Review
Biochemistry & Molecular Biology
Maria Giovanna Scioli, Sonia Terriaca, Elena Fiorelli, Gabriele Storti, Giulia Fabbri, Valerio Cervelli, Augusto Orlandi
Summary: Cancer stem cells and extracellular vesicles play crucial roles in tumor growth, progression, metastasis, drug resistance, and disease relapse, making them potential targets for therapy and drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yoshitaka Kiya, Yusuke Yoshioka, Yuichi Nagakawa, Takahiro Ochiya
Summary: Extracellular vesicles (EVs) are lipid bilayer particles secreted by various cells in the body. They interact with recipient cells and modulate biological functions by transporting cargoes such as nucleic acids and proteins. They play a role in tumor progression by stimulating signaling pathways, regulating immune system activation, and establishing premetastatic niches. EVs express immune checkpoint molecules, allowing tumor cells to evade immune cell attack and acquire resistance to immune checkpoint inhibitors. This review discusses the association between EVs and tumor progression through the immune system, as well as the clinical application of EVs as biomarkers and therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rafal Szatanek, Monika Baj-Krzyworzeka
Summary: Cancer metastasis involves complex interactions between various cell types and the tumor microenvironment, with tumor cells releasing proteins and nucleic acids through extracellular vesicles to facilitate dissemination. This process plays a crucial role in tumor progression and escape from immune surveillance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xin Zhang, Yi Liu, Lei Dai, Gang Shi, Jie Deng, Qiang Luo, Qian Xie, Lin Cheng, Chunlei Li, Yi Lin, Qingnan Wang, Ping Fan, Hantao Zhang, Xiaolan Su, Shuang Zhang, Yang Yang, Xun Hu, Qiyong Gong, Dechao Yu, Lei Zheng, Hongxin Deng
Summary: BATF2 has been shown to inhibit the growth of glioma and the recruitment of myeloid-derived suppressor cells. Extracellular vesicles from BATF2-overexpressing cells were found to inhibit MDSCs chemotaxis, and the abundance of BATF2-positive EVs in plasma can distinguish different stages of glioma. This study provides insights into the regulatory functions of BATF2 and its potential prognostic value in glioma.
Review
Oncology
Manuel Linder, Elke Pogge von Strandmann
Summary: Intracellular HSP70 plays a crucial role in cellular stress responses, while in cancer, overexpressed HSP70 can translocate to the extracellular milieu as an important modulator of tumor-associated immune cells. T-EVs released by tumor cells contain DAMPs, with HSP70 triggering anti-tumor immune responses, but also potentially promoting tumor growth. The mechanisms of HSP70 translocation and its impact on tumor-associated immune cells in the tumor microenvironment are key elements to consider for potential therapeutic interventions in cancer treatment.
Article
Immunology
Seyedeh Alia Moosavian, Maryam Hashemi, Leila Etemad, Sara Daneshmand, Zahra Salmasi
Summary: Exosomes play a crucial role in early diagnosis and various functions related to angiogenesis, immune modulation, migration, metastasis, chemotherapy resistance, and tumor progression in melanoma. Natural exosomes have the potential to be utilized as nanocarriers and cancer vaccines for more efficient cancer treatment in the era of novel bioengineering and immunotherapy approaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Xi Liu, Qian Wei, Lu Lu, Shengnan Cui, Kui Ma, Wenhua Zhang, Fang Ma, Haihong Li, Xiaobing Fu, Cuiping Zhang
Summary: Inflammatory diseases caused by immune system disorders are a major public health concern. Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) have shown great potential in immune modulation and offer a promising solution for the treatment of inflammatory diseases. Despite being in the early stages of research, MSC-EVs have been found to regulate the activities of innate and adaptive immune cells and have been tested in clinical trials for inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Shenglong Li, Wei Wang
Summary: Bone is a common site for metastasis, providing a favorable environment for the growth of tumor cells. Bone metastasis is a common complication in cancer patients, with EVs potentially playing a role in the pathological exchange between tumors and the bone microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Qi Li, Suna Cai, Mengjiao Li, Kab Ibrahim Salma, Xiaojie Zhou, Feiyu Han, Jinzhao Chen, Ting Huyan
Summary: The article discusses the effects of tumor-derived extracellular vesicles on immune cells and summarizes their research progress in tumor immunotherapy and diagnosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Pina Fusco, Anna Fietta, Maria Rosaria Esposito, Luca Zanella, Sara Micheli, Angelica Bastianello, Lorenzo Bova, Giulia Borile, Giuseppe Germano, Elisa Cimetta
Summary: Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. The role of hypoxic EVs and their miR-210-3p cargo enrichment in promoting Neuroblastoma (NB) dissemination was investigated. The study found that hypoxic EVs were more potent in inducing NB cells migration and colony formation, and miR-210-3p was identified as the most abundant miRNA in the cargo of hypoxic EVs. Overexpression of miR-210-3p in normoxic EVs conferred them pro-metastatic features, while miR-210-3p silencing suppressed the metastatic ability of hypoxic EVs both in vitro and in vivo.
CELL AND BIOSCIENCE
(2023)
Review
Medicine, Research & Experimental
Jafar Rezaie, Mahdi Ahmadi, Reyhaneh Ravanbakhsh, Behnam Mojarad, Shadi Mahbubfam, Shadi Abdolrahman Shaban, Kosar Shadi, Nesa Janamo Berenjabad, Tahereh Etemadi
Summary: The communication between tumor cells and resident cells in the tissue environment is mediated through the secretion of particles called extracellular vesicles (EVs). These EVs play vital roles in tumorigenesis, including pre-metastatic niche formation and organotropic metastasis, by altering the tissue microenvironment and inducing phenotypic alterations in cells. EVs have potential therapeutic applications in cancer management as targeted therapy, cell-free therapy, drug delivery system, and diagnostic biomarker.
Article
Immunology
Hannah J. Loghry, Noelle A. Sondjaja, Sarah J. Minkler, Michael J. Kimber
Summary: Lymphatic filariasis (LF) is a mosquito-borne disease caused by filarial nematodes including Brugia malayi. Current control strategies rely on mass drug administration programs, but established infections are incurable. This study found that parasite-derived galectins have immunomodulatory effects and induce immune phenotypes consistent with chronic LF infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Simona Pompili, Antonella Vetuschi, Roberta Sferra, Alfredo Cappariello
Summary: This article discusses the issue of drug resistance in cancer treatment, arguing that resistance is closely related to multiple mechanisms, including the expression of transporter proteins, mutations in oncogenes and transcription factors, and the role of extracellular vesicles.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Danilo Marimpietri, Irma Airoldi, Angelo Corso Faini, Fabio Malavasi, Fabio Morandi
Summary: Extracellular vesicles play a significant role in cancer, transporting specific cargoes and regulating cellular activities in normal and tumor tissues. Their ability to interact with the tumor microenvironment and modulate anti-tumor immune response, tumorigenesis, tumor growth, metastasis and drug resistance highlights their potential clinical relevance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Qiujun Zhou, Yan Yan, Yuanyan Li, Hongyang Fu, Dingqi Lu, Zhaoyi Li, Yihan Wang, Jinhui Wang, Haijia Zhu, Jianlei Ren, Hongbin Luo, Maocan Tao, Yi Cao, Shenyu Wei, Shasha Fan
Summary: Tumor-derived extracellular vesicles (EVs) play a crucial role in regulating the immune response and impacting the progression of melanoma. EV-based therapy shows promise as a potential strategy for melanoma treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Meeting Abstract
Biophysics
Mehdi Roein-Peikar, Farhan Chowdhury, Benjamin Leslie, Seongjin Park, Qian Xu, Taekjip Ha
BIOPHYSICAL JOURNAL
(2016)
Article
Chemistry, Multidisciplinary
Farhan Chowdhury, Isaac T. S. Li, Thuy T. M. Ngo, Benjamin J. Leslie, Byoung Choul Kim, Joshua E. Sokoloski, Elizabeth Weiland, Xuefeng Wang, Yann R. Chemla, Timothy M. Lohman, Taekjip Ha
Article
Chemistry, Multidisciplinary
Ahmad Z. Qamar, Kshitij Amar, Punit Kohli, Farhan Chowdhury, Mohtashim H. Shamsi
Article
Multidisciplinary Sciences
Xuefeng Wang, Zainab Rahil, Isaac T. S. Li, Farhan Chowdhury, Deborah E. Leckband, Yann R. Chemla, Taekjip Ha
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Farhan Chowdhury, Sultan Doganay, Benjamin J. Leslie, Rishi Singh, Kshitij Amar, Bhavana Talluri, Seongjin Park, Ning Wang, Taekjip Ha
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Review
Engineering, Biomedical
Ananya Barui, Farhan Chowdhury, Abhay Pandit, Pallab Datta
Article
Biochemistry & Molecular Biology
Kshitij Amar, Ian I. Suni, Farhan Chowdhury
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Bhavana Talluri, Kshitij Amar, Michael Saul, Tasnim Shireen, Vjollca Konjufca, Jian Ma, Taekjip Ha, Farhan Chowdhury
Article
Biology
Christopher T. Mandrell, Torrey E. Holland, James E. Wheeler, Sakineh M. A. Esmaeili, Kshitij Amar, Farhan Chowdhury, Poopalasingam Sivakumar
Article
Chemistry, Multidisciplinary
Majid Sharifi, Qian Bai, Mohammad Mahdi Nejadi Babadaei, Farhan Chowdhury, Mahbub Hassan, Akbar Taghizadeh, Hossein Derakhshankhah, Suliman Khan, Anwarul Hasan, Mojtaba Falahati
Summary: Bioprinting technique enables the study of biological changes in response to pharmacological compounds, specifically in breast cancer tissue for personalized medicine. Challenges in reproducibility of 3D bioprinted breast cancer tissue are mainly due to uncertainty in scaffold materials and lack of printing methods. Future applications of bioprinted cancer models may facilitate rapid and precise drug screening in breast cancer research.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Rashid Ahmed, Tariq Zaman, Farhan Chowdhury, Fatima Mraiche, Muhammad Tariq, Irfan S. Ahmad, Anwarul Hasan
Summary: Single-cell RNA sequencing techniques have the potential to explore the development and progression of tumors by analyzing the transcriptome at the single-cell level. These techniques provide a better understanding of the cellular diversity and interactions in the tumor microenvironment. Integrating single-cell RNA sequencing with other omics technologies revolutionizes the understanding of tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Fardeen Kabir Protick, Sadat Kamal Amit, Kshitij Amar, Shukantu Dev Nath, Rafee Akand, Virginia A. Davis, Sabrina Nilufar, Farhan Chowdhury
Summary: Polymerized polyacrylamide (PAA) substrates are widely used in mechanosensing studies due to their biocompatibility and functionalization capability. However, the cellular response on purely elastic substrates may not be physiologically relevant. This study utilized additive manufacturing to create viscoelastic PAA substrates and investigated cell mechanosensing on these substrates. The results showed that cell spreading can be decoupled from traction and prestress in physiologically relevant environments. The additively manufactured PAA substrates fill the void of lacking real tissue-like viscoelastic materials for mechanosensing studies.
Article
Cell Biology
Kshitij Amar, Sanjoy Saha, Avishek Debnath, Chun Hung Weng, Arpan Roy, Kyu Young Han, Farhan Chowdhury
Summary: Mechanoregulation of cell-ECM interactions is critical for pluripotent stem cell differentiation. Heterogeneity in response to differentiation cues can be attributed to variations in colony size and cell-ECM interactions. Biophysical regulation plays an important role in the heterogeneous differentiation of EpiSC colonies.
Review
Developmental Biology
Farhan Chowdhury, Bo Huang, Ning Wang
Summary: Forces and mechanics play a critical role in the physiology, pathology, and fate of stem cells, including embryonic stem cells, adult stem cells, and cancer stem cells. Understanding the impact of forces on cells and the pathways of mechanotransduction can contribute to the advancement of mechanomedicine.
CELLS & DEVELOPMENT
(2022)