Article
Biotechnology & Applied Microbiology
Dana M. Piazza, Diana Romanini, Maria-Rocio Meini
Summary: Agro-industrial by-products can be used as sustainable natural alternatives to synthetic additives in the food industry. Grape pomace, which contains a significant amount of polyphenols, can be extracted using enzymes in an appropriate hydroalcoholic mixture. This study provides a basis for the precise extraction of desired polyphenols.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ebru Cenk, Cornelia Schmutz, Gudrun Pahlke, Anne Oertel, Jessica Kollarova, Hans-Peter Mock, Andrea Matros, Doris Marko
Summary: An anthocyanin-rich diet is believed to protect against chronic inflammation, despite the unclear immunomodulatory role of anthocyanins. The study found that cyanidin-3O-glucoside in blackberry juice can reduce TNF-alpha levels, indicating protective effects, but other fractions from blackberry juice may have pro-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
A. Gulcin Sagdicoglu Celep, Aslihan Demirkaya, Ebru Kondolot Solak
Summary: This study focused on the formation of GA-containing microspheres using NaAlg and the investigation of their release profile. The microspheres exhibited a controlled release profile and effectively retained the antioxidant and anticancer activities of GA. Further studies are needed to explore the potential application of GA-loaded NaAlg microspheres in adjunct and complementary therapies.
CURRENT APPLIED PHYSICS
(2022)
Article
Food Science & Technology
Menghua Lin, Chenchen Sun, Qingchao Gao, Zhiyong Zhang, Ying Liang, Shulin Wang
Summary: Purple cabbage is a potential natural colorant source for commercial beverages due to its high anthocyanin content, but its unstable characteristics limit its application in the food industry. This study investigated the effect of various polyphenols on the stability of purple cabbage anthocyanins in beverage systems. The results showed that gallic acid (GA) performed best in enhancing color stability and extending shelf life. This study provides a potential solution to enhance anthocyanin stability and extend beverage shelf life through GA addition.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Environmental Sciences
Christiana Mystrioti, Stefania Koursari, Anthimos Xenidis, Nymphodora Papassiopi
Summary: The study demonstrates that gallic acid is effective in rapidly reducing Cr(VI) to Cr(III) in mild acidic conditions, following 2nd order kinetics in the pH range 3-5, with a different reduction mechanism observed at pH 5 and pH 6.
Article
Food Science & Technology
Gontorn Putsakum, Katerina Tzima, Brijesh K. Tiwari, Colm P. O'Donnell, Dilip K. Rai
Summary: Limited research studies indicate that thermosonication (TS) processing has an impact on antioxidant compounds in blackberry juice. By adjusting the parameters of TS, such as temperature, amplitude power, and time, the retention of vitamin C, total phenolic content, DPPH, and FRAP in the juice can be improved. Both low-temperature and high-temperature treatments show higher retentions in these attributes compared to untreated and pasteurized juices. The retention of major polyphenols is also higher. Overall, TS treatment can be a viable alternative for producing antioxidant-rich blackberry juice, with effects on phytochemicals similar to pasteurization.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Meltem Turkyilmaz, Fatmagul Hamzaoglu, Rumeysa Betul Ari Ciftci, Mehmet Ozkan
Summary: The study aimed to reduce the degradation of pomegranate juice anthocyanins caused by HMF through phenolic acid copigmentation. Results showed that the addition of FA and GA reduced the degradation rate, while CA had a protective effect only at low concentrations.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Nutrition & Dietetics
Ran Hong, Sung-Chul Lim, Tae-Bum Lee, Song-Iy Han
Summary: The acidic tumor environment is an important factor in cancer metastasis. This study investigated the impact of an acidic environment on the metastatic properties of MCF7 breast cancer cells and examined the inhibitory effects of gallic acid. Prolonged exposure to acidic conditions induced the acquisition of migratory and invasive properties in MCF7 cells, which was accompanied by changes in the expression of certain proteins and markers. Gallic acid effectively inhibited the survival and reduced the metastatic characteristics of acidity-adapted MCF7 cells. This highlights the potential of gallic acid as a therapeutic agent for metastatic traits in breast cancer cells under acidic conditions.
Article
Plant Sciences
Daniel Moreno, Maria Victoria Alarcon, David Uriarte, Luis A. Mancha, Maria Esperanza Valdes
Summary: This study analyzes the effects of non-limiting irrigation and rainfed on grapevines with different shoot densities. The results show that irrigation leads to increased berry weight and yield, as well as variations in certain compound levels, depending on shoot density and season.
Article
Biochemistry & Molecular Biology
Shohreh Jafarinejad, William H. C. Martin, Bayan Abu Ras, Mohammad Isreb, Badie Jacob, Abid Aziz, Zahra Adoul, Ruby Lagnado, Richard D. Bowen, Mojgan Najafzadeh
Summary: The compound TMBS shows a stronger anticancer effect compared to GA, suppressing the growth and proliferation of lung cancer cells. Furthermore, TMBS does not show cytotoxicity to healthy cells, suggesting its potential for cancer therapeutics.
Article
Agriculture, Multidisciplinary
Eva Lopez-Rituerto, Klavs M. Sorensen, Francesco Savorani, Soren B. Engelsen, Alberto Avenoza, Jesus M. Peregrina, Jesus H. Busto
Summary: Proton nuclear magnetic resonance (H-1-NMR) is a quantitative and unbiased analytical technique that can be used to monitor quantitative changes in wine metabolites during the winemaking process. This study demonstrates the potential of NMR as a process analytical technology tool in the wine industry, by monitoring amino acids, organic acids, and polyphenols.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Organic
Francesc Navarro, Salha Hamri, Rosa Reches, Miquel Vinas, Daniel Jahani, Jaume Ginard, Josep Vilardell, Olga Abian, M. Dolors Pujol
Summary: Researchers have successfully synthesized ellagic acid from methyl gallate through a five-step synthetic route with a 38% overall yield. The synthesis involves ketal protection, regioselective bromination, bis-lactonization, C-C bond formation between the aromatic rings of the galloyl groups, and ketal deprotection. Ellagic acid exhibits slight inhibitory activity against SARS-CoV-2 3CLpro.
SYNTHESIS-STUTTGART
(2023)
Review
Pharmacology & Pharmacy
Giuseppe Angellotti, Giulia Di Prima, Elena Belfiore, Giuseppina Campisi, Viviana De Caro
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive cancer, and conventional treatments have limitations. Resveratrol (RSV), a natural compound, has shown potential for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. RSV also synergizes with chemotherapeutics and overcomes drug resistance. However, there is a lack of specific investigations on RSV's effects in different administration routes and vehicles. RSV-loaded liposomes have demonstrated efficacy against OSCC models, suggesting the development of drug delivery systems as a turning point in oral cancer treatment.
Article
Genetics & Heredity
Jaciara Neves Sousa, Lorena dos Reis Pereira Queiroz, Alfredo Mauricio Batista de Paula, Andre Luiz Sena Guimaraes, Caroline Honaiser Lescano, Charles Martins Aguilar, Ivan Pires de Oliveira, Sergio Henrique Sousa Santos
Summary: Studies have shown that gallic acid (GA) has the potential to promote weight loss and improve glycemic parameters. This study investigated the activating potential of GA on Sestrin using molecular docking. The results revealed that specific amino acids play a crucial role in stabilizing GA and activating SESN2, similar to the interaction that allows leucine to activate SESN2. Therefore, the anti-obesity property of GA may be achieved through the activation of Sestrin.
Article
Biochemistry & Molecular Biology
Thais Silva da Rocha, Alessandro de Lima, Jurandy do Nascimento Silva, Geni Rodrigues Sampaio, Rosana Aparecida Manolio Soares Freitas, Renan Danielski, Adriano Costa de Camargo, Fereidoon Shahidi, Elizabeth Aparecida Ferraz da Silva Torres
Summary: Jua, an underexplored fruit from Brazil, is rich in antioxidant substances. This study found that ultrasound-assisted extraction with water as the solvent resulted in the highest total phenolic content and antiradical activity. The extracted pulp from Jua contains ellagic acid, which exhibits higher antioxidant activity compared to other well-known fruits. This study provides new information about the potential use of Jua as a source of phenolic compounds.
Article
Chemistry, Applied
Seyed Mohammad Hashem Hosseini, Hadi Hashemi Gahruie, Maryam Razmjooie, Marziyeh Sepeidnameh, Mahsa Rastehmanfard, Mohsen Tatar, Fakhraddin Naghibalhossaini, Paul Van der Meeren
Article
Oncology
Mohsen Tatar, Zohreh Bagheri, Masoumeh Varedi, Fakhraddin Naghibalhossaini
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2019)
Article
Chemistry, Applied
Nazanin Ghayour, Seyed Mohammad Hashem Hosseini, Mohammad Hadi Eskandari, Sara Esteghlal, Abdo-Reza Nekoei, Hadi Hashemi Gahruie, Mohsen Tatar, Fakhraddin Naghibalhossaini
FOOD HYDROCOLLOIDS
(2019)
Article
Oncology
Hajar Jaberie, Seyed Vahid Hosseini, Fakhraddin Naghibalhossaini
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Surgery
Mohammad S. Owji, Masoumeh Varedi, Fakhraddin Naghibalhossaini, Nasser Pajouhi
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Oncology
Mohsen Tatar, Masoumeh Varedi, Fakhraddin Naghibalhossaini
Summary: This study is the first to report the epigenetic effects of blackberry in cancer cells, including reduced expressions of DNMTs and HDACs, induced promoter DNA demethylation of certain genes, and increased expression of differentiation markers in colonic epithelial cells.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Fatemeh Ghiasi, Mohammad Hadi Eskandari, Mohammad Taghi Golmakani, Hadi Hashemi Gahruie, Reza Zarei, Fakhraddin Naghibalhossaini, Seyed Mohammad Hashem Hosseini
Summary: This study successfully developed a novel nanoencapsulation system using gelled lipid nanoparticles to improve the functionality, stability, and bioactivity of cuminaldehyde in food colloidal formulations. The encapsulated cuminaldehyde showed enhanced cytotoxic effects against cancer cells, improved antioxidant activity, and lipid oxidation stability. Additionally, the gelled lipid nanoparticles exhibited strong antibacterial activity against specific bacteria, highlighting their potential in enriching food and beverage formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Delaram Moghadam, Reza Zarei, Sina Vakili, Rozita Ghojoghi, Vahid Zarezade, Ali Veisi, Mohamad Sabaghan, Omid Azadbakht, Hamid Behrouj
Summary: This study reveals that low doses of polyphenols (Resveratrol, Gallic acid, and Kuromanin chloride) upregulate the expression of the hTERT gene in the HepG2 hepatocellular carcinoma cell line via induction of the SIRT1/Nrf2 signaling pathway. Additionally, Resveratrol and Kuromanin chloride alleviate oxidative stress, while Gallic acid exacerbates it. These findings suggest that by targeting this pathway or hTERT, the anticancer effect of polyphenols can be enhanced.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Cell Biology
Mohammad Samare-Najaf, Asma Neisy, Ali Samareh, Delaram Moghadam, Navid Jamali, Reza Zarei, Fatemeh Zal
Summary: Reproduction involves significant molecular, cellular, and tissue changes, and recent studies have highlighted the importance of basic molecular pathways, such as autophagy, in reproductive processes. This comprehensive review provides an up-to-date overview of the role of autophagy in male reproduction, including spermatogenesis, sperm motility and viability, and male sex hormones, as well as female reproduction, including germ cells and oocyte viability, ovulation, implantation, fertilization, and female sex hormones. The review also discusses the impact of disrupted autophagic flux on reproductive disorders, including infertility-related conditions such as oligospermia, azoospermia, asthenozoospermia, teratozoospermia, globozoospermia, premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, and others.
Article
Medicine, General & Internal
Asef Hormozi, Asadollah Zarifkar, Bahar Rostami, Fakhraddin Naghibalhossaini
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2019)