An Alternatingly Amphiphilic, Resistance-Resistant Antimicrobial Oligoguanidine with Dual Mechanisms of Action

A Deep Learning Approach to Antibiotic Discovery

(2020) Jonathan M. Stokes et al.   CELL

Insights into the Polyhexamethylene Biguanide (PHMB) Mechanism of Action on Bacterial Membrane and DNA: A Molecular Dynamics Study

(2020) Shahin Sowlati-Hashjin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Antimicrobial peptides: Application informed by evolution

(2020) Brian P. Lazzaro et al.   SCIENCE

Designer broad-spectrum polyimidazolium antibiotics

(2020) Wenbin Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

(2019) Mike Tyers et al.   NATURE REVIEWS MICROBIOLOGY

Antibacterial activity of cationic polymers: side-chain or main-chain type?

(2018) Jiangna Guo et al.   Polymer Chemistry

Self-assembly of Amphiphilic Alternating Copolymers

(2018) Qingsong Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antimicrobial cationic polymers: from structural design to functional control

(2017) Yuchong Yang et al.   POLYMER JOURNAL

Molecular mechanisms of membrane targeting antibiotics

(2016) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Multidrug-Resistant Bacteria in the Community

(2016) David van Duin et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

(2016) Yugang Bai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes

(2016) Kantaraja Chindera et al.   Scientific Reports

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

(2016) Shu J. Lam et al.   Nature Microbiology

Helical antimicrobial polypeptides with radial amphiphilicity

(2015) Menghua Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

(2014) Konstantin Andreev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–activity relationships of guanylated antimicrobial polymethacrylates

(2014) Katherine E.S. Locock et al.   PURE AND APPLIED CHEMISTRY

Resistance-resistant antibiotics

(2014) Eric Oldfield et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design and synthesis of membrane-targeting antibiotics: from peptides- to aminosugar-based antimicrobial cationic amphiphiles

(2014) Ido M. Herzog et al.   MedChemComm

The DNA intercalators ethidium bromide and propidium iodide also bind to core histones

(2014) Amrita Banerjee et al.   FEBS Open Bio

Antimicrobial Polycarbonates: Investigating the Impact of Balancing Charge and Hydrophobicity Using a Same-Centered Polymer Approach

(2013) Amanda C. Engler et al.   BIOMACROMOLECULES

Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles

(2013) Zhan Yuin Ong et al.   BIOMATERIALS

Carbapenem-resistant Enterobacteriaceae: A menace to our most vulnerable patients

(2013) F. Perez et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Antimicrobial peptides and induced membrane curvature: Geometry, coordination chemistry, and molecular engineering

(2013) Nathan W. Schmidt et al.   CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent

(2012) Lihong Liu et al.   BIOMATERIALS

Predictors of mortality in patients with infections due to multi-drug resistant Gram negative bacteria: The study, the patient, the bug or the drug?

(2012) Konstantinos Z. Vardakas et al.   JOURNAL OF INFECTION

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents

(2010) Nikken Wiradharma et al.   BIOMATERIALS

Mimicking multipass transmembrane proteins: synthesis, assembly and folding of alternating amphiphilic multiblock molecules in liposomal membranes

(2010) Takahiro Muraoka et al.   CHEMICAL COMMUNICATIONS

Alternating Amphiphilic Multiblock Copolymers: Controlled Synthesis via RAFT Polymerization and Aqueous Solution Characterization

(2010) Natalie A. Hadjiantoniou et al.   MACROMOLECULES

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent

(2009) Lihong Liu et al.   Nature Nanotechnology

Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37

(2008) A. A. Stromstedt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthetic Mimic of Antimicrobial Peptide with Nonmembrane-Disrupting Antibacterial Properties

(2008) Gregory J. Gabriel et al.   BIOMACROMOLECULES

Comparison of Facially Amphiphilic versus Segregated Monomers in the Design of Antibacterial Copolymers

(2008) Gregory J. Gabriel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach

(2008) Karen Lienkamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY