Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

(2020) Marialuisa Moccia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoselective Hydrogenation of 6‐alkynyl‐3‐fluoro‐2‐pyridinaldoxime: Access to first‐in‐class 6‐alkyl‐3‐Fluoro‐2‐pyridinaldoxime as Reactivator of Sarin‐Inhibited AChE with increased BBB Permeability

(2020) Rachid Baati et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation

(2020) Naga Rajiv Lakkaniga et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

(2020) André-Guilhem Calas et al.   Biomolecules

Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

(2020) Marjolein Heymans et al.   Fluids and Barriers of the CNS

Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression

(2020) Naga Rajiv Lakkaniga et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First step to the improvement of the blood brain barrier passage of atazanavir encapsulated in sustainable bioorganic vesicles

(2020) Florian Nolay et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lead identification and characterization of hTrkA type 2 inhibitors

(2019) Govindan Subramanian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors

(2019) Shengyang Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Exploration of Chirality for Improved Druggability within the Human Kinome

(2019) Debasmita Saha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application

(2018) Wei Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation

(2016) Wei Yan et al.   Chemical Biology & Drug Design

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain

(2016) Sarah E. Skerratt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

(2016) Maria Menichincheri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation

(2016) Wei Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology

(2015) Brendan Frett et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluation of aromatic 6-substituted thienopyrimidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria

(2015) Jennifer L. Woodring et al.   MedChemComm

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies

(2014) Brendan Frett et al.   MedChemComm

TRKing Down an Old Oncogene in a New Era of Targeted Therapy

(2014) Aria Vaishnavi et al.   Cancer Discovery

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

TrkA Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry

(2012) E. Sanchez-Ortiz et al.   JOURNAL OF NEUROSCIENCE

TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

(2012) Kwok-On Lai et al.   NATURE NEUROSCIENCE

The lighter side of BDNF

(2011) Emily E. Noble et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Improved Survival, Vascular Differentiation and Wound Healing Potential of Stem Cells Co-Cultured with Endothelial Cells

(2011) Dora C. S. Pedroso et al.   PLoS One

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

(2009) Mark P. Mattson   Annals of the New York Academy of Sciences

Trk kinase inhibitors as new treatments for cancer and pain

(2009) Tao Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS