Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation

Baseline and Evolutionary Radiologic Features in Sporadic, Hemorrhagic Brain Cavernous Malformations

(2019) K.D. Flemming et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cranial Cavernous Malformations

(2018) Christopher J. Stapleton et al.   STROKE

Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease

(2018) Muhammad O. Chohan et al.   JAMA Neurology

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel

(2017) Amy Akers et al.   NEUROSURGERY

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

A Somatic MAP3K3 Mutation Is Associated with Verrucous Venous Malformation

(2015) Javier A. Couto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prospective Hemorrhage Rates of Cerebral Cavernous Malformations in Children and Adolescents Based on MRI Appearance

(2015) O. Nikoubashman et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

(2015) R. Cuttano et al.   EMBO Molecular Medicine

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

(2015) Oriana S. Fisher et al.   Nature Communications

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

(2014) David A. McDonald et al.   HUMAN MOLECULAR GENETICS

High mutation detection rates in cerebral cavernous malformation upon stringent inclusion criteria: one-third of probands are minors

(2014) Stefanie Spiegler et al.   Molecular Genetics & Genomic Medicine

Native contacts determine protein folding mechanisms in atomistic simulations

(2013) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural history and imaging prevalence of cavernous malformations in children and young adults

(2012) Wajd N. Al-Holou et al.   Journal of Neurosurgery-Pediatrics

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM

(2010) Florence Riant et al.   FEBS Journal

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

(2008) Amy L. Akers et al.   HUMAN MOLECULAR GENETICS

Hemorrhage From Cavernous Malformations of the Brain

(2008) Rustam Al-Shahi Salman et al.   STROKE