuroinflammation may contribute to PD development. However, overexpression of alpha-synuclein in PD patients may limit SARS-CoV-2 neuroinvasion and neuron degeneration, despite the virus accelerating alpha-synuclein aggregation. Further studies are needed to authenticate the potential link between COVID-19 and PD. Additionally, graphene-based nanoscale platforms may offer antiviral and anti-amyloid strategies against PD in the context of controlling the COVID-19 pandemic.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Letter
Cell Biology
Hayder. M. M. Al-Kuraishy, Ali. I. I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha
CELL STRESS & CHAPERONES
(2023)
Review
Cell Biology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Yaser Hosny Ali Elewa, Mahmoud Hosny Zahran, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) is a degenerative brain disorder characterized by the loss of dopamine neurons in the substantia nigra and the accumulation of Lewy bodies and α-synuclein in the brain. Patients with PD often have deficiencies in vitamins such as folate, vitamin B6, and vitamin B12, leading to increased levels of homocysteine in the bloodstream, which may contribute to the development and progression of PD through oxidative and inflammatory pathways. Hyperhomocysteinemia is implicated in neurodegenerative disorders and triggers PD through various mechanisms, including oxidative stress, mitochondrial dysfunction, apoptosis, and endothelial dysfunction. Inflammatory signaling pathways like NF-kappa B and NLRP3 inflammasome are also involved in the pathogenesis of PD. In conclusion, hyperhomocysteinemia plays a role in the neuropathology of PD by directly inducing degeneration of dopamine neurons or indirectly activating inflammatory signaling pathways.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Letter
Medicine, General & Internal
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Maisra M. El-Bouseary, Gaber El-Saber Batiha
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Review
Endocrinology & Metabolism
Mohammed Alrouji, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Human islet amyloid polypeptide (hIAPP) plays a role in both type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). Increased levels of hIAPP in T2DM patients can lead to the development and progression of AD. Various mechanisms, including oxidative stress and immune response, contribute to the aggregation of hIAPP and increase the risk of AD. Dipeptidyl peptidase 4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) agonists can attenuate AD in T2DM by inhibiting the expression and deposition of hIAPP.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Multidisciplinary Sciences
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Sumaiah J. Alarfaj, Rasha Khalifah Al-Akeel, Hani Faidah, Maisra M. El-Bouseary, Jean-Marc Sabatier, Michel De Waard, Thanaa A. El-Masry, Gaber El-Saber Batiha
Summary: Patients with COVID-19 have reduced serum testosterone levels, which is associated with the development of erectile dysfunction (ED). In this case-controlled study, COVID-19 patients with long COVID (LC) were found to have lower levels of total testosterone (TT), free testosterone (FT), and free androgenic index (FAI) compared to healthy controls. These findings suggest a causal link between COVID-19 and ED in LC patients.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Luay Alkazmi, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Scavenger receptor type B I (SR-BI) functions as a major receptor for high-density lipoprotein (HDL) and also plays a role in the entry of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). SR-BI, colocalized with angiotensin-converting enzyme 2 (ACE2), facilitates viral internalization. Reduced SR-BI levels during COVID-19 may be due to direct invasion by SARS-CoV-2 or upregulation of pro-inflammatory cytokines and high angiotensin II (AngII). Further studies are needed to understand the potential protective role of SR-BI in COVID-19.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Immunology
Hayder M. M. Al-kuraishy, Nawar R. R. Hussien, Marwa S. S. Al-Niemi, Esraa H. H. Fahad, Ali K. K. Al-Buhadily, Ali I. I. Al-Gareeb, Sadiq M. M. Al-Hamash, Christos Tsagkaris, Marios Papadakis, Athanasios Alexiou, Gaber El-Saber Batiha
Summary: Covid-19 is associated with cardio-metabolic disorders, including dyslipidemia, dysregulation of high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Noteworthy changes in lipid profile suggest that it could serve as a possible biomarker for the diagnosis and management of Covid-19.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Immunology
Aseel Awad Alsaidan, Hayder M. M. Al-Kuraishy, Ali I. I. Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Khalid Adel Alsayed, Hebatallah M. M. Saad, Gaber El-Saber Batiha
Summary: COVID-19 infection is linked to the development of acute coronary syndrome, including unstable angina and myocardial infarction. Additionally, the infection may lead to non-obstructive coronary disorders and can affect the stability of coronary atherosclerotic plaques through inflammation.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Cell Biology
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Asmaa A. Khalifa, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of phosphorylated tau proteins and amyloid beta (A beta) deposition. NEP inhibitors might have both beneficial and deleterious effects on AD neuropathology. Clinical studies have shown promising safety findings regarding the use of ARNI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
H. M. Al-Kuraishy, R. R. ABD Hasan, A. I. A. Al-Gareeb, S. S. Aggad, A. S. M. Aljohani, I. M. El-Ashmawy, E. Elekhnawy, S. A. Mostafa, W. A. Negm, G. E. Batiha
Summary: This study aimed to determine whether alpha-lipoic acid (ALA) and vitamin C can protect mice against the liver damage caused by methotrexate (MTX). The results showed that pretreatment with ALA and vitamin C dose-dependently increased the levels of glutathione (GSH) and superoxide dismutase (SOD), significantly decreased the levels of malondialdehyde (MDA), alanine transaminase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), and improved liver histological architecture. These findings suggest that ALA and vitamin C are effective in treating MTX-induced liver damage.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Marwa H. Jawad, Majid S. Jabir, Kamile Ozturk, Ghassan M. Sulaiman, Mosleh M. Abomughaid, Salim Albukhaty, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Waleed K. Al-Azzawi, Mazin A. A. Najm, Sabrean F. Jawad
Summary: Gold nanoparticles (GNPs) loaded with tumor necrosis factor-alpha (TNF-alpha) and combined with doxorubicin can induce both autophagy and apoptosis in breast cancer cells. The mitogen-activated protein kinase signaling pathway is affected by the GNPs, leading to decreased p-AKT and increased p-JNK1/2. These results suggest that TNF- and doxorubicin-loaded GNPs may provide a therapeutic option as a nanomedicine to inhibit the proliferation of breast cancer.
NANOTECHNOLOGY REVIEWS
(2023)