Article
Infectious Diseases
Jose Raul Nieto-Saucedo, Luis Esau Lopez-Jacome, Rafael Franco-Cendejas, Claudia Adriana Colin-Castro, Melissa Hernandez-Duran, Luis Raul Rivera-Garay, Karina Senyase Zamarripa-Martinez, Juan Luis Mosqueda-Gomez
Summary: The prevalence of carbapenem-resistant Gram-negative bacilli (CR-GNB) and the frequency of carbapenemase-encoding genes were evaluated in a tertiary referral center in El Bajio, Mexico. Among 508 Gram-negative bacilli, 37 were carbapenem-resistant (7.3%), and only 15 (40.5%) of them carried carbapenemase-encoding genes.
Article
Microbiology
Farooq Ahmed Wani, Altaf Bandy, Mohammed Jayed S. Alenzi, Abdulaziz Ibrahim Alzarea, Abdullah S. Alanazi, Mohammed Ubaidullah Sayeed, Ashokkumar Thirunavukkarasu, Bilal Tantry, Mushtaq Dar
Summary: Intensive care units are complex environments that favor high resistance in microorganisms, particularly Gram-negative bacteria. This study found that a majority of infections in intensive care patients are caused by multidrug-resistant Gram-negative bacteria, with high resistance rates observed for third- and fourth-generation cephalosporins, carbapenems, and fluoroquinolones. Amikacin was identified as the most effective antibiotic, highlighting the need for enhanced surveillance and antimicrobial stewardship programs.
Article
Infectious Diseases
Pietro Picconi, Charlotte K. Hind, J. Mark Sutton, Khondaker Miraz Rahman
Summary: Finding new antibiotic classes against multidrug-resistant bacteria is urgently needed. Pyrrolobenzodiazepines (PBDs) with a C8-linked aliphatic-heterocycle have recently been identified as a new broad-spectrum antibiotic class with activity against Gram-negative bacteria. By replacing the active imine moiety of lead PBD compounds with amide, non-DNA binding and noncytotoxic dilactam analogues were obtained to improve the safety potential of this class.
Article
Chemistry, Multidisciplinary
Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu
Summary: This study developed virus-inspired nanodrugs for high-efficiency antibiotic delivery and enhanced antibacterial effects, demonstrating their potential application in antibacterial treatment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemical Research Methods
Martina Traykovska, Robert Penchovsky
Summary: In recent decades, antibiotic drug resistance has become a significant challenge in modern medicine due to the emergence of bacteria strains resistant to known antibiotics. Riboswitches have emerged as novel targets for antibacterial drug discovery. This study describes the design and applications of antisense oligonucleotides as antibacterial agents targeting riboswitches, demonstrating their suitability for drug development.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Infectious Diseases
Qi Zhang, Shang Chen, Xiaojia Liu, Wenhan Lin, Kui Zhu
Summary: The combination of marine antibiotic equisetin and colistin shows a strong synergistic effect against Gram-negative bacteria, especially multi-drug resistant strains. Colistin promotes the intracellular accumulation of equisetin, leading to quick bacteria killing. Equisetin also restores colistin activity in an infection model, providing an alternative approach to combat Gram-negative pathogens in clinics.
Review
Engineering, Environmental
Meera Varghese, Manoj Balachandran
Summary: CDs, known for their nontoxic characteristics and inherent antibacterial potency, have gained significant attention as potential alternative antibiotics due to the increasing antibiotic resistance of bacterial strains. The light-driven antibacterial action of CDs is safe and effective with minimal side effects, and their direct interaction with bacterial cells contributes to their overall antibacterial activity. The unique and complex mechanisms of antibacterial activity of CDs involve ROS generation, degeneration of cell structure, and cytoplasm leakage, among other factors, providing insights for significant future research in this area.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Microbiology
Inga V. Leus, Justyna Adamiak, Brinda Chandar, Vincent Bonifay, Shibin Zhao, Scott S. Walker, Brian Squadroni, Carl J. Balibar, Nihar Kinarivala, Lisa C. Standke, Henning U. Voss, Derek S. Tan, Valentin V. Rybenkov, Helen I. Zgurskaya
Summary: Gram-negative bacteria are more resistant to antibiotics due to their outer membrane and efflux pumps. Different Gram-negative pathogens have different permeability barriers and mechanisms for antibiotics penetration. Two methods, comparing antibacterial activities and measuring intracellular concentrations, are used to analyze the effect of permeability barriers on antibiotics. However, there is no quantitative agreement between these assays. The three pathogens analyzed in this study, Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii, have different permeability barriers, with the outer membrane playing a dominant role in E. coli and P. aeruginosa, while efflux dominates in A. baumannii. Additionally, compounds of the same chemotype may use different permeation pathways depending on small chemical modifications.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Thitiya Yungyuen, Tanittha Chatsuwan, Rongpong Plongla, Sakawrat Kanthawong, Umaporn Yordpratum, Supayang P. Voravuthikunchai, Sarunyou Chusri, Dennapa Saeloh, Worada Samosornsuk, Nuntra Suwantarat, Romanee Chaiwarith, Surat Wannalerdsakun, Porpon Rotjanapan, Prawat Chantharit, Orawan Tulyaprawat, Iyarit Thaipisuttikul, Pattarachai Kiratisin
Summary: The study found a serious situation of drug resistance among Gram-negative bacilli in Thailand, including important resistant strains like E. coli, K. pneumoniae, and A. baumannii. It highlights the urgent need for strict control measures to address this issue.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jinane Tabcheh, Julia Vergalli, Anne Davin-Regli, Noha Ghanem, Jean-Marie Pages, Charbel Al-Bayssari, Jean Michel Brunel
Summary: Antibiotic resistance is increasing morbidity and mortality for non-curable infectious diseases. Novel strategies, such as effective antibiotic combinations and antibiotics with non-antibiotic activity-enhancing compounds, have emerged to combat multidrug-resistant microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Albebson L. Lim, Bailey W. Miller, Zhenjian Lin, Mark A. Fisher, Louis R. Barrows, Margo G. Haygood, Eric W. Schmidt
Summary: Turnercyclamycin A and B exhibit Gram-negative bacteria-specific toxicity, remaining active against colistin resistant clinical isolates. Turnercyclamycin A shows lower resistance compared to Turnercyclamycin B. The unique resistance profile and potential promise in treating drug-resistant infections make Turnercyclamycins a valuable compound class.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Sreeja K. Vamsi, Rama S. Moorthy, Mary N. Hemiliamma, Rama B. Chandra Reddy, Deepak J. Chanderakant, Shravani Sirikonda
Summary: This study aimed to identify carbapenemase producing Gram-negative bacteria (GNB) using phenotypic methods and confirm the presence of resistant genes using real-time PCR. The results showed a significant percentage of GNBs resistant to carbapenems, with the most common carbapenemase genes being NDM and the co-existence of NDM with VIM. The study highlights the importance of routine carbapenem resistance testing and the potential for the spread of highly antibiotic-resistant genes.
SAUDI MEDICAL JOURNAL
(2022)
Article
Infectious Diseases
Estefania Cano-Martin, Ines Portillo-Calderon, Patricia Perez-Palacios, Jose Maria Navarro-Mari, Maria Amelia Fernandez-Sierra, Jose Gutierrez-Fernandez
Summary: Antibiotic resistance in bacteria has been challenging to control, particularly in the case of multidrug-resistant bacteria such as carbapenemase-producing bacteria. A study conducted in a hospital in Southern Spain between 2015 and 2020 revealed an increasing trend in infections with carbapenemase-producing bacteria. The combination of epidemiological data with real-time molecular sequencing techniques can significantly advance the transmission control of these bacteria and the management of infected patients.
Review
Chemistry, Medicinal
Qidi Kong, Yushe Yang
Summary: Antimicrobial resistance poses a global challenge as the effectiveness of old antibiotics diminishes. Discovery and development of antibacterial agents have been accelerated to replenish the limited and shrinking arsenal of antibiotics. Significant advances have been made in recent years in the antibacterial field, including new compounds of known classes and new compounds with new mechanisms.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Microbiology
Jingyuan Xi, Peiyao Jia, Ying Zhu, Wei Yu, Jingjia Zhang, Haotian Gao, Wei Kang, Ge Zhang, Jin Li, Tong Wang, Yingchun Xu, Qiwen Yang
Summary: The study in China revealed that the main pathogens of Gram-negative bacteria bloodstream infections were Enterobacteriaceae, with Escherichia coli being the most common pathogen. Klebsiella pneumonia, Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacter cloacae showed high resistance rates to multiple antibiotics. Polymyxin B and colistin have become crucial agents in combating infections caused by multidrug-resistant Gram-negative bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
