Chemogenetic manipulation of astrocytic activity: Is it possible to reveal the roles of astrocytes?

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

(2020) Michelle Corkrum et al.   NEURON

Optimizing clozapine for chemogenetic neuromodulation of somatosensory cortex

(2020) Jongwook Cho et al.   Scientific Reports

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

Gi/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

(2019) Caitlin A. Durkee et al.   GLIA

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

(2019) Jun Nagai et al.   CELL

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

(2019) J. Christopher Octeau et al.   Cell Reports

Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

(2019) Min-Ho Nam et al.   Cell Reports

Opioid-Mediated Astrocyte–Neuron Signaling in the Nucleus Accumbens

(2019) Michelle Corkrum et al.   Cells

Role of astrocyte purinergic signaling in epilepsy

(2019) Ljiljana Nikolic et al.   GLIA

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Astroglial CB 1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

(2018) Laurie M. Robin et al.   NEURON

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior

(2018) Xinzhu Yu et al.   NEURON

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice

(2018) Daniel F. Manvich et al.   Scientific Reports

Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis

(2018) Ljiljana Nikolic et al.   GLIA

Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells

(2018) Marco Matos et al.   Nature Communications

Astrocytes integrate and drive action potential firing in inhibitory subnetworks

(2018) Tara Deemyad et al.   Nature Communications

Synapse-specific astrocyte gating of amygdala-related behavior

(2017) Mario Martin-Fernandez et al.   NATURE NEUROSCIENCE

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

(2017) Zhibing Tan et al.   Nature Communications

An autocrine purinergic signaling controls astrocyte-induced neuronal excitation

(2017) Weida Shen et al.   Scientific Reports

DREADDS: Use and application in behavioral neuroscience.

(2016) Kyle S. Smith et al.   BEHAVIORAL NEUROSCIENCE

Purinergic signaling in epilepsy

(2016) François Rassendren et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Astrocytic GABA transporter activity modulates excitatory neurotransmission

(2016) Kim Boddum et al.   Nature Communications

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

(2016) Junhua Yang et al.   eLife

The Use of DREADDs to Deconstruct Behavior

(2016) Paul D. Whissell et al.   Frontiers in Genetics

Optogenetic Glia Manipulation: Possibilities and Future Prospects

(2016) Woo-Hyun Cho et al.   Experimental Neurobiology

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

(2015) Xin Chen et al.   ACS Chemical Neuroscience

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

(2015) Michael D. Scofield et al.   BIOLOGICAL PSYCHIATRY

Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

(2015) Zhi-Gang Ji et al.   BRAIN RESEARCH BULLETIN

Na+–Ca2+ exchanger mediates ChR2-induced [Ca2+]i elevation in astrocytes

(2015) Junhua Yang et al.   CELL CALCIUM

PAR1-Activated Astrocytes in the Nucleus of the Solitary Tract Stimulate Adjacent Neurons via NMDA Receptors

(2015) K. M. Vance et al.   JOURNAL OF NEUROSCIENCE

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

(2015) Eyal Vardy et al.   NEURON

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

(2015) Daniel J Urban et al.   NEUROPSYCHOPHARMACOLOGY

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

(2015) R. Martin et al.   SCIENCE

Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein

(2015) Baljit S. Khakh et al.   Cold Spring Harbor Perspectives in Biology

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

(2015) Liang Yang et al.   Cell Reports

Astrocyte Ca2+ signalling: an unexpected complexity

(2014) Andrea Volterra et al.   NATURE REVIEWS NEUROSCIENCE

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage

(2014) Kaoru Beppu et al.   NEURON

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

(2014) Cecilia Bull et al.   NEUROPSYCHOPHARMACOLOGY

Astroglial cradle in the life of the synapse

(2014) A. Verkhratsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

(2013) Fengfei Ding et al.   CELL CALCIUM

TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release

(2013) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Modulation of the autonomic nervous system and behaviour by acute glial cell Gqprotein-coupled receptor activationin vivo

(2013) Cendra Agulhon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

New tools for investigating astrocyte-to-neuron communication

(2013) Dongdong Li et al.   Frontiers in Cellular Neuroscience

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors

(2012) Sophie J. Bradley et al.   BIOCHEMICAL PHARMACOLOGY

Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release

(2012) Dongdong Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

GABA release by hippocampal astrocytes

(2012) Karim Le Meur et al.   Frontiers in Computational Neuroscience

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus

(2011) Mirko Santello et al.   NEURON

Remote Control of Neuronal Signaling

(2011) S. C. Rogan et al.   PHARMACOLOGICAL REVIEWS

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca2+ Signaling

(2010) C. Agulhon et al.   SCIENCE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential

(2009) Annalisa Buffo et al.   BIOCHEMICAL PHARMACOLOGY

Purinoceptors on Neuroglia

(2009) Alexei Verkhrasky et al.   MOLECULAR NEUROBIOLOGY

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

A chemical-genetic approach to study G protein regulation of β cell function in vivo

(2009) Jean-Marc Guettier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons

(2008) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Loss of IP3 Receptor-Dependent Ca2+ Increases in Hippocampal Astrocytes Does Not Affect Baseline CA1 Pyramidal Neuron Synaptic Activity

(2008) J. Petravicz et al.   JOURNAL OF NEUROSCIENCE

GABA, a forgotten gliotransmitter

(2008) María Cecilia Angulo et al.   PROGRESS IN NEUROBIOLOGY

Neuroglia: the 150 years after

(2008) Helmut Kettenmann et al.   TRENDS IN NEUROSCIENCES