Article
Immunology
Qing Ye, Mei Wu, Chao Zhou, Xishan Lu, Baoying Huang, Ning Zhang, Hui Zhao, Hang Chi, Xiaojing Zhang, Dandan Ling, Rong-Rong Zhang, Zhuofan Li, Dan Luo, Yi-Jiao Huang, Hong-Ying Qiu, Haifeng Song, Wenjie Tan, Ke Xu, Bo Ying, Cheng-Feng Qin
Summary: This study developed a combined vaccine against COVID-19 and influenza, using the LNP-mRNA vaccine platform, and successfully protected mice from coinfection with SARS-CoV-2 and influenza.
Article
Multidisciplinary Sciences
So Young Kim, Joo-Hee Kim, Miyoung Kim, Jee Hye Wee, Younghee Jung, Chanyang Min, Dae Myoung Yoo, Songyong Sim, Hyo Geun Choi
Summary: The study found that prior influenza/URI histories were associated with increased susceptibility and morbidity of COVID-19 patients, but not with mortality.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Zu-Li Zhang, Yu-Lei Hou, De-Tao Li, Feng-Zeng Li
Summary: The detection of anti-SARS-CoV-2 IgG and IgM showed high diagnostic efficiency in assisting the diagnosis of SARS-CoV-2 infection, with gold immunochromatography assay potentially being the preferred method.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Hossam Waleed Almadhoon, Aboalmagd Hamdallah, Sarah Makram Elsayed, Abdulrahman Ibrahim Hagrass, Mohammed Tarek Hasan, Aya Mamdouh Fayoud, Mohammed Al-Kafarna, Mohammad Elbahnasawy, Fadel Alqatati, Khaled Mohamed Ragab, Mohamed Sayed Zaazouee, Elfatih A. Hasabo
Summary: Recent evidence suggests that influenza vaccination may reduce the clinical outcomes of COVID-19. The study found a significant reduction in the risk of mechanical ventilation for COVID-19 patients who received the influenza vaccine. However, there were no statistically significant differences in mortality rate, hospital admissions, and intensive care admissions between vaccinated and non-vaccinated groups. Further research is encouraged due to limitations in the data and the regular updates of the influenza vaccine.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Alessandra Ruggiero, Chiara Piubelli, Lucia Calciano, Simone Accordini, Maria Teresa Valenti, Luca Dalle Carbonare, Gabriel Siracusano, Nigel Temperton, Natalia Tiberti, Silvia Stefania Longoni, Massimo Pizzato, Silvia Accordini, Tobia Fantoni, Lucia Lopalco, Alberto Beretta, Zeno Bisof, Donato Zipeto, Donato A.M.S.L.V group
Summary: A longitudinal study was conducted on healthcare workers who received the BNT162b2 vaccine to quantify anti-SARS-CoV-2 IgG and IgM levels. It was found that coordinated expression of IgG-S and IgM-S after vaccination was associated with a more efficient response in both antibody levels and virus-neutralizing activity. The unconventional responses may suggest a recruitment of cross coronaviruses immunity by vaccination, warranting further investigation.
Article
Medicine, Research & Experimental
John J. L. Jacobs
Summary: COVID-19 is a serious disease that has infected more than 40 million people, with long COVID possibly being caused by persistent systemic infection.
MEDICAL HYPOTHESES
(2021)
Article
Immunology
Kieran Dee, Daniel M. Goldfarb, Joanne Haney, Julien A. R. Amat, Vanessa Herder, Meredith Stewart, Agnieszka M. Szemiel, Marc Baguelin, Pablo R. Murcia
Summary: Research suggests that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication, thus reducing the number of coronavirus disease 2019 cases. This virus-virus interaction can have population-wide effects.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ryohei Hirose, Hiroshi Ikegaya, Yuji Naito, Naoto Watanabe, Takuma Yoshida, Risa Bandou, Tomo Daidoji, Yoshito Itoh, Takaaki Nakaya
Summary: The study found that SARS-CoV-2 survives longer on human skin compared to influenza A virus, increasing the risk of contact transmission and accelerating the pandemic. Proper hand hygiene is crucial in preventing the spread of the virus. Ethanol can completely inactivate both viruses within 15 seconds on human skin.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Daniel Toribio-Avedillo, Clara Gomez-Gomez, Laura Sala-Comorera, Lorena Rodriguez-Rubio, Albert Carcereny, David Garcia-Pedemonte, Rosa Maria Pinto, Susana Guix, Belen Galofre, Albert Bosch, Susana Merino, Maite Muniesa
Summary: Wastewater-based surveillance is a valuable tool for monitoring viral circulation and serving as an early warning system. This study conducted a 15-month weekly sampling campaign in two wastewater treatment plants in Barcelona, Spain, and found the presence of SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) in wastewater. The data obtained from wastewater surveillance provided new information on the abundance of respiratory viruses in the Barcelona area and correlated favorably with clinical data.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Junhao Luo, Zhuohan Zhang, Song Zhao, Rongbao Gao
Summary: Influenza virus and coronavirus are two common emerging pathogens that cause respiratory tract infections in humans. The emergence of a novel coronavirus SARS-CoV-2 in December 2019 has caused the global pandemic COVID-19, which has persisted for almost three years. Studies have shown similarities in transmission and pathogenesis between influenza and COVID-19, and vaccination and antiviral drugs have positive roles in prevention and control. Understanding the etiology, pathogenesis, vaccine and antiviral drug development for these diseases is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Erica Normandin, Melissa Rudy, Nikolaos Barkas, Stephen F. Schaffner, Zoe Levine, Robert F. Padera, Mehrtash Babadi, Shibani S. Mukerji, Daniel J. Park, Bronwyn L. MacInnis, Katherine J. Siddle, Pardis C. Sabeti, Isaac H. Solomon
Summary: By analyzing tissue samples from fatal COVID-19 cases, we found that viral RNA is present in extrapulmonary tissues, and the viral variants identified in different tissues are mostly unique. Patients with a longer disease course had more high-frequency minor variants, including a tissuespecific high-frequency variant in the spike protein. These findings suggest the presence of adaptation and/or compartmentalized infection, providing insights into extrapulmonary COVID-19 symptoms and the potential for viral reservoirs.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Antonio Di Sabatino
Summary: IgM memory B cells may play a protective role against COVID-19 and other coronaviruses in the acute phase of infection, but further research is needed. Early detection of impaired IgM memory B cell response in patients can improve care and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
David M. Morens, Jeffery K. Taubenberger, Anthony S. Fauci
Summary: Despite being caused by different viruses, the influenza pandemic of 1918 and the COVID-19 pandemic of 2019-2021 share similarities in clinical, pathological, and epidemiological features, as well as in responses from civic, public health, and medical sectors. By comparing and contrasting the two pandemics, we have learned valuable lessons over the span of a century and are applying them to the challenges posed by COVID-19.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Surgery
Mingqian Li, Shifei Song, Guangyao Tian, Yao Zhi, Yuguo Chen, Heyu Huang, Wenyu Jiao, Ying Yu, Guoyue Lv
Summary: Graft-versus-host disease (GVHD) following liver transplantation is a common complication, and this study found a correlation between the occurrence of GVHD and the presence of donor T cells in the blood. Longitudinal tracking of GVH T cell clones revealed clonal expansion before disease onset. Additionally, the study found that levels of inflammatory cytokines and TCR repertoire diversity may be potential independent risk factors for GVHD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Gastroenterology & Hepatology
Chao Jiang, Xiao-Dong Sun, Wei Qiu, Yu-Guo Chen, Da-Wei Sun, Guo-Yue Lv
Summary: Conversion therapy is an effective strategy to downstage hepatocellular carcinoma (HCC) and increase the chances of liver transplantation (LT). Combining various treatment modalities, including targeted drugs and immunotherapy, has shown promising results in shrinking tumors and benefiting advanced-stage HCC patients. Further research and investigation are needed to fully realize the potential of conversion treatment strategies.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Review
Engineering, Biomedical
Shu-xuan Li, Lanlan Chen, Ming-qian Li, Guo-yue Lv
Summary: This study provides a systematic review on pharmacological therapies for liver defatting, with a focus on defatting agents that can be clinically employed in ex-vivo translational paradigm of liver normothermic machine perfusion (NMP). The study suggests that NMP can be used as a platform for organ treatment in combination with defatting agents.
Article
Gastroenterology & Hepatology
Lanlan Chen, Zhongqi Fan, Xiaodong Sun, Wei Qiu, Wentao Mu, Kaiyuan Chai, Yannan Cao, Guangyi Wang, Guoyue Lv
Summary: Based on population-based genetic data, this study found inverse associations between diet-derived antioxidants and nonalcoholic fatty liver disease (NAFLD), as well as positive associations between selenium and lycopene levels and NAFLD risk. Furthermore, genetically predicted levels of carotene and retinol were inversely associated with the risk of type 2 diabetes (T2D).
HEPATOLOGY INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Lanlan Chen, Zhongqi Fan, Yuexuan Zhao, Hongqun Yang, Guoyue Lv
JOURNAL OF HEPATOLOGY
(2023)
Article
Virology
Wenying Gao, Zhaolong Li, Qingtian Guan, Wenzhe Cui, Baishong Zheng, Qiang Ding, Guoyue Lv, Jiancheng Xu, Wenyan Zhang
Summary: This study analyzed the genomic characteristics of the SARS-CoV-2 outbreak in Jilin Province, China, from December 2020 to February 2021. The clinical isolates belonged to the B.1 lineage and several dominant linear B cell epitopes were identified. The convalescent sera from SARS-CoV-2 infected patients showed neutralizing activity against four widely spreading SARS-CoV-2 variants, but with significant differences in neutralizing activities against different variants.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Yao Zhi, Mingqian Li, Guoyue Lv
Summary: T cells play an important role in allograft rejection, but the heterogeneity of T cells and the limitations of traditional detection approaches have hindered our understanding of their fate in recipients. Recent developments in single-cell techniques have allowed for the identification and characterization of T cells at a single-cell resolution, providing deeper insights into their heterogeneity. Comprehensive understanding can be achieved through joint analysis, and multi-omics techniques have been used to characterize T cells in health and disease, including transplantation. This review focuses on the application and challenges of these technologies in studying alloreactive T cells, aiming to improve our understanding of T cell heterogeneity in solid organ transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Kou, Shuxuan Li, Wei Qiu, Zhongqi Fan, Mingqian Li, Guoyue Lv
Summary: Hepatic stellate cells (HSCs) upregulate hypoxia inducible factor 1 alpha (HIF-1 alpha) expression in response to fibrosis-induced hypoxia. Increased expression of alpha-SMA, HIF-1 alpha, and IL-6 was observed in liver fibrotic tissues, along with their colocalization. HIF-1 alpha induced IL-6 secretion in activated HSCs by binding to the HRE region in the IL6 promoter. HIF-1 alpha also promoted IL-17A expression and secretion in HSCs, mediated by IL-17A-enriched supernatant.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Lanlan Chen, Zhongqi Fan, Xiaodong Sun, Wei Qiu, Wentao Mu, Kaiyuan Chai, Yannan Cao, Guangyi Wang, Guoyue Lv
Summary: Cholecystectomy may not increase the risk of colorectal cancer, but it might increase the risk of irritable bowel syndrome.
CHINESE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Hongchen Zhang, Lanlan Chen, Zhongqi Fan, Guoyue Lv
Summary: Observational studies have shown a higher incidence of primary biliary cholangitis (PBC) in patients with inflammatory bowel disease (IBD) compared to healthy individuals. This study used genetic data from genome-wide association studies (GWAS) to investigate the causal relationship between IBD and PBC. The results suggest that genetically predicted IBD increases the risk of PBC, but genetic susceptibility to PBC does not alter the risk of IBD. This has important implications for understanding the etiology of PBC and managing patients with IBD.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Shifei Song, Yao Zhi, Guangyao Tian, Xiaodong Sun, Yuguo Chen, Wei Qiu, Wenyu Jiao, Heyu Huang, Ying Yu, Mingqian Li, Guoyue Lv
Summary: This study found that patients who experience acute rejection (AR) after liver transplant have a higher proportion of immature CD56(bright)CD16(-) subset and a lower cytolytic CD56(dim)CD16(+) subset in their blood-circulating NK cells. The NKp30-positive ratio in the CD56(dim)CD16(+) subset showed the most prominent predictive ability for AR. Additionally, the blood-circulating NK cells in rejectors maintained a higher CD56(bright)CD16(-) and lower CD56(dim)CD16(+) composition, along with increased expressions of NKp30 and NKp46, throughout the first year after transplant.
LIVER TRANSPLANTATION
(2023)
Letter
Oncology
Jia-Hao Xu, Guang-Zhao Shao, Yi-Fan Yang, Zhong-Qi Fan, Guo-Yue Lv, Tian Yang
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Ting Li, Xiaodong Sun, Zheng Hu, Guoyue Lv
Summary: This study suggests that C3H mice are better recipients for MOLT compared to B6J mice, and donor strains and stent materials play important roles in the long-term survival of MOLT. An ideal long-term survival of MOLT can be achieved by a rational donor-recipient-stent combination.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Gastroenterology & Hepatology
Lanlan Chen, Wei Qiu, Xiaodong Sun, Menghan Gao, Yuexuan Zhao, Mingyue Li, Zhongqi Fan, Guoyue Lv
Summary: Serum levels of LDL-C and HDL-C are inversely associated with the risk of cholelithiasis in a linear manner. However, the relationship between serum TC and cholelithiasis risk is non-linear, with lower TC being associated with higher risk, and serum TG has an inverted "U-shaped" relationship with cholelithiasis risk. MR analyses suggest that lower TC and higher TG levels are independent causal risk factors. Drug-target MR analysis indicates that inhibition of HMGCR can reduce the risk of cholelithiasis, which is supported by colocalisation analysis.
Article
Gastroenterology & Hepatology
Lanlan Chen, Yuexuan Zhao, Mingyue Li, Guoyue Lv
Summary: This study used proteome-wide Mendelian randomization to identify 14 proteins positively associated with an increased risk of PSC and 8 proteins inversely associated with PSC risk. Colocalization analysis indicated that AIF1 and HLA-DQA2 were shared proteins with PSC and should be direct targets for PSC.
HEPATOLOGY INTERNATIONAL
(2023)