Review
Clinical Neurology
Lei Sun, Wei Shan, Huajun Yang, Ru Liu, Jianping Wu, Qun Wang
Summary: Post-traumatic epilepsy is a serious consequence of traumatic brain injury, and inflammation plays a significant role in epileptogenesis. Understanding the contribution of neuroinflammation to the development of PTE is crucial, requiring further research.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Matthew Pease, Jonathan Elmer, Ameneh Zare Shahabadi, Arka N. Mallela, Juan F. Ruiz-Rodriguez, Daniel Sexton, Niravkumar Barot, Jorge A. Gonzalez-Martinez, Lori Shutter, David O. Okonkwo, James F. Castellano
Summary: By analyzing early electroencephalographic (EEG) features, it is possible to identify patients at high risk for posttraumatic epilepsy (PTE) in severe traumatic brain injury (TBI) cases. Quantitative EEG (qEEG) analysis showed that PTE patients had higher spectral power and power variance in the delta frequencies, as well as higher peak envelope. These findings have significant implications for early clinical management and patient selection in clinical trials.
Article
Biochemistry & Molecular Biology
Jie Wang, Xiaoyang Chai, Fang Zhang, Yuchen Li, Huijun Shen, Keyi Lu
Summary: The reduced level of neuronal autophagy during the latency period may be a possible mechanism for the increased susceptibility to post-traumatic epilepsy (PTE) after mild traumatic brain injury (mTBI). The study used a rat model to simulate mTBI and observed the extent of injury and the incidence of epilepsy. The results showed that the incidence of PTE was higher after mTBI, and the level of autophagy was reduced during the latency period. Administration of the autophagy agonist rapamycin significantly reduced the incidence of PTE.
NEUROCHEMICAL RESEARCH
(2023)
Article
Clinical Neurology
Juho Laaksonen, Ville Ponkilainen, Ilari Kuitunen, Julius Mottonen, Ville M. Mattila
Summary: pTBI increases the risk of posttraumatic epilepsy for many years after the initial trauma. Children who undergo operative management for pTBI have a high risk for developing epilepsy, especially within the first 4 years after the injury.
Article
Neurosciences
Chase M. Carver, Haley R. DeWitt, Aiola P. Stoja, Mark S. Shapiro
Summary: The study demonstrated an upregulation of TRPC1, TRPC4, and TRPC5 in the hippocampus and cortex following TBI, leading to neuronal hyperexcitability and increased susceptibility to seizures. The time-dependent changes in TRPC4/TRPC5-containing channels altered cholinergic responses and neuronal activity, contributing to proexcitatory sensitization.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Kasper Lolk, Theis Lange, Felix Elwert, Julie W. W. Dreier, Jakob Christensen
Summary: Traumatic brain injury (TBI) and stroke are well-known causes of acquired epilepsy, and TBI is also a risk factor for stroke. This study investigated the extent to which the effect of TBI on epilepsy operated through intermediary stroke. The results showed that less than 6% of the risk of epilepsy following TBI is mediated by stroke, but this mechanism becomes more significant with age and for late onset epilepsies.
Article
Biochemistry & Molecular Biology
Rie Komori, Taira Matsuo, Aya Yokota-Nakatsuma, Ritsuka Hashimoto, Shizuka Kubo, Chihiro Kozawa, Tomomi Kono, Yasuhiro Ishihara, Kouichi Itoh
Summary: Levetiracetam suppresses neuroinflammation and prevents epilepsy onset by inhibiting the expression of Fosl1, which regulates astrocyte reactivity during epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Frederick P. Mariajoseph, Zhibin Chen, Praba Sekhar, Sarah S. Rewell, Terence J. O'Brien, Ana Antonic-Baker, Bridgette D. Semple
Summary: This study conducted a systematic review to determine the incidence of posttraumatic epilepsy (PTE) and associated risk factors in pediatric traumatic brain injury (TBI) patients. The overall incidence of PTE following pediatric TBI was found to be 10%, with early seizures, severe TBI, and intracranial hemorrhage identified as risk factors.
Review
Clinical Neurology
Chris G. Dulla, Asla Pitkanen
Summary: Traumatic brain injury (TBI) can lead to post-traumatic epilepsy (PTE) which often resists standard anti-seizure drugs. Novel treatment strategies are needed to prevent PTE after TBI, as there are no successful approaches currently available. TBI presents a unique opportunity for intervention to prevent epileptogenesis, with potential for exciting new advances in the field.
Article
Biochemistry & Molecular Biology
Ying Wang, Pedro Andrade, Asla Pitkaenen
Summary: The study found that peripheral infection after TBI increases seizure susceptibility and neuronal activation in the perilesional cortex and bilaterally in the dentate gyrus, particularly in animals with prolonged perilesional T2 enhancement. This suggests that treatment of infections and reduction of post-injury neuro-inflammation are important components in preventing epileptogenesis after TBI.
Article
Clinical Neurology
Yilun Chen, Songlu Li, Wendong Ge, Jin Jing, Hsin Yi Chen, Daniel Doherty, Alison Herman, Safa Kaleem, Kan Ding, Gamaleldin Osman, Christa B. Swisher, Christine Smith, Carolina B. Maciel, Ayham Alkhachroum, Jong Woo Lee, Monica B. Dhakar, Emily J. Gilmore, Adithya Sivaraju, Lawrence J. Hirsch, Sacit B. Omay, Hal Blumenfeld, Kevin N. Sheth, Aaron F. Struck, Brian L. Edlow, M. Brandon Westover, Jennifer A. Kim
Summary: This study evaluated the contribution of quantitative electroencephalograms in predicting post-traumatic epilepsy (PTE) and found that these features enhance the predictive value of PTE1, especially when combined with TBI mechanism and CT abnormalities. Future research should validate these findings.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Zachary L. Hickman, Lisa A. Spielman, Ernest J. Barthelemy, Tanvir F. Choudhri, Brittany Engelman, Al O. Giwa, Jacob D. Greisman, Konstantinos Margetis, Meaghan Race, Jueria Rahman, D. Roxanne Todor, Spyridoula Tsetsou, Jamie S. Ullman, Prashin Unadkat, Kristen Dams-O'Connor
Summary: This study is the first to identify factors influencing clinical decision making in antiseizure medication (ASM) prophylaxis after complicated mild traumatic brain injury (cmTBI). The results reveal a striking diversity in ASM use in cmTBI, highlighting the need for prospective controlled studies to inform standardized guidelines.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Xavier Ekolle Ndode-Ekane, Riikka Immonen, Elina Hamalainen, Eppu Manninen, Pedro Andrade, Robert Ciszek, Tomi Paananen, Olli Grohn, Asla Pitkanen
Summary: Adjusting electrode coordinates based on MRI can increase the accuracy of intracerebral electrode placement and improve the interpretation of EEG-recorded signals in rats with TBI-induced brain atrophy.
Article
Health Care Sciences & Services
Xueping Wang, Jie Zhong, Ting Lei, Deng Chen, Haijiao Wang, Lina Zhu, Shanshan Chu, Ling Liu
Summary: This study successfully predicted the risk of posttraumatic epilepsy (PTE) using an artificial neural network (ANN) model, demonstrating its superiority in prediction compared to traditional statistical methods.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Neurosciences
Lin Li, Udaya Kumar, Jing You, Yufeng Zhou, Shennan A. Weiss, Jerome Engel, Anatol Bragin
Summary: In this study, the role of high-frequency oscillations (HFO) in epileptogenesis following traumatic brain injury (TBI) was investigated in rats. Results showed that fast ripple (FR) rates can serve as a biomarker for network formation and predict the development of epilepsy, allowing for early prediction of post-TBI epilepsy risk in patients.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Critical Care Medicine
Lacey W. Heinsberg, Annie I. Arockiaraj, Elizabeth A. Crago, Dianxu Ren, John R. Shaffer, Paula R. Sherwood, Susan M. Sereika, Daniel E. Weeks, Yvette P. Conley
NEUROCRITICAL CARE
(2020)
Article
Oncology
Maura K. McCall, Mary Connolly, Bethany Nugent, Yvette P. Conley, Catherine M. Bender, Margaret Q. Rosenzweig
JOURNAL OF CANCER EDUCATION
(2020)
Article
Oncology
Komal Singh, Kord M. Kober, Steven M. Paul, Marilyn Hammer, Fay Wright, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
SUPPORTIVE CARE IN CANCER
(2020)
Article
Public, Environmental & Occupational Health
Hsing-Hua S. Lin, Ashley Naimi, Maria M. Brooks, Gale A. Richardson, Jessica G. Burke, Joyce T. Bromberger
ANNALS OF EPIDEMIOLOGY
(2020)
Article
Oncology
Fay Wright, Kord M. Kober, Bruce A. Cooper, Steven M. Paul, Yvette P. Conley, Marilyn Hammer, Jon D. Levine, Christine Miaskowski
SUPPORTIVE CARE IN CANCER
(2020)
Article
Nursing
Kaleigh Mellett, Dianxu Ren, Sheila Alexander, Nicole Osier, Sue R. Beers, David O. Okonkwo, Ava M. Puccio, Yvette P. Conley
BIOLOGICAL RESEARCH FOR NURSING
(2020)
Article
Statistics & Probability
Yingda Jiang, Chi-Yang Chiu, Qi Yan, Wei Chen, Michael B. Gorin, Yvette P. Conley, M'hamed Lajmi Lakhal-Chaieb, Richard J. Cook, Christopher Amos, Alexander F. Wilson, Joan E. Bailey-Wilson, Francis J. McMahon, Ana Vazquez, Ao Yuan, Xiaogang Zhong, Momiao Xiong, Daniel E. Weeks, Ruzong Fan
Summary: Genetics plays a significant role in age-related macular degeneration (AMD) and the study utilized a new generalized functional linear mixed model (GFLMM) to test for gene-based association in AMD families. Significant associations were found with known AMD genes CFH and ARMS2, while suggestive signals were observed in genes like ASAH1, CLEC6A, TMEM63C, and SGSM1. The GFLMM-based statistics provided a new tool for conducting family-based genetic studies of complex diseases.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2021)
Article
Nursing
Komal Singh, Huangshen Cao, Christine Miaskowski, Yvette P. Conley, Marilyn Hammer, Fay Wright, Jon D. Levine, Kord M. Kober
Summary: This study aimed to evaluate perturbed biological pathways associated with endocytosis and apoptosis in oncology patients, and found that inflammation of the GI mucosa induced by chemotherapy may lead to initiation of endocytotic and apoptotic processes in the gut, which are associated with the occurrence of chemotherapy-induced nausea.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Article
Oncology
Rafael Diaz, Kord M. Kober, Carol Viele, Bruce A. Cooper, Steven M. Paul, Marilyn Hammer, Fay Wright, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: Chemotherapy-induced diarrhea (CID) is a common symptom that occurs in 50 to 80% of patients. This study identified four distinct diarrhea profiles among 1133 patients: none (58.3%), decreasing (22.0%), increasing (5.2%), and high (14.5%). Patients in the high class had lower functional status, worse comorbidity profile, were more likely to have gastrointestinal cancer, and receive chemotherapy on a 14-day cycle compared to the none class.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nursing
Monica A. Wagner, Susan W. Wesmiller, Meaghan Maydick, Lisa M. Gawron, Frances M. Peterson-Burch, Yvette P. Conley
Summary: Integrating omics into non-pharmacological intervention research helps understand response variability and discover genes associated with intervention effectiveness. This study found nine genes related to response, indicating potential targets for future investigations using omic approaches in non-pharmacological interventions.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Article
Cardiac & Cardiovascular Systems
Alexis Nasr, Karen A. Matthews, Maria M. Brooks, Emma Barinas-Mitchell, Trevor Orchard, Jeff Billheimer, Norman C. Wang, Dan McConnell, Daniel J. Rader, Samar R. El Khoudary
Summary: This study assessed the relationship between Life's Simple 7 (LS7) score and health behavior components with future HDL function and metrics in midlife women. The results showed that a higher LS7 score was associated with favorable HDL profile, particularly in relation to ideal body mass index. These findings contribute to a better understanding of the role of HDL in cardiovascular health.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Oncology
Mei R. Fu, Bradley E. Aouizerat, Gary Yu, Yvette Conley, Deborah Axelrod, Amber A. Guth, Jean-Pierre Gagner, Jeanna M. Qiu, David Zagzag
Summary: The study aimed to identify lymphedema symptom patterns and their association with phenotypic characteristics and biomarkers using latent class analysis (LCA). Three distinct lymphedema symptom classes were identified at 8 weeks and 12 months post-surgery, with participants more likely to be in the severe symptom classes at 12 months post-surgery if they had specific phenotypic characteristics and biomarker levels. Pre-surgery levels of IL1-a, IL-6, IL-8, and VEGF were associated with the severe symptom class at 8 weeks post-surgery, suggesting predictive value for lymphedema symptoms.
CURRENT BREAST CANCER REPORTS
(2021)
Article
Oncology
Kate R. Oppegaard, Laura B. Dunn, Kord M. Kober, Lynda Mackin, Marilyn J. Hammer, Yvette P. Conley, Jon David Levine, Christine Miaskowski
ONCOLOGY NURSING FORUM
(2020)
Article
Neurosciences
Kord M. Kober, Man-Cheung Lee, Adam Olshen, Yvette P. Conley, Marina Sirota, Michael Keiser, Marilyn J. Hammer, Gary Abrams, Mark Schumacher, Jon D. Levine, Christine Miaskowski
Review
Nursing
Mei R. Fu, Emma Kurnat-Thoma, Angela Starkweather, Wendy A. Henderson, Ann K. Cashion, Janet K. Williams, Maria C. Katapodi, Karin Reuter-Rice, Kathleen T. Hickey, Veronica Barcelona de Mendoza, Kathleen Calzone, Yvette P. Conley, Cindy M. Anderson, Debra E. Lyon, Michael T. Weaver, Pamela K. Shiao, Rose E. Constantino, Shu-Fen Wung, Marilyn J. Hammer, Joachim G. Voss, Bernice Coleman
INTERNATIONAL JOURNAL OF NURSING SCIENCES
(2020)