Microvascular contribution to late-onset depression: mechanisms, current evidence, association with other brain diseases, and therapeutic perspectives
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Microvascular contribution to late-onset depression: mechanisms, current evidence, association with other brain diseases, and therapeutic perspectives
Authors
Keywords
late-onset depression, human studies, vascular depression, microvasculature, diabetes, hypertension
Journal
BIOLOGICAL PSYCHIATRY
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-04-28
DOI
10.1016/j.biopsych.2021.04.012
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Angiotensin-converting enzyme inhibitor rapidly ameliorates depressive-type behaviors via bradykinin-dependent activation of mTORC1
- (2020) Han Luo et al. BIOLOGICAL PSYCHIATRY
- The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study
- (2020) Bruno Agustini et al. JOURNAL OF HUMAN HYPERTENSION
- Mechanisms of Vascular Aging, A Geroscience Perspective
- (2020) Zoltan Ungvari et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
- (2020) Katarzyna A. Dudek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients
- (2020) Richard J. Shaw et al. PSYCHOLOGICAL MEDICINE
- Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank Population Study
- (2020) Alex Dregan et al. JAMA Psychiatry
- Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression
- (2020) Thomas T van Sloten et al. Lancet Diabetes & Endocrinology
- Type 2 Diabetes, Change in Depressive Symptoms Over Time, and Cerebral Small Vessel Disease: Longitudinal Data of the AGES-Reykjavik Study
- (2020) Sytze P. Rensma et al. DIABETES CARE
- Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms
- (2020) Anouk F.J. Geraets et al. HYPERTENSION
- Cerebral Small‐Vessel Disease and Risk of Incidence of Depression: A Meta‐Analysis of Longitudinal Cohort Studies
- (2020) Yuanyuan Fang et al. Journal of the American Heart Association
- Exercise interventions for the prevention of depression: a systematic review of meta-analyses
- (2020) Mandy X. Hu et al. BMC PUBLIC HEALTH
- Antihypertensive Drugs and Risk of Depression
- (2020) Lars Vedel Kessing et al. HYPERTENSION
- Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review
- (2020) Young Sup Woo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity
- (2020) Elles P. Elschot et al. INVESTIGATIVE RADIOLOGY
- Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI
- (2020) Tine Arts et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- The impact of adult behavioural weight management interventions on mental health: A systematic review and meta‐analysis
- (2020) Rebecca A. Jones et al. Obesity Reviews
- Impaired cerebral hemodynamics in late-onset depression: computed tomography angiography, computed tomography perfusion, and magnetic resonance imaging evaluation
- (2020) Jinhong Wang et al. Quantitative Imaging in Medicine and Surgery
- Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study
- (2020) Naiara Demnitz et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials
- (2019) O. Köhler‐Forsberg et al. ACTA PSYCHIATRICA SCANDINAVICA
- Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations
- (2019) Michael J. Thrippleton et al. Alzheimers & Dementia
- Neurobiology of Resilience: Interface Between Mind and Body
- (2019) Flurin Cathomas et al. BIOLOGICAL PSYCHIATRY
- Small vessel disease: mechanisms and clinical implications
- (2019) Joanna M Wardlaw et al. LANCET NEUROLOGY
- Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes
- (2019) Natalia de M. Lyra e Silva et al. Frontiers in Psychiatry
- Immune mechanisms of stress susceptibility and resilience: Lessons from animal models
- (2019) Mariya Tsyglakova et al. FRONTIERS IN NEUROENDOCRINOLOGY
- Macrovasculature and Microvasculature at the Crossroads Between Type 2 Diabetes Mellitus and Hypertension
- (2019) Rachel E. Climie et al. HYPERTENSION
- Compromised Dynamic Cerebral Autoregulation in Patients With Depression
- (2019) Ming-Ya Luo et al. Frontiers in Psychiatry
- Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
- (2019) Katarzyna A. Dudek et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Mechanisms and treatment of late-life depression
- (2019) George S. Alexopoulos Translational Psychiatry
- Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability
- (2019) Yue Zhang et al. BIOLOGICAL PSYCHIATRY
- Empirical support for the vascular apathy hypothesis: A structured review
- (2019) Lonneke Wouts et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Do statins have an effect on depressive symptoms? A systematic review and meta-analysis
- (2019) Megha Sai Yatham et al. JOURNAL OF AFFECTIVE DISORDERS
- Microvascular Dysfunction Is Associated With Worse Cognitive Performance
- (2019) Sytze P. Rensma et al. HYPERTENSION
- Distinct effects of antihypertensives on depression in the real-world setting: A retrospective cohort study
- (2019) Y.Y. Cao et al. JOURNAL OF AFFECTIVE DISORDERS
- Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke
- (2019) Jason P. Appleton et al. NEUROLOGY
- Microvascular Endothelial Function and Neurocognition among Adults with Major Depressive Disorder
- (2018) Smith PJ et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice
- (2018) Yuyan Cheng et al. BRAIN BEHAVIOR AND IMMUNITY
- Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression
- (2018) Robert Briggs et al. HYPERTENSION
- Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression
- (2018) Margarita Abi Zeid Daou et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
- (2018) Melanie D. Sweeney et al. Nature Reviews Neurology
- Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis
- (2018) Sytze P. Rensma et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Association of Apathy With Risk of Incident Dementia
- (2018) Jan Willem van Dalen et al. JAMA Psychiatry
- Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences
- (2018) Coen D.A. Stehouwer DIABETES
- Relationship between cerebral blood flow estimated by transcranial Doppler ultrasound and single photon emission computed tomography in elderly with dementia
- (2018) Taiki Miyazawa et al. JOURNAL OF APPLIED PHYSIOLOGY
- Perspectives on the Management of Vascular Depression
- (2018) Warren D. Taylor et al. AMERICAN JOURNAL OF PSYCHIATRY
- Carotid Artery Stiffness and Incident Depressive Symptoms: The Paris Prospective Study III
- (2018) Thomas T. van Sloten et al. BIOLOGICAL PSYCHIATRY
- Blood-Brain Barrier: From Physiology to Disease and Back
- (2018) Melanie D. Sweeney et al. PHYSIOLOGICAL REVIEWS
- Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing
- (2017) Michael J Thrippleton et al. International Journal of Stroke
- Management of Depression in Older Adults
- (2017) Rob M. Kok et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Cardiovascular risk factors and risk of incident depression throughout adulthood among men: The Johns Hopkins Precursors Study
- (2017) Nicole M. Armstrong et al. JOURNAL OF AFFECTIVE DISORDERS
- Frontocingulate cerebral blood flow and cerebrovascular reactivity associated with antidepressant response in late-life depression
- (2017) Margarita Abi Zeid Daou et al. JOURNAL OF AFFECTIVE DISORDERS
- Assessing Microvascular Function in Humans from a Chronic Disease Perspective
- (2017) Alfons J.H.M. Houben et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Social stress induces neurovascular pathology promoting depression
- (2017) Caroline Menard et al. NATURE NEUROSCIENCE
- Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
- (2017) Kassandra Kisler et al. NATURE REVIEWS NEUROSCIENCE
- Imaging retina to study dementia and stroke
- (2017) Carol Yim-lui Cheung et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Effects of psychopharmacological treatment with antidepressants on the vascular system
- (2017) Kai G. Kahl et al. VASCULAR PHARMACOLOGY
- Cerebral blood flow changes in remitted early- and late-onset depression patients
- (2017) Wenxiang Liao et al. Oncotarget
- Trajectories of Depressive Symptoms Before Diagnosis of Dementia
- (2017) Archana Singh-Manoux et al. JAMA Psychiatry
- Association of Microvascular Dysfunction With Late-Life Depression
- (2017) Marnix J. M. van Agtmaal et al. JAMA Psychiatry
- The Effect of Concomitant Treatment With SSRIs and Statins: A Population-Based Study
- (2016) Ole Köhler et al. AMERICAN JOURNAL OF PSYCHIATRY
- Vascular depression consensus report – a critical update
- (2016) Howard J. Aizenstein et al. BMC Medicine
- Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular DysfunctionClinical Perspective
- (2016) Ben M. Sörensen et al. CIRCULATION
- Monotherapy With Major Antihypertensive Drug Classes and Risk of Hospital Admissions for Mood DisordersNovelty and Significance
- (2016) Angela H. Boal et al. HYPERTENSION
- Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study
- (2016) Thomas T. van Sloten et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience
- (2016) Caroline Ménard et al. NEUROPSYCHOPHARMACOLOGY
- Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study
- (2015) Thomas T. van Sloten et al. AMERICAN JOURNAL OF PSYCHIATRY
- On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes
- (2015) Frank C. van Bussel et al. DIABETES CARE
- Pharmacological Treatment and Prevention of Cerebral Small Vessel Disease: A Review of Potential Interventions
- (2015) Philip M. Bath et al. International Journal of Stroke
- Longitudinal change of small-vessel disease-related brain abnormalities
- (2015) Reinhold Schmidt et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Management of late-life depression: a major leap forward
- (2015) Alan Thomas et al. LANCET
- Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis
- (2015) Thomas T. van Sloten et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Integrative regulation of human brain blood flow
- (2014) Christopher K. Willie et al. JOURNAL OF PHYSIOLOGY-LONDON
- Chronic variable stress activates hematopoietic stem cells
- (2014) Timo Heidt et al. NATURE MEDICINE
- Reduced cerebral perfusion predicts greater depressive symptoms and cognitive dysfunction at a 1-year follow-up in patients with heart failure
- (2013) Michael L. Alosco et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
- (2013) Joanna M Wardlaw et al. LANCET NEUROLOGY
- The vascular depression hypothesis: mechanisms linking vascular disease with depression
- (2013) W D Taylor et al. MOLECULAR PSYCHIATRY
- The brain reward circuitry in mood disorders
- (2013) Scott J. Russo et al. NATURE REVIEWS NEUROSCIENCE
- Cerebral Hemodynamics and Incident Depression: The Rotterdam Study
- (2012) Nese Direk et al. BIOLOGICAL PSYCHIATRY
- Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder
- (2012) Grazyna Rajkowska et al. BIOLOGICAL PSYCHIATRY
- Antidepressants in elderly: Metaregression of double-blind, randomized clinical trials
- (2012) Raffaella Calati et al. JOURNAL OF AFFECTIVE DISORDERS
- The capillary dysfunction hypothesis of Alzheimer's disease
- (2012) Leif Østergaard et al. NEUROBIOLOGY OF AGING
- Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik Study
- (2011) Gary F. Mitchell et al. BRAIN
- Neuropathological correlates of late-life depression in older people
- (2011) Christos Tsopelas et al. BRITISH JOURNAL OF PSYCHIATRY
- Depression and Risk of Stroke Morbidity and Mortality
- (2011) An Pan et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: Age-dependent changes
- (2011) Jose Javier Miguel-Hidalgo et al. JOURNAL OF AFFECTIVE DISORDERS
- Efficacy of Antidepressants for Late-Life Depression
- (2011) Enrico Tedeschini et al. JOURNAL OF CLINICAL PSYCHIATRY
- Depression and Risk of Stroke
- (2011) Jia-Yi Dong et al. STROKE
- Retinal Vascular Calibers and Risk of Late-Life Depression: The Rotterdam Study
- (2010) M. Kamran Ikram et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Assessment of cerebrovascular reactivity during major depression and after remission of disease
- (2010) Alireza Vakilian et al. Annals of Indian Academy of Neurology
- MRI signal hyperintensities and treatment remission of geriatric depression
- (2010) Faith M. Gunning-Dixon et al. JOURNAL OF AFFECTIVE DISORDERS
- The relationship between blood pressure and cognitive function
- (2010) Vera Novak et al. Nature Reviews Cardiology
- Neuropathological analysis of lacunes and microvascular lesions in late-onset depression
- (2010) M. Santos et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Review: Cerebral microvascular pathology in ageing and neurodegeneration
- (2010) W. R. Brown et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Evidence of Early Retinal Microvascular Changes in Patients With Type 2 Diabetes and Depression
- (2010) Thanh Tan Nguyen et al. PSYCHOSOMATIC MEDICINE
- Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation
- (2009) Philip N. Ainslie et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Reproducibility of the Retinal Vascular Response to Flicker Light in Asians
- (2009) Thanh T. Nguyen et al. CURRENT EYE RESEARCH
- Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: Identification of subgroups with immune responses and blood–CSF barrier dysfunction
- (2009) K. Bechter et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Cerebrovascular reactivity over time-course – From major depressive episode to remission
- (2009) Harald Lemke et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Apathy: A Common Psychiatric Syndrome in the Elderly
- (2009) Shinya Ishii et al. Journal of the American Medical Directors Association
- Effects of stress throughout the lifespan on the brain, behaviour and cognition
- (2009) Sonia J. Lupien et al. NATURE REVIEWS NEUROSCIENCE
- Differential Impact of Lacunes and Microvascular Lesions on Poststroke Depression
- (2009) Micaela Santos et al. STROKE
- Cerebrovascular risk factors and incident depression in community-dwelling elderly
- (2008) H. J. Luijendijk et al. ACTA PSYCHIATRICA SCANDINAVICA
- Vascular Disease and Future Risk of Depressive Symptomatology in Older Adults: Findings from the Health, Aging, and Body Composition Study
- (2008) Benjamin T. Mast et al. BIOLOGICAL PSYCHIATRY
- Vascular risk and depression in the Hispanic Established Population for the Epidemiologic Study of the Elderly (EPESE)
- (2008) Jennifer A. Zimmerman et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage
- (2008) Gary F. Mitchell JOURNAL OF APPLIED PHYSIOLOGY
- Cerebrovascular reactivity in depressed patients without vascular risk factors
- (2006) A. Gómez-Carrillo de Castro et al. JOURNAL OF PSYCHIATRIC RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started