Article
Materials Science, Multidisciplinary
Tianhao Wang, Feixue Gao, Yan Zhang, Shaohua Wang, Xinjin Li, Zengdian Zhao, Yunhui Dong, Xiangye Li
Summary: A new ABA-typed azobenzene derivative (AD) was synthesized and utilized as a low-molecular-weight crosslinker to construct supramacromolecular hydrogels (SMHGs) with sodium alginate (SA) through electrostatic interactions. The concentration of AD had a significant influence on the moduli values of SMHGs. By utilizing the electrostatic interactions between AD and SA, as well as the interchain hydrogen bonds of SA, SMHGs exhibited sol-gel transitions under pH-, photo-, or thermo-stimuli. This work provides a simple and effective strategy for the construction of SMHGs using azobenzene derivatives as LMW crosslinkers.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sajjad Haider, Hafiz Abdul Mannan, Javed Hussain, Anarwul Hasan
Summary: Biopolymer-based composite hydrogels have shown great potential for tissue regeneration and antitumor applications, with excellent drug release properties and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Muhammad Suhail, Hamid Ullah, Quoc Lam Vu, Arshad Khan, Ming-Jun Tsai, Pao-Chu Wu
Summary: This study investigates pH-sensitive hydrogels based on biocompatible, biodegradable polysaccharides and natural polymers combined with synthetic monomers as controlled drug carriers. The hydrogel was characterized for its physical and chemical properties, surface morphology, crystallinity, swelling behavior, and drug release. The results showed that the hydrogel exhibited high crosslinking, drug loading capacity, and swelling behavior, making it suitable for controlled delivery of ketorolac tromethamine.
Article
Materials Science, Multidisciplinary
Daniel Massana Roquero, Paolo Bollella, Evgeny Katz, Artem Melman
Summary: The high porosity of calcium alginate hydrogels can be controlled by treatment with polyvinyl alcohol and cross-linking with diboronic acids, effectively blocking larger pores. This process reduces leaching of proteins trapped in the hydrogels by 20-30 fold, confirmed by microscopy techniques.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zunaira Huma Ghauri, Atif Islam, Muhammad Abdul Qadir, Abdul Ghaffar, Nafisa Gull, Maryam Azam, Azra Mehmood, Atif Ali Ghauri, Rafi Ullah Khan
Summary: The pH-sensitive hydrogels based on polyelectrolyte complex of chitosan/sodium alginate/PEG with 1,4-diaminobutane as a cross-linking agent were successfully prepared by solution casting method, exhibiting good hydrogel properties and drug release performance.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Physical
Mengze Lu, Fei Liu, Rui Tan, Zhenhua Xiao, Xue-hui Dong, Hui Wang, Liqun Tang, Tingjian Chen, Zi Liang Wu, Wei Hong, Taolin Sun
Summary: In this work, micro/nanoporous hydrogels with high mechanical strength are fabricated through the self-assembly of amphiphilic triblock copolymers. These hydrogels exhibit high permeability, tunable mechanical properties, and self-recovery behavior.
CHEMISTRY OF MATERIALS
(2022)
Article
Food Science & Technology
Oya Irmak Sahin, Kubra Uzuner, Ayse Neslihan Dundar, Mahmud Ekrem Parlak, Latife Betul Gul, Adnan Fatih Dagdelen, Furkan Turker Saricaoglu, Senay Simsek
Summary: Food gels are attractive for their biocompatibility, eco-friendly characteristics, and wide range of medical and food applications. This study examined the use of phycocyanin and honey embedded in a gel-type delivery system composed of alginate and gelatin. The results showed that higher alginate concentration increased the release of phenolic content, and the gel structure protected the phenolic content during digestion and enhanced their bio-accessibility. The study suggests that a combination of 1.5 g/100 mL alginate with gelatin can improve the functionality and bio-accessibility of functional ingredients without affecting sensory properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jiawei Huang, Linhong Chen, Ming Huang, Mingxian Liu
Summary: The application of nanotechnology in agrochemicals release can effectively reduce fertilizer usage and improve utilization. Urea was successfully intercalated into halloysite by solid-phase milling, and the maximum loading was 14.99 ± 1.33 wt%. Urea-Hal-sodium alginate hydrogel beads were fabricated by crosslinking, which showed good water retention and slow release properties. The release time of urea in the hydrogel was 60 times longer compared to pure urea. The hydrogel has a promising future in slow-release fertilizers for modern agriculture.
APPLIED CLAY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Cavallaro, Lorenzo Lisuzzo, Giuseppe Lazzara, Stefana Milioto
Summary: The design of hydrogels for controlled release of active species is challenging yet attractive. In this study, hybrid hydrogels composed of halloysite nanotubes and alginate were prepared, featuring a unique wire-like shape. The interaction between the morphology and dimensions of the hydrogel wires was found to significantly affect the release of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Muhammad Suhail, I-Hui Chiu, Yi-Ru Lai, Arshad Khan, Noorah Saleh Al-Sowayan, Hamid Ullah, Pao-Chu Wu
Summary: Smart and intelligent xanthan gum/pluronic F-127 hydrogels were developed for controlled delivery of atomoxetine HCl. Various parameters were evaluated to assess the properties of the hydrogel matrices including drug loading, porosity, swelling index, and drug release. The hydrogels demonstrated a pH-responsive nature with greater swelling and drug release at pH 7.4 compared to pH 1.2 and 4.6. The prepared hydrogel formulations followed first-order kinetics. The study suggests that these hydrogels have the potential to achieve extended release of atomoxetine HCl in the colon.
Article
Nanoscience & Nanotechnology
Anna Tverdokhlebova, Ilya Sterin, Costel C. Darie, Evgeny Katz, Oleh Smutok
Summary: This study investigated the electrochemically controlled release of proteins in a Ca2+-cross-linked alginate hydrogel deposited on an electrode surface. By applying different electrical potentials, the pH of the hydrogel could be modified, resulting in the shrinkage or swelling of the hydrogel film. The release of proteins was inhibited or activated depending on the pH changes. The release inhibition was effective with the application of +0.6 V, while the release activation was influenced by the protein size and charge. Cyclic application of oxidative and reductive potentials allowed for the repetitive change between inhibition and activation states. The alginate hydrogel film shrinking-swelling and protein release process were studied using a confocal fluorescent microscope.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Saman Zafar, Muhammad Hanif, Muhammad Azeem, Khalid Mahmood, Sonia Ashfaq Gondal
Summary: Hydrogels have become a promising candidate for drug delivery and tissue engineering systems due to their swellable and porous nature. Traditional toxic crosslinkers have poor water solubility and low biodegradation rate, leading to the development of new natural and synthetic crosslinking agents to improve mechanical properties. Novel non-toxic crosslinkers are being introduced to modulate release characteristics and achieve controlled drug release profiles for hydrogels made up of soluble and erodible polymers.
Article
Pharmacology & Pharmacy
Agathe Thouvenin, Balthazar Toussaint, Jelena Marinovic, Anne-Laure Gilles, Amelie Dufay Wojcicki, Vincent Boudy
Summary: This study designed a smart formulation of (S)-ketamine for buccal administration to improve absorption by increasing contact with mucosa components. Rheological and mucoadhesion tests were conducted to determine the optimal concentrations and components of the formulation. The study also found that batch-to-batch variability did not have a significant impact on drug release profile. This optimized formulation has fast release and potential clinical value, especially in emergencies.
Article
Chemistry, Physical
Daniel Massana Roquero, Brandon McCorduck, Paolo Bollella, Oleh Smutok, Artem Melman, Evgeny Katz
Summary: Alginate composite hydrogels with highly sensitive stimuli-responsive behavior were used for the signal-stimulated release of pre-loaded insulin. By controlling the release channels under the action of different Boolean logic gates, insulin could be released as needed. This method may play an important role in future medical diagnostics and treatments.
Article
Engineering, Biomedical
Chun-Chieh Huang, Miya Kang, Sajjad Shirazi, Yu Lu, Lyndon F. Cooper, Praveen Gajendrareddy, Sriram Ravindran
Summary: This study developed a method to encapsulate MSC-derived EVs in 3D hydrogels for prolonged delivery by leveraging interactions with ECM proteins, showing enhanced bone regeneration in in vivo models. The technology has the potential for controlled delivery of EVs in various regenerative medicine applications.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Krishan Kumar, Reddicherla Umapathi, Kalyan Ramesh, Seung-Kyu Hwang, Kwon Taek Lim, Yun Suk Huh, Pannuru Venkatesu
Summary: This study focused on thermoresponsive polymers synthesized using RAFT polymerization and investigated the influence of proteins on their phase behavior and aggregation. Various biophysical techniques were used to explore the interactions between the copolymer and proteins, revealing changes in LCST. The research provides insights into the interactions between heme proteins and block copolymers, which can guide the design of biomimetic surfaces and copolymer-protein bioconjugates.
Article
Chemistry, Physical
Sonyabapu Yadav, Kalyan Ramesh, Parveen Kumar, Sung-Han Jo, Seong Yoo, Yeong-Soon Gal, Sang-Hyug Park, Kwon Taek Lim
Summary: In this study, near-infrared (NIR)-responsive shell-crosslinked (SCL) micelles were successfully developed using the Diels-Alder (DA) click reaction. These SCL micelles effectively incorporated an anticancer drug and an NIR sensitizer, allowing for pH- and NIR-responsive drug release with burst release under NIR laser irradiation. The cytotoxicity analysis demonstrated non-toxicity against normal cells and significant antitumor activity towards cancer cells, suggesting their potential as a controlled drug delivery vehicle in cancer therapy.
Article
Chemistry, Multidisciplinary
Daru Seto Bagus Anugrah, Laura Virdy Darmalim, Permono Adi Putro, Liana Dewi Nuratikah, Nurwarrohman Andre Sasongko, Parsaoran Siahaan, Adi Yulandi
Summary: This study used density functional theory (DFT) method to investigate the interaction between Poly(styrene-maleic acid) (PSMA) and water molecules. The results showed a high hydrogen bond interaction between PSMA and water, with increasing strength as the number of water molecules increased. This indicates that water molecules are easily transported and retained within the PSMA matrix.
INDONESIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Raynardthan Pontoh, Vania Edita Rarisavitri, Christine Charen Yang, Maximilliam Febriand Putra, Daru Seto Bagus Anugrah
Summary: The molecular interactions between amylum and cellulose were investigated computationally, revealing weak to medium intermolecular bonds between them.
INDONESIAN JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Kalyan Ramesh, Sonyabapu Yadav, Avnish Kumar Mishra, Sung-Han Jo, Sang-Hyug Park, ChulWoong Oh, Kwon Taek Lim
Summary: In this study, near-infrared-responsive interface cross-linked micelles were developed using the Diels-Alder click reaction. These micelles showed pH and NIR-responsive drug release, providing a promising drug delivery system for cancer treatment.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Dwi Hudiyanti, Sherllyn Meida Christa, Nur Hanna Mardhiyyah, Daru Seto Bagus Anugrah, Tatik Widiarih, Parsaoran Siahaan
Summary: This paper provides dynamic insight into the aggregation profile of systems containing six different phospholipid species, cholesterol, and vitamin C. The simulation results show that cholesterol influences the formation of liposomes and the encapsulation of vitamin C in the liposome structure.
Article
Polymer Science
Rianita Pramitasari, Levina Natasha Gunawicahya, Daru Seto Bagus Anugrah
Summary: The incorporation of red dragon fruit peel anthocyanin into cassava starch and chitosan films as a color indicator has shown potential for smart packaging materials. The indicator film is sensitive to pH and can monitor food freshness by changing color. It also has improved antioxidant activity and flexibility.
Article
Pharmacology & Pharmacy
D. Hudiyanti, V. N. R. Putri, Y. Hikmahwati, S. M. Christa, P. Siahaan, D. S. B. Anugrah
Summary: This study investigates the interaction within a liposome-based drug delivery system using computer simulation. The results confirm that phospholipids, cholesterol, beta-carotene, and vitamin C in the liposome structures interact through noncovalent interactions. These interactions do not cause chemical changes to the encapsulated drug or other molecules. The formed noncovalent interactions include moderate-strength hydrogen bonds and van der Waals interactions.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Manufacturing
Daru Seto Bagus Anugrah, Graciela Delarosa, Pricylia Wangker, Rianita Pramitasari, Dionysius Subali
Summary: A novel indicator film was developed using N-glutaryl chitosan as a matrix and butterfly pea flower anthocyanin as a dye. The film showed higher sensitivity to pH changes, a more compact structure, and stronger hydrophilic properties compared to films without glutaryl modification. It exhibited antioxidant and antimicrobial activity, biodegradability, UV-Vis light barrier properties, and was non-toxic to cells. Furthermore, the film demonstrated potential as a smart packaging solution for monitoring the freshness of chicken breast.
PACKAGING TECHNOLOGY AND SCIENCE
(2023)
Article
Multidisciplinary Sciences
Christian Kenneth, Daru Seto Bagus Anugrah, Jeffry Julianus, Sendy Junedi
Summary: Computational methods were used to investigate the antidiabetic activity of six anthocyanidins by inhibiting GKRP activity. The geometry and quantum chemical properties of anthocyanidins were optimized using density functional theory. Molecular docking and molecular dynamics studies showed that pelargonidin is a potential GKRP inhibitor with high binding affinity and the ability to maintain GKRP in an inactive conformation through the inhibition of GK binding. Key residues controlling the binding of F1P to GKRP and anthocyanidin to GKRP-F1P were also identified. Pelargonidin derived from anthocyanidins has the most potential as a GKRP inhibitor and antidiabetic nutraceutical.
Article
Polymer Science
Valentia Rossely Santoso, Rianita Pramitasari, Daru Seto Bagus Anugrah
Summary: This study aims to develop and characterize indicator films incorporated with red dragon fruit peel anthocyanins and gambier catechins to detect banana ripeness. The results show that the film incorporated with anthocyanins and catechins in a ratio of 1:40 (w/w) resulted in better color stability, mechanical properties, light and water vapor barrier ability, and antioxidant activity. The application of the indicator films to banana packaging resulted in a change in color on the third day of storage, indicating their potential use as an indicator to monitor banana ripeness.
Article
Polymer Science
Daru Seto Bagus Anugrah, Laura Virdy Darmalim, Muhammad Rifky Irwanto Polanen, Permono Adi Putro, Nurwarrohman Andre Sasongko, Parsaoran Siahaan, Zeno Rizqi Ramadhan
Summary: This paper uses computational analysis to study the interactions between alginate dimers and water molecules. The results show that both alginate and sodium alginate molecules form hydrogen bonds and Van der Walls interactions with water molecules, and there is also a metal-nonmetal bond between sodium alginate and water molecules. The computational data demonstrate that the interactions between alginate dimers and water molecules contribute to the stability of the complex structure.
Article
Polymer Science
Niraj Kumar Vishwakarma, Vijay Kumar Patel, Payel Mitra, K. Ramesh, Kheyanath Mitra, Sambhav Vishwakarma, Krishnendu Acharya, Nira Misra, Pralay Maiti, Biswajit Ray
Summary: The study successfully synthesized double hydrophilic ABA-type amphiphilic polyurethane-based triblock copolymers using a combination of polymerization techniques. The properties of the copolymers vary, with the critical micelle concentration of PNVP-b-PU-b-PNVP increasing with the length of the PNVP block, and the lower critical solution temperature of PNIPAM-b-PU-b-PNIPAM being 23.5 and 25.5 degrees Celsius, respectively.
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
