A Bimetallic Metal–Organic Framework Encapsulated with DNAzyme for Intracellular Drug Synthesis and Self‐Sufficient Gene Therapy

Polymer-Based Bioorthogonal Nanocatalyst for the Treatment of Bacterial Biofilms

(2020) Rui Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A smart theranostic nanocapsule for spatiotemporally programmable photo‐genetherapy

(2020) Xue Gong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs

(2020) Yanli Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNAzyme-Loading MOFs for Self-Sufficient Gene Therapy

(2019) Huimin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocompatible Heterogeneous MOF-Cu Catalyst Used for In Vivo Drug Synthesis at Targeted Subcellular Organelles

(2019) Xiaogang Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

(2019) María Sancho-Albero et al.   Nature Catalysis

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide

(2018) Yueqin Zheng et al.   Nature Chemistry

Nanomedicines reveal how PBOV1 promotes hepatocellular carcinoma for effective gene therapy

(2018) Yu Guo et al.   Nature Communications

Optical Control of Metal Ion Probes in Cells and Zebrafish Using Highly Selective DNAzymes Conjugated to Upconversion Nanoparticles

(2018) Zhenglin Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

(2018) Qingxin Yao et al.   Nature Communications

RNA-Cleaving DNAzymes: Old Catalysts with New Tricks for Intracellular and In Vivo Applications

(2018) JingJing Zhang   Catalysts

Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework

(2017) Shahad K. Alsaiari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Theranostic DNAzymes

(2017) Wenhu Zhou et al.   Theranostics

Copper Catalysis in Living Systems and In Situ Drug Synthesis

(2016) Jessica Clavadetscher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click and Release: A Chemical Strategy toward Developing Gasotransmitter Prodrugs by Using an Intramolecular Diels-Alder Reaction

(2016) Xingyue Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice

(2016) Raffaella Rossin et al.   BIOCONJUGATE CHEMISTRY

Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction

(2016) Inthirai Somasuntharam et al.   BIOMATERIALS

Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries

(2016) Xueshun Wang et al.   DRUG DISCOVERY TODAY

A Highly Efficient Single-Chain Metal–Organic Nanoparticle Catalyst for Alkyne–Azide “Click” Reactions in Water and in Cells

(2016) Yugang Bai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosome-Templated Azide–Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry

(2016) Ian Glassford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One-pot Synthesis of Metal–Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery

(2016) Haoquan Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Smart DNAzyme-MnO2Nanosystem for Efficient Gene Silencing

(2015) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper(I)-Catalyzed Interrupted Click Reaction: Synthesis of Diverse 5-Hetero-Functionalized Triazoles

(2015) Weiguo Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targeted Gene Regulation Therapy

(2015) Juan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition

(2015) Siddharth S. Matikonda et al.   Chemical Science

Translating Bacterial Detection by DNAzymes into a Litmus Test

(2014) Kha Tram et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment

(2014) Liping Qiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expression of early growth response-1 in human gastric cancer and its relationship with tumor cell behaviors and prognosis

(2013) Eun Myung et al.   PATHOLOGY RESEARCH AND PRACTICE

Dual-Function CXCR4 Antagonist Polyplexes To Deliver Gene Therapy and Inhibit Cancer Cell Invasion

(2012) Jing Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unimolecular Catalytic DNA Biosensor for Amplified Detection ofl-Histidine via an Enzymatic Recycling Cleavage Strategy

(2011) Rong-Mei Kong et al.   ANALYTICAL CHEMISTRY

Functional delivery of DNAzyme with iron oxide nanoparticles for hepatitis C virus gene knockdown

(2011) Soo-Ryoon Ryoo et al.   BIOMATERIALS

Cell-Specific, Activatable, and Theranostic Prodrug for Dual-Targeted Cancer Imaging and Therapy

(2011) Santimukul Santra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

(2011) Yu Xiang et al.   Nature Chemistry

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Amplified Detection of DNA through an Autocatalytic and Catabolic DNAzyme-Mediated Process

(2010) Fuan Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deoxyribozymes: Selection Design and Serendipity in the Development of DNA Catalysts†

(2009) Scott K. Silverman   ACCOUNTS OF CHEMICAL RESEARCH

Functional Nucleic Acid Sensors

(2009) Juewen Liu et al.   CHEMICAL REVIEWS

Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction

(2008) Philipp M. E. Gramlich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives

(2008) Joydeb Kumar Kundu et al.   CANCER LETTERS

A DNAzyme cascade for the amplified detection of Pb2+ ions or l-histidine

(2008) Johann Elbaz et al.   CHEMICAL COMMUNICATIONS

c-Jun knockdown sensitizes osteosarcoma to doxorubicin

(2008) C. R. Dass et al.   MOLECULAR CANCER THERAPEUTICS