Engineering microorganisms for the biosynthesis of dicarboxylic acids

Fumarate production with Rhizopus oryzae: utilising the Crabtree effect to minimise ethanol by-product formation

(2020) Reuben M. Swart et al.   Biotechnology for Biofuels

Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate

(2020) Ryosuke Fujiwara et al.   Nature Communications

Engineering glucose metabolism for enhanced muconic acid production in Pseudomonas putida KT2440

(2020) Gayle J. Bentley et al.   METABOLIC ENGINEERING

Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase

(2020) Jung Ho Ahn et al.   Nature Communications

Improved Production of Malic Acid in Aspergillus niger by Abolishing Citric Acid Accumulation and Enhancing Glycolytic Flux

(2020) Yongxue Xu et al.   ACS Synthetic Biology

Engineering the transmission efficiency of the noncyclic glyoxylate pathway for fumarate production in Escherichia coli

(2020) Xiulai Chen et al.   Biotechnology for Biofuels

Formation and functionalization of membraneless compartments in Escherichia coli

(2020) Shao-Peng Wei et al.   Nature Chemical Biology

Glutaric acid production by systems metabolic engineering of an l-lysine–overproducingCorynebacterium glutamicum

(2020) Taehee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic engineering of microorganisms for production of aromatic compounds

(2019) Damla Huccetogullari et al.   Microbial Cell Factories

Metabolic engineering for the production of dicarboxylic acids and diamines

(2019) Tong Un Chae et al.   METABOLIC ENGINEERING

Microbial production of glycolate from acetate by metabolically engineered Escherichia coli

(2019) Wei Li et al.   JOURNAL OF BIOTECHNOLOGY

Citric acid and itaconic acid accumulation: variations of the same story?

(2019) Levente Karaffa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Morphology engineering of Aspergillus oryzae for l ‐malate production

(2019) Xiulai Chen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production

(2019) Wenna Li et al.   Nature Communications

Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger

(2019) Abeer H. Hossain et al.   Biotechnology for Biofuels

Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae

(2019) Behrooz Darbani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Cre-loxP-based genetic system in Aspergillus niger ATCC1015 and its application to construction of efficient organic acid-producing cell factories

(2019) Yongxue Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Integrated strain- and process design enable production of 220 g L−1 itaconic acid with Ustilago maydis

(2019) Hamed Hosseinpour Tehrani et al.   Biotechnology for Biofuels

Construction of an energy-conserving glycerol utilization pathways for improving anaerobic succinate production in Escherichia coli

(2019) Yong Yu et al.   METABOLIC ENGINEERING

Enhancing succinic acid productivity in the yeast Yarrowia lipolytica with improved glycerol uptake rate

(2019) Khai Lun Ong et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Rerouting carbon flux for optimized biosynthesis of mesaconate in Escherichia coli

(2018) Jingyu Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a non-phosphotransferase system for cis,cis -muconic acid production in Corynebacterium glutamicum

(2018) Woo-Shik Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhancement of malate production through engineering of the periplasmic rTCA pathway in Escherichia coli

(2018) Liang Guo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of adaptive laboratory evolution to overcome a flux limitation in an Escherichia coli production strain

(2018) Kento Tokuyama et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of EayjjPB encoding a dicarboxylate transporter important for succinate production under aerobic and anaerobic conditions in Enterobacter aerogenes

(2018) Keita Fukui et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Engineering synergetic CO 2 -fixing pathways for malate production

(2018) Guipeng Hu et al.   METABOLIC ENGINEERING

Microbial production of branched-chain dicarboxylate 2-methylsuccinic acid via enoate reductase-mediated bioreduction

(2018) Jian Wang et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for the production of L-malate from xylose

(2018) Zheng-Jun Li et al.   METABOLIC ENGINEERING

Engineering the production of dipicolinic acid in E. coli

(2018) Maria K. McClintock et al.   METABOLIC ENGINEERING

Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate

(2018) Manman Zhang et al.   Nature Communications

An Orthogonal and pH-Tunable Sensor-Selector for Muconic Acid Biosynthesis in Yeast

(2018) Tim Snoek et al.   ACS Synthetic Biology

Manufacturing Multienzymatic Complex Reactors In Vivo by Self-Assembly To Improve the Biosynthesis of Itaconic Acid in Escherichia coli

(2018) Zhongwei Yang et al.   ACS Synthetic Biology

Development of a Plasmid-Free Biosynthetic Pathway for Enhanced Muconic Acid Production in Pseudomonas chlororaphis HT66

(2018) Songwei Wang et al.   ACS Synthetic Biology

An Engineered Aro1 Protein Degradation Approach for Increased cis,cis-Muconic Acid Biosynthesis in Saccharomyces cerevisiae

(2018) Michael E. Pyne et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineering Escherichia coli for Glutarate Production as the C5 Platform Backbone

(2018) Mei Zhao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A bio-based route to the carbon-5 chemical glutaric acid and to bionylon-6,5 using metabolically engineered Corynebacterium glutamicum

(2018) Christina Maria Rohles et al.   GREEN CHEMISTRY

Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical

(2018) Hee Taek Kim et al.   METABOLIC ENGINEERING

Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis

(2018) Yaping Yang et al.   Nature Communications

Metabolic Engineering of Escherichia coli for Efficient Production of 2-Pyrone-4,6-dicarboxylic Acid from Glucose

(2018) Zi Wei Luo et al.   ACS Synthetic Biology

Spatial modulation and cofactor engineering of key pathway enzymes for fumarate production in Candida glabrata

(2018) Xiulai Chen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of the thermophilic filamentous fungus Myceliophthora thermophila to produce fumaric acid

(2018) Shuying Gu et al.   Biotechnology for Biofuels

Corynebacterium glutamicum CgynfM encodes a dicarboxylate transporter applicable to succinate production

(2018) Keita Fukui et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate

(2018) Sebastian Knorr et al.   Nature Communications

Muconic Acid Production Using Gene-Level Fusion Proteins in Escherichia coli

(2018) Ryosuke Fujiwara et al.   ACS Synthetic Biology

Metabolic Engineering of Escherichia coli for High Yield Production of Succinic Acid Driven by Methanol

(2018) Wenming Zhang et al.   ACS Synthetic Biology

Efficient Production of the Dicarboxylic Acid Glutarate by Corynebacterium glutamicum via a Novel Synthetic Pathway

(2018) Fernando Pérez-García et al.   Frontiers in Microbiology

Rewiring the reductive tricarboxylic acid pathway and L-malate transport pathway of Aspergillus oryzae for overproduction of L-malate

(2017) Jingjing Liu et al.   JOURNAL OF BIOTECHNOLOGY

Production of Odd-Carbon Dicarboxylic Acids in Escherichia coli Using an Engineered Biotin–Fatty Acid Biosynthetic Pathway

(2017) Robert W. Haushalter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microbial synthesis of medium-chain chemicals from renewables

(2017) Stephen Sarria et al.   NATURE BIOTECHNOLOGY

Enhanced production of C5 dicarboxylic acids by aerobic-anaerobic shift in fermentation of engineered Escherichia coli

(2017) Jia-Le Yu et al.   PROCESS BIOCHEMISTRY

Engineering a synthetic pathway for maleate in Escherichia coli

(2017) Shuhei Noda et al.   Nature Communications

Muconic Acid Production via Alternative Pathways and a Synthetic “Metabolic Funnel”

(2017) Brian Thompson et al.   ACS Synthetic Biology

De Novo Biosynthesis of Glutarate via α-Keto Acid Carbon Chain Extension and Decarboxylation Pathway in Escherichia coli

(2017) Jian Wang et al.   ACS Synthetic Biology

Combinatorial optimization of CO2transport and fixation to improve succinate production by promoter engineering

(2016) Jun-Han Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhanced malic acid production from glycerol with high-cell density Ustilago trichophora TZ1 cultivations

(2016) Thiemo Zambanini et al.   Biotechnology for Biofuels

Robust succinic acid production from crude glycerol using engineered Yarrowia lipolytica

(2016) Cuijuan Gao et al.   Biotechnology for Biofuels

Production of succinic acid by metabolically engineered microorganisms

(2016) Jung Ho Ahn et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering nonphosphorylative metabolism to synthesize mesaconate from lignocellulosic sugars in Escherichia coli

(2016) Wenqin Bai et al.   METABOLIC ENGINEERING

Metabolic design of a platform Escherichia coli strain producing various chorismate derivatives

(2016) Shuhei Noda et al.   METABOLIC ENGINEERING

Model-based metabolic engineering enables high yield itaconic acid production by Escherichia coli

(2016) Björn-Johannes Harder et al.   METABOLIC ENGINEERING

Metabolic engineering of Corynebacterium glutamicum for shikimate overproduction by growth-arrested cell reaction

(2016) Takahisa Kogure et al.   METABOLIC ENGINEERING

Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions

(2016) Seokjung Cheong et al.   NATURE BIOTECHNOLOGY

High-level production of ethylmalonyl-CoA pathway-derived dicarboxylic acids by Methylobacterium extorquens under cobalt-deficient conditions and by polyhydroxybutyrate negative strains

(2015) Frank Sonntag et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis

(2015) Yoshihiro Toya et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Production of mesaconate in Escherichia coli by engineered glutamate mutase pathway

(2015) Jingyu Wang et al.   METABOLIC ENGINEERING

EngineeringEscherichia colicoculture systems for the production of biochemical products

(2015) Haoran Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Escherichia coli for Conversion of Glucose to Medium-Chain ω-Hydroxy Fatty Acids and α,ω-Dicarboxylic Acids

(2015) Christopher H. Bowen et al.   ACS Synthetic Biology

Ustilago maydisproduces itaconic acid via the unusual intermediatetrans-aconitate

(2015) Elena Geiser et al.   Microbial Biotechnology

Influence of the pH on the itaconic acid production with Aspergillus terreus

(2014) Antje Hevekerl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Increased dipicolinic acid production with an enhancedspoVFoperon inBacillus subtilisand medium optimization

(2014) Fumikazu Takahashi et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Biological Production of Muconic Acid via a Prokaryotic 2,3-Dihydroxybenzoic Acid Decarboxylase

(2014) Xinxiao Sun et al.   ChemSusChem

Metabolic engineering of carbon and redox flow in the production of small organic acids

(2014) Chandresh Thakker et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Extending shikimate pathway for the production of muconic acid and its precursor salicylic acid in Escherichia coli

(2014) Yuheng Lin et al.   METABOLIC ENGINEERING

Expression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger

(2014) Laura van der Straat et al.   Microbial Cell Factories

A Novel Muconic Acid Biosynthesis Approach by Shunting Tryptophan Biosynthesis via Anthranilate

(2013) Xinxiao Sun et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Activating C4-dicarboxylate transporters DcuB and DcuC for improving succinate production

(2013) Jing Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of l-malic acid

(2013) Stephen H. Brown et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering ofEscherichia colifor the production of fumaric acid

(2013) Chan Woo Song et al.   BIOTECHNOLOGY AND BIOENGINEERING

Influence of carbon and nitrogen concentration on itaconic acid production by the smut fungusUstilago maydis

(2013) Nicole Maassen et al.   ENGINEERING IN LIFE SCIENCES

Metabolic engineering of muconic acid production in Saccharomyces cerevisiae

(2012) Kathleen A. Curran et al.   METABOLIC ENGINEERING

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

(2011) Judith Becker et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

(2011) Harry Yim et al.   Nature Chemical Biology