NAD + Repletion Reverses Heart Failure with Preserved Ejection Fraction

Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure

(2020) Michael Thomas Davidson et al.   CIRCULATION RESEARCH

Neuroprotective efficacy of P7C3 compounds in primate hippocampus

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Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3

(2018) Rebecca M. Parodi-Rullán et al.   Frontiers in Physiology

Epidemiology of heart failure with preserved ejection fraction

(2017) Shannon M. Dunlay et al.   Nature Reviews Cardiology

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

Post-translational modifications in mitochondria: protein signaling in the powerhouse

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Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Mitochondrion as a Target for Heart Failure Therapy　– Role of Protein Lysine Acetylation –

(2015) Chi Fung Lee et al.   CIRCULATION JOURNAL

SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

(2015) Yuxun Zhang et al.   PLoS One

Mouse SIRT3 Attenuates Hypertrophy-Related Lipid Accumulation in the Heart through the Deacetylation of LCAD

(2015) Tongshuai Chen et al.   PLoS One

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

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Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD + Synthesis in Cardiac Myocytes

(2009) Chiao-Po Hsu et al.   CIRCULATION RESEARCH

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

(2008) Andrey V Kuznetsov et al.   Nature Protocols