Polyglycerol for Half-Life Extension of Proteins—Alternative to PEGylation?

Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation

(2020) Jessica K. Simmons et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

(2020) Gergely Tibor Kozma et al.   ADVANCED DRUG DELIVERY REVIEWS

Genetic Code Expansion Enables Site-Specific PEGylation of a Human Growth Hormone Receptor Antagonist through Click Chemistry

(2020) KYLE TAMSHEN et al.   BIOCONJUGATE CHEMISTRY

Structure‐Based Site‐Specific PEGylation of Fibroblast Growth Factor 2 Facilitates Rational Selection of Conjugate Sites

(2019) Jing Zhao et al.   Biotechnology Journal

Polysarcosine as an Alternative to PEG for Therapeutic Protein Conjugation

(2018) Yali Hu et al.   BIOCONJUGATE CHEMISTRY

Prospects of PASylation® for the design of protein and peptide therapeutics with extended half-life and enhanced action

(2018) Michaela Gebauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy

(2018) Liang Cheng et al.   Advanced Healthcare Materials

Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone

(2017) Ling Wu et al.   JOURNAL OF CONTROLLED RELEASE

An “Iceberg” Coating Preserves Bulk Hydration Dynamics in Aqueous PEG Solutions

(2017) Kimberly R. Daley et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Targeting the N terminus for site-selective protein modification

(2017) Christian B Rosen et al.   Nature Chemical Biology

Selective N-terminal functionalization of native peptides and proteins

(2017) Diao Chen et al.   Chemical Science

Site-Specific POxylation of Interleukin-4

(2017) Tessa Lühmann et al.   ACS Biomaterials-Science & Engineering

Site-Specific POxylation of Interleukin-4

(2017) Tessa Lühmann et al.   ACS Biomaterials Science & Engineering

Immediate-type hypersensitivity to polyethylene glycols: a review

(2016) E. Wenande et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Half-life extended biotherapeutics

(2016) Roland E. Kontermann   EXPERT OPINION ON BIOLOGICAL THERAPY

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Water Dynamics in Cytoplasm-Like Crowded Environment Correlates with the Conformational Transition of the Macromolecular Crowder

(2016) Pramod Kumar Verma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reversible Bioconjugation: Biodegradable Poly(phosphate)-Protein Conjugates

(2016) Tobias Steinbach et al.   MACROMOLECULAR BIOSCIENCE

Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters

(2015) William R. Strohl   BIODRUGS

Protein–polymer conjugation—moving beyond PEGylation

(2015) Yizhi Qi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Head to Head Comparison of the Formulation and Stability of Concentrated Solutions of HESylated versus PEGylated Anakinra

(2015) Robert Liebner et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Preferential Interactions and the Effect of Protein PEGylation

(2015) Louise Stenstrup Holm et al.   PLoS One

Enzymatically crosslinked dendritic polyglycerol nanogels for encapsulation of catalytically active proteins

(2015) Changzhu Wu et al.   Soft Matter

Anti-PEG antibody bioanalysis: a clinical case study with PEG-IFN-λ-1a and PEG-IFN-α2a in naive patients

(2015) Heather Myler et al.   Bioanalysis

Protein HESylation for half-life extension: Synthesis, characterization and pharmacokinetics of HESylated anakinra

(2014) Robert Liebner et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo

(2014) Mi Liu et al.   Nature Communications

Binding characteristics between polyethylene glycol (PEG) and proteins in aqueous solution

(2014) Jiang Wu et al.   Journal of Materials Chemistry B

Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration

(2013) Amr S. Abu Lila et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Application of Polyglycerol Coating to Plasmid DNA Lipoplex for the Evasion of the Accelerated Blood Clearance Phenomenon in Nucleic Acid Delivery

(2013) Amr S. Abu Lila et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular Insight into the Steric Shielding Effect of PEG on the Conjugated Staphylokinase: Biochemical Characterization and Molecular Dynamics Simulation

(2013) Qimeng Mu et al.   PLoS One

Squaric Acid Mediated Synthesis and Biological Activity of a Library of Linear and Hyperbranched Poly(Glycerol)–Protein Conjugates

(2012) Frederik Wurm et al.   BIOMACROMOLECULES

Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution

(2012) Muhammad Imran ul-haq et al.   BIOMATERIALS

Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules

(2012) Dirk Steinhilber et al.   JOURNAL OF CONTROLLED RELEASE

Effect of PEGylation on Protein Hydrodynamics

(2012) Yatin R. Gokarn et al.   MOLECULAR PHARMACEUTICS

How PEGylation Enhances the Stability and Potency of Insulin: A Molecular Dynamics Simulation

(2011) Cheng Yang et al.   BIOCHEMISTRY

Pharmacokinetics and Pharmacodynamics of Pegfilgrastim

(2011) Bing-Bing Yang et al.   CLINICAL PHARMACOKINETICS

Effects of PEG size on structure, function and stability of PEGylated BSA

(2011) Bitten Plesner et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

(2010) Yong Zhang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

(2009) Volker Schellenberger et al.   NATURE BIOTECHNOLOGY

PEGylation of rhIL-1RA increased its solution stability at room temperature

(2009) Pengzhan Yu et al.   PROCESS BIOCHEMISTRY

A summary of the measured pKvalues of the ionizable groups in folded proteins

(2009) Gerald R. Grimsley et al.   PROTEIN SCIENCE

Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsin

(2008) Benjaporn Treetharnmathurot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of PEGylation on the Solution Conformation of Antibody Fragments

(2007) Yanling Lu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES