- Home
- Publications
- Publication Search
- Publication Details
Title
Designing better enzymes: Insights from directed evolution
Authors
Keywords
-
Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 67, Issue -, Pages 212-218
Publisher
Elsevier BV
Online
2021-01-29
DOI
10.1016/j.sbi.2020.12.015
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Temperature, Dynamics, and Enzyme-Catalyzed Reaction Rates
- (2020) Vickery L. Arcus et al. Annual Review of Biophysics
- Enzymes with noncanonical amino acids
- (2020) Jingming Zhao et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Bottom-Up Nonempirical Approach To Reducing Search Space in Enzyme Design Guided by Catalytic Fields
- (2020) Wiktor Beker et al. Journal of Chemical Theory and Computation
- Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
- (2020) Kathy Y. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Directed Evolution of de novo Retro-Aldolases from QM/MM Studies
- (2020) Daria De Raffele et al. ACS Catalysis
- Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiency
- (2020) Hajo Kries et al. ACS Catalysis
- Harnessing Conformational Plasticity to Generate Designer Enzymes
- (2020) Rory M. Crean et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A mechanistic view of enzyme evolution
- (2020) Gloria Yang et al. PROTEIN SCIENCE
- Using nature’s blueprint to expand catalysis with Earth-abundant metals
- (2020) R. Morris Bullock et al. SCIENCE
- A defined structural unit enables de novo design of small-molecule–binding proteins
- (2020) Nicholas F. Polizzi et al. SCIENCE
- Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme
- (2019) H. Adrian Bunzel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Optimization of the Turnover in Artificial Enzymes via Directed Evolution Results in the Coupling of Protein Dynamics to Chemistry
- (2019) Joseph W. Schafer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Machine-learning-guided directed evolution for protein engineering
- (2019) Kevin K. Yang et al. NATURE METHODS
- A computational method for design of connected catalytic networks in proteins
- (2019) Brian D. Weitzner et al. PROTEIN SCIENCE
- Directed Evolution as a Probe of Rate Promoting Vibrations Introduced via Mutational Change
- (2018) Xi Chen et al. BIOCHEMISTRY
- Role of conformational dynamics in the evolution of novel enzyme function
- (2018) Miguel A. Maria-Solano et al. CHEMICAL COMMUNICATIONS
- Sampling molecular conformations and dynamics in a multiuser virtual reality framework
- (2018) Michael O’Connor et al. Science Advances
- The evolution of multiple active site configurations in a designed enzyme
- (2018) Nan-Sook Hong et al. Nature Communications
- Computational Design of Synthetic Enzymes
- (2018) Valerie Vaissier Welborn et al. CHEMICAL REVIEWS
- Solvent Entropy Contributions to Catalytic Activity in Designed and Optimized Kemp Eliminases
- (2017) Saurabh Belsare et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The Importance of the Scaffold for de Novo Enzymes: A Case Study with Kemp Eliminase
- (2017) Asmit Bhowmick et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase
- (2017) Cathleen Zeymer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Computational Optimization of Electric Fields for Improving Catalysis of a Designed Kemp Eliminase
- (2017) Valerie Vaissier et al. ACS Catalysis
- Exploring the Development of Ground-State Destabilization and Transition-State Stabilization in Two Directed Evolution Paths of Kemp Eliminases
- (2017) Garima Jindal et al. ACS Catalysis
- Role of Conformational Dynamics in the Evolution of Retro-Aldolase Activity
- (2017) Adrian Romero-Rivera et al. ACS Catalysis
- Rosetta:MSF: a modular framework for multi-state computational protein design
- (2017) Patrick Löffler et al. PLoS Computational Biology
- CADEE: Computer-Aided Directed Evolution of Enzymes
- (2017) Beat Anton Amrein et al. IUCrJ
- The coming of age of de novo protein design
- (2016) Po-Ssu Huang et al. NATURE
- Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase
- (2016) Richard Obexer et al. Nature Chemistry
- The role of side chain entropy and mutual information for improving the de novo design of Kemp eliminases KE07 and KE70
- (2016) Asmit Bhowmick et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity
- (2016) S. E. Boyken et al. SCIENCE
- The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
- (2015) Samuel Genheden et al. Expert Opinion on Drug Discovery
- Active Site Plasticity of a Computationally Designed Retro-Aldolase Enzyme
- (2014) Richard Obexer et al. ChemCatChem
- The role of reorganization energy in rational enzyme design
- (2014) Monika Fuxreiter et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Massive Thermal Acceleration of the Emergence of Primordial Chemistry, the Incidence of Spontaneous Mutation, and the Evolution of Enzymes
- (2014) Richard Wolfenden JOURNAL OF BIOLOGICAL CHEMISTRY
- Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
- (2014) N. Preiswerk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computational Enzyme Design
- (2013) Gert Kiss et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Optimization of reorganization energy drives evolution of the designed Kemp eliminase KE07
- (2013) A. Labas et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- De novo enzymes by computational design
- (2013) Hajo Kries et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design
- (2013) Sinisa Bjelic et al. JOURNAL OF MOLECULAR BIOLOGY
- Precision is essential for efficient catalysis in an evolved Kemp eliminase
- (2013) Rebecca Blomberg et al. NATURE
- Evolution of a designed retro-aldolase leads to complete active site remodeling
- (2013) Lars Giger et al. Nature Chemical Biology
- Iterative approach to computational enzyme design
- (2012) H. K. Privett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
- (2012) O. Khersonsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Robust design and optimization of retroaldol enzymes
- (2012) Eric A. Althoff et al. PROTEIN SCIENCE
- Challenges and Advances in Validating Enzyme Design Proposals: The Case of Kemp Eliminase Catalysis
- (2011) Maria P. Frushicheva et al. BIOCHEMISTRY
- Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution
- (2011) Olga Khersonsky et al. JOURNAL OF MOLECULAR BIOLOGY
- Origins of catalysis by computationally designed retroaldolase enzymes
- (2010) J. K. Lassila et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
- (2010) J. B. Siegel et al. SCIENCE
- Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series
- (2009) Olga Khersonsky et al. JOURNAL OF MOLECULAR BIOLOGY
- The Influence of Protein Dynamics on the Success of Computational Enzyme Design
- (2009) Jory Z. Ruscio et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
- (2009) Shina C. L. Kamerlin et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Kemp elimination catalysts by computational enzyme design
- (2008) Daniela Röthlisberger et al. NATURE
- De Novo Computational Design of Retro-Aldol Enzymes
- (2008) L. Jiang et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started