Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer

Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1B effect on fatty acid metabolism in Bladder Cancer

(2019) Venkatrao Vantaku et al.   CLINICAL CANCER RESEARCH

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

(2019) Choh Yeung et al.   CANCER RESEARCH

Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

(2019) Venkatrao Vantaku et al.   ONCOGENE

Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase

(2019) Hoshie Iriki et al.   PLoS One

Inhibition of LDHA Deliver Potential Anticancer Performance in Renal Cell Carcinoma

(2016) Xinsheng Wang et al.   UROLOGIA INTERNATIONALIS

Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression

(2016) Chia-Chi Chang et al.   Oncotarget

High-throughput hyperpolarized 13 C metabolic investigations using a multi-channel acquisition system

(2015) Jaehyuk Lee et al.   JOURNAL OF MAGNETIC RESONANCE

Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model

(2015) V. C. Sandulache et al.   MOLECULAR CANCER THERAPEUTICS

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)

(2015) NIANSHUANG LI et al.   ONCOLOGY REPORTS

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a*

(2015) Xiaoli Wu et al.   Oncotarget

Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy

(2014) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

(2014) Luigi Fiume et al.   Future Medicinal Chemistry

Comprehensive review on lactate metabolism in human health

(2014) M. Adeva-Andany et al.   MITOCHONDRION

Evaluation of Hyperpolarized [1-13C]-Pyruvate by Magnetic Resonance to Detect Ionizing Radiation Effects in Real Time

(2014) Vlad C. Sandulache et al.   PLoS One

Doxycycline Alters Metabolism and Proliferation of Human Cell Lines

(2013) Ethan Ahler et al.   PLoS One

Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

(2013) Yefei Rong et al.   TUMOR BIOLOGY

Increased LDH5 expression is associated with lymph node metastasis and outcome in oral squamous cell carcinoma

(2012) Martin Grimm et al.   CLINICAL & EXPERIMENTAL METASTASIS

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

Glycolytic Inhibition Alters Anaplastic Thyroid Carcinoma Tumor Metabolism and Improves Response to Conventional Chemotherapy and Radiation

(2012) Vlad C. Sandulache et al.   MOLECULAR CANCER THERAPEUTICS

Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

(2011) Vlad C. Sandulache et al.   CANCER

LKB1/AMPK/mTOR signaling pathway in hematological malignancies: From metabolism to cancer cell biology

(2011) Alexa S. Green et al.   CELL CYCLE

Disruptive TP53 Mutation Is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer

(2011) D. Sano et al.   CLINICAL CANCER RESEARCH

Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy

(2011) M. I. Koukourakis et al.   CLINICAL CANCER RESEARCH

mTOR links oncogenic signaling to tumor cell metabolism

(2011) Jessica L. Yecies et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials

(2010) C. Granchi et al.   CURRENT MEDICINAL CHEMISTRY

Glucose metabolism in cancer cells

(2010) Alessandro Annibaldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

(2009) H. Xie et al.   MOLECULAR CANCER THERAPEUTICS

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypoxia-Inducible Factor (HIF-1α) Pathway, Angiogenic Factors Production and Poor Prognosis

(2008) Yanislav Kolev et al.   ANNALS OF SURGICAL ONCOLOGY

An Orthotopic Model of Papillary Thyroid Carcinoma in Athymic Nude Mice

(2008) Soon-Hyun Ahn et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL