Article
Chemistry, Medicinal
Laura Catalina Velez-Vargas, Gloria A. Santa-Gonzalez, Diego Uribe, Isabel C. Henao-Castaneda, Johanna Pedroza-Diaz
Summary: This study investigates the biological effects of chlorogenic acid (CGA) on colorectal cancer cells and its interactions with beta-catenin and LRP6. It was found that CGA significantly affects cell viability and DNA fragmentation in SW480 cells but not in HT-29 cells. However, it induces ROS production in both cell lines. Additionally, CGA shows high affinity for beta-catenin sites and similar interactions with LRP6. These findings suggest a possible modulatory role of CGA in the Wnt/beta-catenin pathway of colorectal cancer.
Article
Oncology
Qi Sun, Boxin Liu, Quanxue Lan, Zijie Su, Qiuxia Fu, Lian Wang, Yingying Deng, Chuanli Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guowu Yang, Desheng Lu
Summary: The study revealed that chloroxylenol could inhibit the Wnt/beta-catenin signaling pathway, leading to anti-tumor effects in colorectal cancer cells, including inhibition of proliferation and migration, induction of apoptosis, and suppression of stemness.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yue Chen, LvYuwei Tang, Xinrong Ye, Yimeng Chen, Enfang Shan, Hongyu Han, Caiyun Zhong
Summary: This study reveals for the first time the interaction between ZO-1 and beta-catenin in colorectal cancer stem cells. ZO-1 can inhibit sphere formation and expression of CSC markers, thus attenuating the progression of colorectal cancer.
Article
Oncology
Yanhui Si, Lei Li, Weiwei Zhang, Qiling Liu, Baochi Liu
Summary: The study found that GANT61 effectively eliminates cancer cells and CSCs in colorectal cancer by blocking the Wnt/beta-catenin and Notch signaling pathways.
Editorial Material
Oncology
David C. Montrose, Lorenzo Galluzzi
Summary: Restoring ketogenesis in the colorectal cancer microenvironment can decrease the synthesis of CXCL12 by cancer-associated fibroblasts, thus enhancing tumor infiltration by immune effector cells and improving the efficacy of immune checkpoint inhibitors.
Article
Biochemistry & Molecular Biology
Mohammad Sadegh Taghizadeh, Ali Niazi, Ali Moghadam, Ali Reza Afsharifar
Summary: The study demonstrates that bioactive peptides isolated from Achillea eriophora have potential as a cancer treatment, showing anti-proliferative effects on MCF-7 cancer cells and DPPH radical scavenging and cupric-ion reducing activities. SEM analysis revealed that the peptides kill cancer cells by creating pores in the membrane.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
Jian Wang, Lun Zhang, Hui Xin, Ya Guo, Baokang Zhu, Liqian Su, Shanshan Wang, Jiali Zeng, Qingru Chen, Rui Deng, Ziyan Wang, Jie Wang, Xiaobao Jin, Shuiqing Gui, Yinghua Xu, Xuemei Lu
Summary: An orally administered colon-accumulating mitochondria-targeted drug delivery nanoplatform (M27-39@FA-MCNs) was synthesized using a small peptide (M27-39) and folic acid-modified mesoporous carbon nanoparticles (FA-MCNs). M27-39@FA-MCNs increased the targeting ability of M27-39 towards mitochondria and the colon, and increased the accumulation and residence time of M27-39 in colon tumors. Oral administration of M27-39@FA-MCNs alleviated colorectal cancer (CRC) by targeting tumor cell mitochondria, interfering with mitochondrial energy metabolism, and activating the P53/Caspase-3 mitochondrial pathway.
ACTA BIOMATERIALIA
(2022)
Article
Cell Biology
Huifang Zhu, Zijie Su, Jiong Ning, Liang Zhou, Lifeng Tan, Sapna Sayed, Jiaxing Song, Zhongyuan Wang, Huan Li, Qi Sun, Shanshan Liu, Ou Sha, Feng Leng, Xianxiong Chen, Desheng Lu
Summary: TMEM97 upregulation is associated with poor outcome in multiple human cancers, including breast cancer, by enhancing LRP6-mediated Wnt signaling. TMEM97 interacts with LRP6 to promote CK1 delta/epsilon-dependent phosphorylation of LRP6, leading to stabilization of beta-catenin. In breast cancer cells, TMEM97 deficiency attenuated Wnt/beta-catenin signaling and suppressed tumorigenic properties, suggesting that targeting TMEM97 could be a promising therapeutic strategy for breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Article
Pharmacology & Pharmacy
Di Pan, Wen Zhang, Nenling Zhang, Yini Xu, Yi Chen, Jianqing Peng, Yan Chen, Yanyan Zhang, Xiangchun Shen
Summary: In this study, the synergistic effects of the combination treatment with Oxymatrine (OMT) and Doxorubicin (DOX) on colorectal cancer cells were investigated, showing significant inhibition of tumor growth and migration, as well as enhanced apoptosis through ROS generation. The combination therapy also reduced cardiotoxicity and involved molecular alterations of specific proteins, suggesting a potential therapeutic strategy for CRC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
John M. Macharia, Ruth W. Mwangi, Nora Rozmann, Kaposztas Zsolt, Timea Varjas, Paschal O. Uchechukwu, Isabel N. Wagara, Bence L. Raposa
Summary: The development and identification of molecular compounds that can kill or inhibit transformed cells promoting carcinogenesis without toxic effects on normal cells are extremely important. This study conducted a systematic review and evaluated pharmacotherapeutic biomolecules active against colon cancer carcinogenesis. The research found that natural antioxidants in certain plants have inhibitory effects on the occurrence and progression of colon cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Weijia Zhang, Chang Peng, Xue Shen, Yuemei Yuan, Wei Zhang, Chunjuan Yang, Meicun Yao
Summary: Colorectal cancer (CRC) is a common cancer worldwide, with 5-fluorouracil (5-FU) being the main chemotherapeutic agent. However, drug resistance to 5-FU is becoming a challenge, and natural products like Sanguisorba officinalis L. are being explored for potential solutions. The triterpenoid compound AGE extracted from this herb showed strong anti-CRC effects by inducing apoptosis, autophagy, and cell cycle arrest through the Wnt signaling pathway.
Article
Biology
Akemi Shishido, Masaaki Miyo, Kazuki Oishi, Natsumi Nishiyama, Meiqiao Wu, Hiroyuki Yamamoto, Shihori Kouda, Xin Wu, Satoshi Shibata, Yuhki Yokoyama, Hirofumi Yamamoto
Summary: High expression of LRP6 is associated with malignancy in solid tumors, but its role in colorectal cancer with constitutive activation of Wnt signaling is not well understood. We compared the expression and function of LRP6 in CRC and ESCC with different Wnt signaling mutations. We found high expression of LRP6 and beta-catenin in both CRC and ESCC, but LRP6 knockdown only affected Wnt signaling activity in ESCC cell lines without Wnt signaling mutations. This suggests that LRP6 function may depend on constitutive activation of the Wnt signaling pathway.
Review
Microbiology
Christina Thoda, Maria Touraki
Summary: Colorectal cancer (CRC) is a global disease with high morbidity and mortality rates. Drug resistance and side effects of chemotherapy have led to the need for alternative anticancer agents, such as probiotic-derived bioactive compounds. These compounds, including bacteriocins, short-chain fatty acids, and bacterial peptides, exhibit anti-inflammatory and antiproliferative properties. This review summarizes the classification and biological role of postbiotics, as well as their interaction with the gut microbiota and their potential for CRC prevention and treatment.
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xi Zhao, Xiaoqiang Qi, Wenrui Lian, Xin Tong, Hua Wang, Liya Su, Ping Wei, Zhuochen Zhuang, Jianhua Gong, Liping Bai
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Microbiology
Yu Jiang, Mengxin Geng, Liping Bai
Article
Immunology
Weiwei Guo, Fengying Xu, Zhuochen Zhuang, Zhe Liu, Jiming Xie, Liping Bai
Summary: The novel exopolysaccharide Ebosin shows promising anti-inflammatory effects in a psoriasis-like model, regulating inflammation through multiple pathways and enhancing the percentage of regulatory T cells, while reducing the number of inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu Chen, Zhuochen Zhuang, Jing Yang, Liping Bai
Summary: The study focuses on the pathogenesis of cytokine release syndrome (CRS) caused by COVID-19, revealing that Trichomicin has inhibitory effects on cytokine expression both in vitro and in vivo. The research findings demonstrate that Trichomicin significantly improves the survival rate of mice stimulated with LPS, providing a foundation for further research on microbial natural products' anti-cytokine storm activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Weiwei Guo, Qianxiao Zhang, Yu Du, Junting Guo, Tingting Zhao, Liping Bai, Xiqiang An
Summary: The immunomodulatory activity of polysaccharides from Brassica rapa roots was investigated in this study. The results demonstrated that the polysaccharides exhibited a significant phagocytic capacity in macrophages, increased the production of nitric oxide and tumor necrosis factor alpha, and upregulated the mRNA levels of inducible nitric oxide synthase and tumor necrosis factor alpha. Furthermore, the modulation of macrophages by these polysaccharides was mediated through the activation of Akt and nuclear factor-kappa B. Therefore, polysaccharides from Brassica rapa roots have the potential to be used as an immunotherapeutic adjuvant for the treatment of inflammatory diseases.
CHINESE HERBAL MEDICINES
(2022)
Article
Microbiology
Mengxin Geng, Limei Ai, Ming Ma, Panpan Li, Lianhong Guo, Guangzhi Shan, Liping Bai
Summary: In this study, the disruption of ste2 in Streptomyces sp. 139 led to increased Ebosin production and altered gene transcription within the biosynthetic gene cluster. RNA sequencing data indicated decreased carbon and nitrogen source utilization, enhanced sensitivity to oxidative stress, and changed strain morphology. Overall, Ste2 plays a crucial role in controlling Ebosin yields, aminosugars uptake, sensitivity to oxidative stress, and morphological differentiation in Streptomyces sp. 139.
Article
Immunology
Yang Zhang, Lifei Wang, Liping Bai, Rong Jiang, Jianbo Wu, Yuan Li
Summary: Ebosin has been found to exert anti-inflammatory effects by suppressing the activation of MAPK and NF-κB pathways in rheumatoid arthritis.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Mengqi Wang, Jingyu Ren, Zhanpeng Liu, Shubin Li, Liya Su, Biao Wang, Daoning Han, Gang Liu
Summary: In this study, the beneficial effects of selenium doped carbon quantum dots (Se/CDs) on the in vitro development competence of ovine oocytes were investigated. The supplementation of Se/CDs during the in vitro maturation process enhanced the maturation rate, cortical granules' dynamics, mitochondrial activity, and embryonic developmental competence of ovine oocytes. It also decreased reactive oxygen species (ROS) production and up-regulated the expression levels of epigenetic modifications and differentially expressed genes (DEGs) related to oocyte maturation and mitochondrial functions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Medicinal
Weiwei Guo, Xiujun Liu, Junting Guo, Ruijuan Gao, Xiaodong Xiang, Xiqiang An, Liping Bai
Summary: Brassica rapa polysaccharides (BRP) have been shown to have anti-tumor effects by regulating macrophage polarization, promoting M1 markers expression and inhibiting M2 markers expression.
PHYTOTHERAPY RESEARCH
(2022)
Article
Environmental Sciences
Jingyu Ren, Biao Wang, Liping Li, Shubin Li, Yuzhen Ma, Liya Su, Gang Liu, Yongbin Liu, Yanfeng Dai
Summary: This study aimed to analyze the effect of copper sulfate (CuSO4) exposure on the meiotic potential of ovine oocytes, and investigate the ameliorative effect of glutathione (GSH) supplementation on the meiotic defects of CuSO4-exposed ovine oocytes. The results showed that excessive Cu exposure triggered meiotic defects in ovine oocytes by promoting mitochondrial dysfunction-related oxidative stress damage. GSH supplementation not only improved the maturation potential and fertilization defects of CuSO4-exposed oocytes, but also inhibited mitochondrial dysfunction-related oxidative stress damage, reducing oxidative stress and apoptosis, and altering H3K27me3 expression in CuSO4-exposed oocytes. These findings provide a basis for the ameliorative effect of GSH supplementation on meiotic defects in CuSO4-exposed oocytes, and further benefit potential applications in mammalian in vitro maturation (IVM) systems and livestock breeding suffering from excessive Cu exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Wenqi Zhang, Jiaxin Sun, Fangyuan Liu, Shubin Li, Xianjue Wang, Liya Su, Gang Liu
Summary: The current study aimed to investigate the alleviative effect of lactoferrin interventions against hepatotoxicity induced by titanium dioxide nanoparticles (TiO2-NPs). The results showed that after 4 weeks of treatment, interventions with 200 mg/kg lactoferrin not only improved liver dysfunction and histopathological damage caused by TiO2-NP exposure but also inhibited oxidative stress-related damage, inflammation, fibrosis, DNA damage, and apoptosis in the liver tissues. The transcriptomic results confirmed that the alleviative effect of lactoferrin interventions against TiO2-NP-induced hepatotoxicity was related to the activation of the PI3K/AKT signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Veterinary Sciences
Shubin Li, Jingyu Ren, Wenqi Zhang, Biao Wang, Yuzhen Ma, Liya Su, Yanfeng Dai, Gang Liu
Summary: The synergistic protective effect of co-supplementation of glutathione (GSH) with selenium nanoparticles (SeNPs) on the cryopreservation efficiency of bull semen was analyzed in this study. The results showed that co-supplementation of GSH with SeNPs effectively protected bull spermatozoa, improved sperm motility and viability, and enhanced antioxidant capacity and embryonic development potential.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Xianjue Wang, Ping Wei, Ling Yang, Fangyuan Liu, Xin Tong, Xiaoyu Yang, Liya Su
Summary: The study revealed that miR-20a-5p is significantly upregulated in HCC tissues, promoting cell proliferation, migration, and invasion while suppressing apoptosis through regulating the EMT process. Additionally, by downregulating RUNX3, miR-20a-5p activates the EMT pathway, enhancing the malignant behavior of HCC cells.
CHINESE MEDICAL JOURNAL
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)