Blood retinal barrier and ocular pharmacokinetics: Considerations for the development of oncology drugs

Further considerations towards an effective and efficient oncology drug discovery DMPK strategy

(2020) Beth Williamson et al.   CURRENT DRUG METABOLISM

The clearance of dead cells by efferocytosis

(2020) Emilio Boada-Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy

(2020) Charles Pottier et al.   Cancers

The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina

(2020) Ayako Sayama et al.   TOXICOLOGIC PATHOLOGY

Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency

(2020) Deborah S. Lew et al.   Frontiers in Immunology

Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies in rabbits

(2020) David Bussing et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration

(2019) Naoto Mori et al.   PLoS One

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

(2019) Nicola Colclough et al.   DRUG DISCOVERY TODAY

Physiologically based ocular pharmacokinetic modeling using computational methods

(2019) Paul J. Missel et al.   DRUG DISCOVERY TODAY

Tight Junctions of the Outer Blood Retina Barrier

(2019) Aisling Naylor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent advances in drug and nutrient transport across the blood-retinal barrier

(2018) Yoshiyuki Kubo et al.   Expert Opinion on Drug Metabolism & Toxicology

Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells

(2018) Anna-Kaisa Rimpelä et al.   JOURNAL OF CONTROLLED RELEASE

Kinase-targeted cancer therapies: progress, challenges and future directions

(2018) Khushwant S. Bhullar et al.   Molecular Cancer

Imaging techniques to study drug transporter function in vivo

(2018) Nicolas Tournier et al.   PHARMACOLOGY & THERAPEUTICS

UNC569-induced Morphological Changes in Pigment Epithelia and Photoreceptor Cells in the Retina through MerTK Inhibition in Mice

(2018) Ayako Sayama et al.   TOXICOLOGIC PATHOLOGY

Models and approaches describing metabolism, transport, and toxicity of drugs administered by the ocular route

(2018) Jennifer L Dumouchel et al.   DRUG METABOLISM AND DISPOSITION

Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs

(2018) Paulina Jakubiak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of MERTK promotes suppression of tumor growth in BRAF mutant and BRAF wild-type melanoma

(2018) Lenka Sinik et al.   MOLECULAR CANCER THERAPEUTICS

Inner Blood–Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig

(2017) Zhengyu Zhang et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetic aspects of retinal drug delivery

(2017) Eva M. del Amo et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Ocular toxicities associated with targeted anticancer agents: an analysis of clinical data with management suggestions

(2017) Chen Fu et al.   Oncotarget

The Emerging Role of Targeted Therapy and Immunotherapy in the Management of Brain Metastases in Non-Small Cell Lung Cancer

(2017) Annick Wong   Frontiers in Oncology

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium

(2016) Grazyna Palczewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Activity of Alectinib in Advanced RET -Rearranged Non–Small Cell Lung Cancer

(2016) Jessica J. Lin et al.   Journal of Thoracic Oncology

Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Computed Tomography Imaging

(2016) Anna-Kaisa Rimpelä et al.   MOLECULAR PHARMACEUTICS

A comprehensive insight on ocular pharmacokinetics

(2016) Vibhuti Agrahari et al.   Drug Delivery and Translational Research

Methods for culturing retinal pigment epithelial cells: a review of current protocols and future recommendations

(2016) Aaron H Fronk et al.   Journal of Tissue Engineering

MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors

(2015) Shameka J. Shelby et al.   EXPERIMENTAL EYE RESEARCH

Optic Neuropathy and Blindness Associated With Crizotinib for Non–Small-Cell Lung Cancer With EML4-ALK Translocation

(2015) Stephen G. Chun et al.   JOURNAL OF CLINICAL ONCOLOGY

Volume of Distribution in Drug Design

(2015) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prediction of Ocular Drug Distribution from Systemic Blood Circulation

(2015) Kati-Sisko Vellonen et al.   MOLECULAR PHARMACEUTICS

Crizotinib-Induced Abnormal Signal Processing in the Retina

(2015) Toshiyuki Ishii et al.   PLoS One

Characteristics of structures and lesions of the eye in laboratory animals used in toxicity studies

(2015) Kazumoto Shibuya et al.   Journal of Toxicologic Pathology

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

(2013) Seng Chuan Tang et al.   INTERNATIONAL JOURNAL OF CANCER

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

(2012) S. Betty Yan et al.   INVESTIGATIONAL NEW DRUGS

Ocular Toxicity of Targeted Therapies

(2012) Daniel J. Renouf et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

(2012) Jing Liu et al.   ACS Medicinal Chemistry Letters

CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib

(2011) Daniel B. Costa et al.   JOURNAL OF CLINICAL ONCOLOGY

Lipophilicity and Transporter Influence on Blood-Retinal Barrier Permeability: A Comparison with Blood-Brain Barrier Permeability

(2010) Ken-ichi Hosoya et al.   PHARMACEUTICAL RESEARCH

Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development

(2009) Jenny C. Geatrell et al.   EXPERIMENTAL EYE RESEARCH