Article
Medicine, General & Internal
Kayla R. McCullough, Juheb Akhter, Mauhaun J. Taheri, Amie Traylor, Anna A. Zmijewska, Vivek Verma, Matthew C. Hudson, Abhishek Sachdeva, Elise N. Erman, Kyle H. Moore, James F. George, Subhashini Bolisetty
Summary: This study found that myeloid FtH deficiency was associated with lesser interstitial fibrosis in rhabdomyolysis-induced AKI, despite similar initial injury response to heme burden. Different immune cell populations were abundant in the kidneys during acute and chronic phases, leading to fibrotic remodeling which progressed only in wild-type mice.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Luca Tirinato, Maria Grazia Marafioti, Francesca Pagliari, Jeannette Jansen, Ilenia Aversa, Rachel Hanley, Clelia Nistico, Daniel Garcia-Calderon, Geraldine Genard, Joana Filipa Guerreiro, Francesco Saverio Costanzo, Joao Seco
Summary: The study identified that radioresistant cancer cells in breast, bladder, lung, neuroglioma, and prostate showed an increase in lipid droplet (LD) number, with cells containing higher LDs exhibiting greater clonogenic potential after irradiation. The researchers found a close connection between LD content and iron metabolism, particularly with the presence of the ferritin heavy chain (FTH1). Silencing the FTH1 gene in breast and lung cancer cells reduced LD numbers and increased radiosensitivity, while FTH1 overexpression and iron-chelating treatment restored LD levels and radioresistance.
Article
Medicine, Research & Experimental
Hongjiang Li, Chao Yang, Yanfei Wei, Xueyuan Li, Wei Jiang, Yiran Xu, Lifeng Li, Rongqun Guo, Di Chen, Peng Gao, Haohao Zhang, Hui Qin, Zhenyu Zhang, Xianzhi Liu, Dongming Yan
Summary: Tumor-associated macrophages (TAMs) play a crucial role in immune evasion and immunotherapy resistance of glioblastoma (GBM). The regulatory mechanism of the immunosuppressive tumor microenvironment (TME) of GBM is still unclear.
Article
Nutrition & Dietetics
Minju Kim, Yeon-hee Kim, Sohyun Min, Seung-Min Lee
Summary: This study investigated the potential side effects of high iron levels in fetuses and throughout their adult life. The results suggest that prolonged exposure to high iron may decrease fat accumulation by altering ferritin expression, adipocyte differentiation, and triglyceride metabolism, leading to an alteration in normal growth.
Article
Biochemistry & Molecular Biology
Zilu Cui, Wenkun Li, Yadan Wang, Mengran Zhao, Kuiliang Liu, Yi Yang, Shuo Teng, Nan Zhang, Li Min, Peng Li, Shutian Zhang, Junxuan Xu, Jing Wu
Summary: This study found that the protein level of ferritin heavy chain (FTH1) is upregulated in colon cancer, and M2 macrophages can deliver FTH1 through exosomes to promote colon cancer cell proliferation. These findings provide a new potential therapeutic target for the treatment of colon cancer.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Cell Biology
Bowen Huang, Xiang Zhang, Qin Liu, Changming Bai, Chen Li, Chongming Wang, Lusheng Xin
Summary: In this study, the researchers found that OsHV-1 infection in ark clams can suppress the post-transcriptional translation of SbFn by regulating SbIRP-1, thereby evading host iron limitation.
Article
Chemistry, Multidisciplinary
Jun Wang, Hongye Ding, Yang Zhu, Yina Liu, Meili Yu, Huilan Cai, Rujiang Ao, Hongwei Huang, Peng Gong, Yaxin Liao, Zhaolin Chen, Lisen Lin, Xiaoyuan Chen, Huanghao Yang
Summary: In this study, siRNA-embedded Fe-0 nanoparticles (Fe-0-siRNA NPs) were synthesized for self-reinforcing CDT via FHC downregulation. Upon internalization by cancer cells, pH-responsive Fe-0-siRNA NPs are degraded to release Fe2+ and FHC siRNA, promoting endo/lysosomal escape of siRNA and enhancing CDT through (OH)-O-center dot generation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Medicine, Research & Experimental
Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong, Ji-Min Zhu
Summary: In this study, we found that ferrous iron levels were lower in M2-like TAM compared to M1-like TAM. Loss of iron induced immunosuppressive M2 polarization of mouse macrophages. TFRC, the primary receptor for transferrin-mediated iron uptake, was overexpressed on HCC cells but not TAM. Mechanistically, HCC cells competed with macrophages for iron to upregulate the expression of M2-related genes via induction of HIF-1 alpha, thus contributing to M2-like TAM polarization. Additionally, TFRC is significantly increased in various malignancies, including HCC, and HCC patients with high TFRC levels have considerably shortened overall survival. Furthermore, TFRC is shown to be positively related to tumor-infiltrating M2 macrophages.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Andrew J. Ghio, Matthew Stewart, Rahul G. Sangani, Elizabeth N. Pavlisko, Victor L. Roggli
Summary: Theories on disease pathogenesis following asbestos exposure have emphasized the role of iron. The competition for iron between the host and asbestos leads to functional metal deficiency. The disruption of iron homeostasis activates kinases and transcription factors, resulting in inflammatory and fibrotic responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sara Magri, Beatrice Musca, Laura Pinton, Elena Orecchini, Maria Laura Belladonna, Ciriana Orabona, Camilla Bonaudo, Francesco Volpin, Pietro Ciccarino, Valentina Baro, Alessandro Della Puppa, Susanna Mandruzzato
Summary: This study investigates the immune-suppressive activity of tumor-associated macrophages (TAMs) in the glioblastoma tumor microenvironment (TME). Researchers found that sustained iron metabolism and immune-suppressive activity in TAMs were correlated. They also discovered that blocking the central enzyme heme oxygenase-1 (HO-1) could reverse the tolerogenic activity of TAMs. Additionally, the activation status of T cells affected the expression of PD-L1 and the activity of IDO1, with both being upregulated in the presence of activated T cells. These findings highlight the crucial role of HO-1 in TAMs' immune-suppressive activity and suggest the feasibility of reprogramming TAMs for immune surveillance restoration.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian, Eyad Elkord
Summary: Metabolic dysregulation in the hypoxic tumor microenvironment plays a crucial role in the development of solid tumors, particularly in the metabolic reprogramming of Tregs. This reprogramming can affect the biological properties of Tregs, increasing their presence and proliferation within the TME. Understanding and regulating the metabolism of Tregs may have important implications for the treatment of tumors.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shu Liu, Ying Ying Shen, Li Yang Yin, Jianghua Liu, Xuyu Zu
Summary: In the tumor microenvironment, tumor-associated macrophages (TAMs) and cancer cells have a complex interaction. TAMs can be reprogrammed by tumors, while TAMs also affect the growth of cancer cells. This review focuses on the changes in lipid metabolism between cancer cells and TAMs, providing potential targets for antitumor therapies.
DNA AND CELL BIOLOGY
(2023)
Review
Cell Biology
Ren Xu, Wanning Wang, Wenlong Zhang
Summary: Ferroptosis is a regulated cell death caused by iron-mediated lipid peroxidation. It has been found to be associated with p53, a tumor suppressor protein with multiple functions. P53 acts as a bidirectional regulator of ferroptosis by controlling the metabolism of iron, lipids, glutathione peroxidase 4, reactive oxygen species, and amino acids. A noncanonical pathway of p53 that regulates ferroptosis has also been discovered. These mechanisms have potential clinical applications for treating various diseases.
CELL DEATH DISCOVERY
(2023)
Review
Cell Biology
Lesang Shen, Yunxiang Zhou, Haifei He, Wuzhen Chen, Cameron Lenahan, Xiaoyi Li, Yongchuan Deng, Anwen Shao, Jian Huang
Summary: Leukocytes and iron metabolism play important roles in tumorigenesis, with interplay in the tumor microenvironment. Combining immunotherapy with targeted regulation of iron metabolism may be a future research focus.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Sota Kuno, Hiroaki Fujita, Yu-Ki Tanaka, Yasumitsu Ogra, Kazuhiro Iwai
Summary: NCOA4 acts as a crucial autophagy adaptor protein that regulates ferritin fate under both iron repletion and depletion conditions, maintaining cellular iron homeostasis. By forming insoluble condensates, NCOA4 prevents excessive iron storage in cells and facilitates ferritin delivery to lysosomes, effectively balancing iron levels in the cell.
Article
Pathology
Jingjing Zuo, Zhangwei Hu, Tao Liu, Chen Chen, Zezhang Tao, Shiming Chen, Fen Li
PATHOLOGY RESEARCH AND PRACTICE
(2018)
Article
Oncology
Zhangwei Hu, Lei Wang, Yong Han, Fen Li, Anyuan Zheng, Yong Xu, Fei Wang, Bokui Xiao, Chen Chen, Zezhang Tao
Article
Cell Biology
Zhang-Wei Hu, Yi-Hui Wen, Ren-Qiang Ma, Lin Chen, Xue-Lan Zeng, Wei-Ping Wen, Wei Sun
Summary: The study identified the ferroptosis driver SOCS1 and suppressor FTH1 as independent prognostic factors in head and neck squamous cell carcinoma, correlating with M1 and M2 macrophage infiltration. Targeting ferroptosis-immunomodulation may enhance immunotherapy efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Zhang-Wei Hu, Wei Sun, Yi-Hui Wen, Ren-Qiang Ma, Lin Chen, Wen-Qing Chen, Wen-Bin Lei, Wei-Ping Wen
Summary: CD69 and SBK1 are potential biomarkers to predict response to cancer immunotherapy, guiding treatment decisions for precision therapy.
FRONTIERS IN IMMUNOLOGY
(2022)