Article
Agriculture, Multidisciplinary
Xuemeng Si, Zhuan Song, Ning Liu, Hai Jia, Haozhen Liu, Zhenlong Wu
Summary: This study found that alpha-ketoglutarate (alpha-KG) has preventive effects on Citrobacter rodentium-induced colitis by regulating endoplasmic reticulum stress and activating Wnt signaling to restore barrier function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Xin Xu, Yudong Feng, Chenjie Han, Zhengrong Yao, Yaxin Liu, Chi Luo, Jinghao Sheng
Summary: This study demonstrates the adverse effects of polystyrene nanoplastics (PS-NPs) on intestinal epithelial cells, showing that PS-NPs can affect cell growth and survival, impair autophagic flux, and induce autophagic response in vivo.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Yang Yang, Maria Gomez, Timothy Marsh, Laura Poillet-Perez, Akshada Sawant, Lei Chen, Noel R. Park, S. RaElle Jackson, Zhixian Hu, Noa Alon, Chen Liu, Jayanta Debnath, Jun-Lin Guan, Shawn Davidson, Michael Verzi, Eileen White
Summary: Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) and affect unknown mechanisms. Conditional deletion of specific genes Atg5 or Fip200/Atg17 causes death in mice through autophagy inhibition, loss of barrier function, and elimination of stem cells. Autophagy plays a crucial role in maintaining mesenchymal cell metabolism and intestinal stem cell renewal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Erpeng Yang, Jun Shen
Summary: Paneth cells play critical roles in controlling gut microbiota and maintaining intestinal homeostasis by secreting alpha-defensins. Inflammatory bowel disease, including Crohn's disease, is closely related to Paneth cells, which are identified as the central element of the pathogenesis.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Guillaume Dalmasso, Hang Thi Thu Nguyen, Tiphanie Fais, Sebastien Massier, Caroline Chevarin, Emilie Vazeille, Nicolas Barnich, Julien Delmas, Richard Bonnet
Summary: The study revealed that the yersiniabactin siderophore of AIEC provides an advantage for growth in competitive environments, but it also activates autophagy leading to bacterial clearance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mariana Borsa, Sandrine Obba, Felix C. Richter, Hanlin Zhang, Thomas Riffelmacher, Joana Carrelha, Ghada Alsaleh, Sten Eirik W. Jacobsen, Anna Katharina Simon
Summary: This study investigates the importance of autophagy in stem cells and finds that autophagy deficiency leads to stem cell loss and bone marrow failure, while inhibition of MTOR can rescue this loss and improve stem cell function.
Review
Biochemistry & Molecular Biology
Daniela Intartaglia, Giuliana Giamundo, Ivan Conte
Summary: The retinal pigment epithelium (RPE) plays a crucial role in maintaining the function of photoreceptors and responding to stress conditions. Autophagy is a cellular self-regulation process that helps in digestion and recycling of cell components to meet cellular demands.
Review
Biochemistry & Molecular Biology
Angel Cayo, Raul Segovia, Whitney Venturini, Rodrigo Moore-Carrasco, Claudio Valenzuela, Nelson Brown
Summary: Cellular senescence is a unique form of proliferative arrest triggered by various stimuli, characterized by changes in cell morphology and function. The activation of mTOR and autophagy play crucial roles in regulating different aspects of cellular senescence. Understanding and targeting the interconnected pathways of mTOR and autophagy could be key in developing anti-cancer therapies involving pro-senescence drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lluis Lis-Lopez, Cristina Bauset, Marta Seco-Cervera, Dulce Macias-Ceja, Francisco Navarro, Angeles Alvarez, Juan Vicente Esplugues, Sara Calatayud, Maria Dolores Barrachina, Dolores Ortiz-Masia, Jesus Cosin-Roger
Summary: The relevance of P2X7 receptor in complications of Crohn's Disease (CD) was analyzed in this study. It was found that intestinal fibrosis, a common complication in CD patients, is significantly increased and regulated by P2X7. Animal and cell experiments also confirmed the importance of P2X7 in this process. The lack of P2X7 aggravates intestinal fibrosis, while P2X7 regulates collagen expression in human intestinal fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nicolette M. Johnson, Louis R. Parham, Jeeyoon Na, Keara E. Monaghan, Hannah M. Kolev, Alena Klochkova, Melissa S. Kim, Charles H. Danan, Zvi Cramer, Lauren A. Simon, Kaitlyn E. Naughton, Stephanie Adams-Tzivelekidis, Yuhua Tian, Patrick A. Williams, N. Adrian Leu, Simone Sidoli, Kelly A. Whelan, Ning Li, Christopher J. Lengner, Kathryn E. Hamilton
Summary: The intestinal epithelium shows a quick and efficient regenerative response to injury. Research suggests that high autophagic vesicle content in secretory cells predicts cell plasticity and resistance to DNA damaging injury, regardless of cell age.
Review
Gastroenterology & Hepatology
Fei Gao, Hengwei Wu, Limengmeng Wang, Yanmin Zhao, He Huang
Summary: Despite advancements in HSCT, GVHD, especially intestinal GVHD, still poses a significant challenge to the procedure. Traditionally, GVHD has been seen as an immune response, with the intestine as a target. However, factors such as altered intestinal microbiome and epithelial damage contribute to intestinal damage after transplantation. This review summarizes these factors and explores the potential of remodeling intestinal homeostasis in GVHD management.
Article
Biochemistry & Molecular Biology
Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima
Summary: Crohn's disease is an inflammatory disease of the gut caused by a complex interplay among genetic, microbial, and environmental factors. The ingestion of nickel particles may worsen Crohn's disease by perturbing autophagic processes in the intestine.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Maria Virginia Giolito, Michelina Plateroti
Summary: Multiple studies have highlighted the role of thyroid hormones in stem cell biology, which is mediated through specific receptors. Previous research mainly focused on amphibians, but recent findings suggest that these findings also apply to mammals and have significant implications in intestinal epithelium stem cells and cancer stem cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Huldani Huldani, Ria Margiana, Fawad Ahmad, Maria Jade Catalan Opulencia, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Nargiza N. Abdullaeva, Homayoon Siahmansouri
Summary: Inflammatory bowel disease (IBD) is caused by various pathophysiologic pathways and immune-pathologic etiologies. Mesenchymal Stem Cells (MSCs) have been suggested as a potential treatment for IBD due to their immune regulatory functions. Clinical trials using MSCs from bone marrow, umbilical cord, and adipose tissue have shown promising results in terms of safety. However, further research is needed to obtain more reliable results and more support from laboratory evidence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Ana Krotenberg Garcia, Arianna Fumagalli, Huy Quang Le, Rene Jackstadt, Tamsin Rosemary Margaret Lannagan, Owen J. Sansom, Jacco van Rheenen, Saskia J. E. Suijkerbuijk
Summary: Competitive cell interactions between cancer cells and wild-type cells lead to the active elimination of normal cells and promotion of cancer cell proliferation. This process is driven by cell-state change in wild-type cells and activation of JNK signaling, ultimately resulting in the out-competition of normal cells by cancer cells.
Article
Cell Biology
Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, Muhammed A. Rahman, Shawn Winer, Daniel A. Winer, Catherine J. Streutker, Dana J. Philpott, Stephen E. Girardin
Article
Microbiology
Matthew T. Sorbara, Elisabeth G. Foerster, Jessica Tsalikis, Mena Abdel-Nour, Joseph Mangiapane, Imogen Sirluck-Schroeder, Ivan Tattoli, Rob van Dalen, David E. Isenman, John R. Rohde, Stephen E. Girardin, Dana J. Philpott
CELL HOST & MICROBE
(2018)
Review
Biochemistry & Molecular Biology
Tapas Mukherjee, Elise Sofie Hovingh, Elisabeth G. Foerster, Mena Abdel-Nour, Dana J. Philpott, Stephen E. Girardin
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Editorial Material
Microbiology
Elisabeth G. Foerster, Stephen E. Girardin
CELL HOST & MICROBE
(2019)
Article
Cell Biology
Charles Maisonneuve, Derek K. L. Tsang, Elisabeth G. Foerster, Lukian Maxence Robert, Tapas Mukherjee, Dave Prescott, Ivan Tattoli, Paul Lemire, Daniel A. Winer, Shawn Winer, Catherine J. Streutker, Kaoru Geddes, Ken Cadwell, Richard L. Ferrero, Alberto Martin, Stephen E. Girardin, Dana J. Philpott
Summary: The pioneering studies in the early 1980s indicated that bacterial peptidoglycan-derived muramyl peptides (MPs) have dual functions of either stimulation or immunosuppression depending on the chronicity of exposure. This study demonstrates the immunosuppressive potential of Nod1, the bacterial sensor of diaminopimelic acid (DAP)-containing MPs, in reprogramming macrophages and inducing myeloid-derived suppressor cells (MDSCs) to maintain their immunosuppressive activity, ultimately promoting tumor progression in colorectal cancer.
Article
Immunology
Kebria Hezaveh, Rahul S. Shinde, Andreas Kloetgen, Marie Jo Halaby, Sara Lamorte, M. Teresa Ciudad, Rene Quevedo, Luke Neufeld, Zhe Qi Liu, Robbie Jin, Barbara T. Grunwald, Elisabeth G. Foerster, Danica Chaharlangi, Mengdi Guo, Priya Makhijani, Xin Zhang, Trevor J. Pugh, Devanand M. Pinto, Ileana L. Co, Alison P. McGuigan, Gun Ho Jang, Rama Khokha, Pamela S. Ohashi, Grainne M. O'Kane, Steven Gallinger, William W. Navarre, Heather Maughan, Dana J. Philpott, David G. Brooks, Tracy L. McGaha
Summary: The study demonstrates the critical role of AhR in the function of tumor-associated macrophages (TAMs) in PDAC, showing that deletion of Ahr reduces PDAC growth, increases the frequency of IFN CD8(+) T cells, and dietary tryptophan metabolism affects AhR activity through the conversion of tryptophan to indoles by Lactobacillus. High AHR expression in PDAC patients is associated with disease progression, mortality, and an immune-suppressive TAM phenotype, indicating a conserved regulatory axis in human disease.
Article
Gastroenterology & Hepatology
Derek K. L. Tsang, Ryan J. Wang, Oliver De Sa, Arshad Ayyaz, Elisabeth G. Foerster, Giuliano Bayer, Shawn Goyal, Daniel Trcka, Bibaswan Ghoshal, Jeffrey L. Wrana, Stephen E. Girardin, Dana J. Philpott
Summary: This study used single-cell RNA sequencing to investigate the crosstalk between microbes and intestinal epithelial cells. The presence of microbiota did not significantly alter the overall cellular composition of the epithelium, but did induce changes in specific cell types and gene expression profiles. The findings suggest that microbe-derived metabolites directly activate and regulate mTOR signaling. Overall, this research provides valuable insights into the impact of the microbiota on the small intestinal epithelium.
Article
Immunology
Elisabeth G. Foerster, Derek K. L. Tsang, Shawn Goyal, Susan J. Robertson, Lukian M. Robert, Heather Maughan, Catherine J. Streutker, Stephen E. Girardin, Dana J. Philpott
Summary: The breakdown of the intestinal mucosal barrier is a key factor in the progression to Crohn disease (CD), and various risk factors, such as a genetic polymorphism of the autophagy gene ATG16L1, contribute to this process. The researchers investigated the role of Atg16l1 in protecting the small intestinal epithelium and found that its deficiency led to increased intestinal damage, inflammation, and reduced survival in mice. The study suggests that targeting interferon-gamma (IFN-gamma) may be a potential therapeutic approach for CD patients with ATG16L1 variants.
MUCOSAL IMMUNOLOGY
(2023)
