ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD

Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

(2021) Haoxi Wu et al.   DEVELOPMENTAL CELL

Mechanism of membrane-curvature generation by ER-tubule shaping proteins

(2021) Ning Wang et al.   Nature Communications

STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?

(2021) Judith A. Smith   Frontiers in Immunology

FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes

(2021) Marc Siggel et al.   Journal of Physical Chemistry Letters

Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress

(2020) Marisa Loi et al.   Autophagy

Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy

(2020) Jonathan A. Stefely et al.   Autophagy

FAM 134B oligomerization drives endoplasmic reticulum membrane scission for ER ‐phagy

(2020) Xiao Jiang et al.   EMBO JOURNAL

BPIFB3 regulates ER morphology to facilitate flavivirus replication

(2020) Azia S. Evans et al.   JOURNAL OF VIROLOGY

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

(2020) Jin Rui Liang et al.   CELL

Deep learning approach for quantification of organelles and misfolded polypeptides delivery within degradative compartments

(2020) Diego Morone et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alpha1-Antitrypsin Deficiency

(2020) Pavel Strnad et al.   NEW ENGLAND JOURNAL OF MEDICINE

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

(2020) John Fielden et al.   Nature Communications

CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy

(2020) Thaddaeus Mutugi Nthiga et al.   EMBO JOURNAL

MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B

(2020) Laura Cinque et al.   EMBO JOURNAL

ER-phagy: Eating the Factory

(2020) Maurizio Molinari   MOLECULAR CELL

A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance

(2020) Dan Zhao et al.   MOLECULAR CELL

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

(2020) Keisuke Mochida et al.   Nature Communications

Differential expression of full length and N-terminally truncated FAM134B isoforms in normal physiology and cancer

(2020) Umur Keleş et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Atg8-mediated super-assembly of Atg40 induces local ER remodeling in reticulophagy

(2020) Keisuke Mochida et al.   Autophagy

Globular adiponectin alleviates chronic intermittent hypoxia-induced H9C2 cardiomyocytes apoptosis via ER-phagy induction

(2020) Qiang Zhang et al.   CELL CYCLE

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Snf1 AMPK positively regulates ER-phagy via expression control of Atg39 autophagy receptor in yeast ER stress response

(2020) Tomoaki Mizuno et al.   PLoS Genetics

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

(2020) Madlen Stephani et al.   eLife

Selective Autophagy by Close Encounters of the Ubiquitin Kind

(2020) Anna Vainshtein et al.   Cells

Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis

(2020) Michelle M. Cooley et al.   Cellular and Molecular Gastroenterology and Hepatology

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

(2020) Amelia E Ohnstad et al.   EMBO JOURNAL

Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth

(2020) José Wojnacki et al.   Cell Reports

Characterization of constitutive ER-phagy of excess membrane proteins

(2020) Zhanna Lipatova et al.   PLoS Genetics

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies

(2020) Jonathan P. Davies et al.   ACS Infectious Diseases

ER-Phagy and Its Role in ER Homeostasis in Plants

(2020) Yan Bao et al.   Plants-Basel

The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties

(2019) Ida Marie Zobbe Sjøgaard et al.   BIOCHEMICAL JOURNAL

CDK5RAP3, a UFL1 substrate adaptor, is critical for liver development

(2019) Rui Yang et al.   DEVELOPMENT

Reconstituting the reticular ER network – mechanistic implications and open questions

(2019) Ning Wang et al.   JOURNAL OF CELL SCIENCE

Ribosomal protein RPL26 is the principal target of UFMylation

(2019) Christopher P. Walczak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperoning Endoplasmic Reticulum–Associated Degradation (ERAD) and Protein Conformational Diseases

(2019) Patrick G. Needham et al.   Cold Spring Harbor Perspectives in Biology

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways

(2019) Ilaria Fregno et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Emerging Principles of Selective ER Autophagy

(2019) Simon Wilkinson   JOURNAL OF MOLECULAR BIOLOGY

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

(2019) Haruka Chino et al.   MOLECULAR CELL

Compartmentalization and Selective Tagging for Disposal of Misfolded Glycoproteins

(2019) Marina Shenkman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy

(2019) Ramachandra M. Bhaskara et al.   Nature Communications

DeepPhagy: a deep learning framework for quantitatively measuring autophagy activity in Saccharomyces cerevisiae

(2019) Ying Zhang et al.   Autophagy

Plant Selective Autophagy - Still an uncharted territory with a lot of hidden gems

(2019) Madlen Stephani et al.   JOURNAL OF MOLECULAR BIOLOGY

The N-Degron Pathway Mediates ER-phagy

(2019) Chang Hoon Ji et al.   MOLECULAR CELL

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates

(2019) Corey N. Cunningham et al.   MOLECULAR CELL

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

(2019) Yixian Cui et al.   SCIENCE

Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages

(2019) Ulrich Koenig et al.   Autophagy

Emerging lysosomal pathways for quality control at the endoplasmic reticulum

(2019) Chiara De Leonibus et al.   FEBS LETTERS

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

AtSec62 is critical for plant development and is involved in endoplasmic reticulum (ER)‐phagy in Arabidopsis thaliana

(2019) Shuai Hu et al.   Journal of Integrative Plant Biology

The Atlastin ER-shaping proteins facilitate Zika virus replication

(2019) Blandine Monel et al.   JOURNAL OF VIROLOGY

ER-phagy and human diseases

(2019) Christian A. Hübner et al.   CELL DEATH AND DIFFERENTIATION

UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis

(2019) Lihui Wang et al.   CELL RESEARCH

Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells

(2019) Yangjie Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation in health and disease – from substrate to organism

(2019) Asmita Bhattacharya et al.   JOURNAL OF CELL SCIENCE

Selective Autophagy Receptors in Neuronal Health and Disease

(2019) Owen Conway et al.   JOURNAL OF MOLECULAR BIOLOGY

The viral F-box protein P0 induces an ER-derived autophagy degradation pathway for the clearance of membrane-bound AGO1

(2019) Simon Michaeli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Diversification of ER Stress Responses in Arabidopsis

(2019) Noelia Pastor-Cantizano et al.   TRENDS IN BIOCHEMICAL SCIENCES

ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress

(2019) Marisa Loi et al.   Nature Communications

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

(2019) Jasmin A Schäfer et al.   EMBO JOURNAL

The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides

(2018) Concetta Guerra et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides

(2018) Timothy J. Bergmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network

(2018) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

(2018) Yajing Peng et al.   AGING CELL

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Atlastins remodel the endoplasmic reticulum for selective autophagy

(2018) Jin Rui Liang et al.   JOURNAL OF CELL BIOLOGY

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

(2018) Mark L. Schultz et al.   Nature Communications

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

(2018) Alison Forrester et al.   EMBO JOURNAL

The atlastin membrane anchor forms an intramembrane hairpin that does not span the phospholipid bilayer

(2018) Miguel A. Betancourt-Solis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation

(2018) Dara E. Leto et al.   MOLECULAR CELL

The Local Phosphate Deficiency Response Activates ER Stress-dependent Autophagy

(2018) Christin Naumann et al.   PLANT PHYSIOLOGY

Noncanonical autophagy at ER exit sites regulates procollagen turnover

(2018) Shakib Omari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope

(2018) Adrian B. Mehrtash et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Early Events in the Endoplasmic Reticulum Unfolded Protein Response

(2018) Steffen Preissler et al.   Cold Spring Harbor Perspectives in Biology

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

(2017) Markus Tschurtschenthaler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Membrane fission by protein crowding

(2017) Wilton T. Snead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

A prominent role of PDIA6 in processing of misfolded proinsulin

(2016) Dhana G. Gorasia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Protease Ste24 Clears Clogged Translocons

(2016) Tslil Ast et al.   CELL

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice

(2016) Hua Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga

(2016) Abhilash I. Chiramel et al.   JOURNAL OF INFECTIOUS DISEASES

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Mechanistic insights into selective autophagy pathways: lessons from yeast

(2016) Jean-Claude Farré et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Five Questions (with their Answers) on ER-Associated Degradation

(2016) Giorgia Brambilla Pisoni et al.   TRAFFIC

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

(2016) Richard T. Timms et al.   Nature Communications

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

(2016) Rowena DeJesus et al.   eLife

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis

(2015) Kaiyu He et al.   MOLECULAR BIOLOGY OF THE CELL

FGF signalling regulates bone growth through autophagy

(2015) Laura Cinque et al.   NATURE

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

(2015) Laura Antonucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-linked sugar-regulated protein folding and quality control in the ER

(2015) Abla Tannous et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Role for Macro-ER-Phagy in ER Quality Control

(2015) Zhanna Lipatova et al.   PLoS Genetics

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy

(2015) David A. Tumbarello et al.   PLoS Pathogens

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

A novel missense mutation confirms ATL3 as a gene for hereditary sensory neuropathy type 1

(2014) Dirk Fischer et al.   BRAIN

Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3

(2014) Uwe Kornak et al.   BRAIN

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery

(2014) S. Schuck et al.   JOURNAL OF CELL SCIENCE

ERQC Autophagy: Yet Another Way to Die

(2014) Alexander Buchberger   MOLECULAR CELL

Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR

(2014) Scott A. Houck et al.   MOLECULAR CELL

Targeted protein destabilization reveals an estrogen-mediated ER stress response

(2014) Kanak Raina et al.   Nature Chemical Biology

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

(2013) Jean-Claude Farré et al.   EMBO REPORTS

Regulation of ER-phagy by a Ypt/Rab GTPase module

(2013) Zhanna Lipatova et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

(2012) Natalia von Muhlinen et al.   MOLECULAR CELL

Degradation of the Endoplasmic Reticulum by Autophagy during Endoplasmic Reticulum Stress in Arabidopsis

(2012) Y. Liu et al.   PLANT CELL

A New Type of Compartment, Defined by Plant-Specific Atg8-Interacting Proteins, Is Induced upon Exposure of Arabidopsis Plants to Carbon Starvation

(2012) A. Honig et al.   PLANT CELL

SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line

(2011) Satoshi Ninagawa et al.   CELL STRUCTURE AND FUNCTION

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Protein disulfide isomerases contribute differentially to the endoplasmic reticulum–associated degradation of apolipoprotein B and other substrates

(2011) Sarah Grubb et al.   MOLECULAR BIOLOGY OF THE CELL

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

(2011) G. Thibault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum

(2010) Won Jae Huh et al.   GASTROENTEROLOGY

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LSsubstrates

(2010) Riccardo Bernasconi et al.   JOURNAL OF CELL BIOLOGY

Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes

(2010) W. Jia et al.   JOURNAL OF IMMUNOLOGY

The Autophagic Degradation of Chloroplasts via Rubisco-Containing Bodies Is Specifically Linked to Leaf Carbon Status But Not Nitrogen Status in Arabidopsis

(2010) M. Izumi et al.   PLANT PHYSIOLOGY

Cyclosporine A-Sensitive, Cyclophilin B-Dependent Endoplasmic Reticulum-Associated Degradation

(2010) Riccardo Bernasconi et al.   PLoS One

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy

(2009) Lianwu Fu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

RAB26 and RAB3D Are Direct Transcriptional Targets of MIST1 That Regulate Exocrine Granule Maturation

(2009) X. Tian et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection

(2009) Yoshihito Ishida et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

(2009) Ingo Kurth et al.   NATURE GENETICS

A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum

(2008) Riccardo Bernasconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE

Sequestration of Mutated α1-Antitrypsin into Inclusion Bodies Is a Cell-protective Mechanism to Maintain Endoplasmic Reticulum Function

(2007) Susana Granell et al.   MOLECULAR BIOLOGY OF THE CELL