Hydrogel matrix presence and composition influence drug responses of encapsulated glioblastoma spheroids

NF-κB inhibitor with Temozolomide results in significant apoptosis in glioblastoma via the NF-κB(p65) and actin cytoskeleton regulatory pathways

(2020) Naze G. Avci et al.   Scientific Reports

A Simple Three-dimensional Hydrogel Platform Enables Ex Vivo Cell Culture of Patient and PDX Tumors for Assaying Their Response to Clinically Relevant Therapies

(2019) Kolin C. Hribar et al.   MOLECULAR CANCER THERAPEUTICS

A novel 3D in vitro model of glioblastoma reveals resistance to temozolomide which was potentiated by hypoxia

(2019) Ahmed Musah-Eroje et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells

(2019) Carlos Velásquez et al.   Journal of Oncology

Predicting Drug Release From Degradable Hydrogels Using Fluorescence Correlation Spectroscopy and Mathematical Modeling

(2019) Saahil Sheth et al.   Frontiers in Bioengineering and Biotechnology

Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel

(2018) Mai T. Ngo et al.   BIOMATERIALS

Comparative Assay of 2D and 3D Cell Culture Models: Proliferation, Gene Expression and Anticancer Drug Response

(2018) Aline G. Souza et al.   CURRENT PHARMACEUTICAL DESIGN

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Hydrogel microenvironments for cancer spheroid growth and drug screening

(2018) Yunfeng Li et al.   Science Advances

Injectable and Cell-Adhesive Polyethylene Glycol Cryogel Scaffolds: Independent Control of Cryogel Microstructure and Composition

(2018) Joseph Bruns et al.   MACROMOLECULAR MATERIALS AND ENGINEERING

Intratumoral Heterogeneity of Glioblastoma Infiltration Revealed by Joint Histogram Analysis of Diffusion Tensor Imaging

(2018) Chao Li et al.   NEUROSURGERY

Cellular and molecular mechanisms of glioblastoma malignancy: implications in resistance and therapeutic strategies

(2018) Joana Balça-Silva et al.   SEMINARS IN CANCER BIOLOGY

Templated Macroporous Polyethylene Glycol Hydrogels for Spheroid and Aggregate Cell Culture

(2018) Mozhdeh Imaninezhad et al.   BIOCONJUGATE CHEMISTRY

The Molecular and Phenotypic Basis of the Glioma Invasive Perivascular Niche

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug Resistance Driven by Cancer Stem Cells and Their Niche

(2017) Marta Prieto-Vila et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

(2017) Gianpiero Lazzari et al.   Polymer Chemistry

Control of gelation, degradation and physical properties of polyethylene glycol hydrogels through the chemical and physical identity of the crosslinker

(2017) Era Jain et al.   Journal of Materials Chemistry B

Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening

(2017) Maria F. Gencoglu et al.   ACS Biomaterials-Science & Engineering

Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening

(2017) Maria F. Gencoglu et al.   ACS Biomaterials Science & Engineering

Apoptotic effect of atorvastatin in glioblastoma spheroids tumor cultured in fibrin gel

(2016) Neda Bayat et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of matrix metalloproteinase-mediated matrix degradation on glioblastoma cell behavior in 3D PEG-based hydrogels

(2016) Christine Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Study of polyethylene glycol-fluorophore complex formation by fluorescence correlation spectroscopy

(2016) Yasaman Chehreghanianzabi et al.   MACROMOLECULAR RESEARCH

The Role of Biomaterials on Cancer Stem Cell Enrichment and Behavior

(2015) Faride Ordikhani et al.   JOM

Glioblastoma multiforme: Pathogenesis and treatment

(2015) Constantinos Alifieris et al.   PHARMACOLOGY & THERAPEUTICS

3D cell culture systems modeling tumor growth determinants in cancer target discovery

(2014) Claudio R. Thoma et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules

(2014) Wei Rao et al.   BIOMATERIALS

A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces

(2014) Andrew D. Rape et al.   BIOMATERIALS

Multilayer Spheroids To Quantify Drug Uptake and Diffusion in 3D

(2014) Toni-Marie Achilli et al.   MOLECULAR PHARMACEUTICS

Bioengineered 3D Brain Tumor Model To Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior Using PEG-Based Hydrogels

(2014) Christine Wang et al.   MOLECULAR PHARMACEUTICS

Invasion as target for therapy of glioblastoma multiforme

(2013) Anne Vehlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation

(2013) Neema Jamshidi et al.   RADIOLOGY

Integrin  5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

(2012) H. Janouskova et al.   CANCER RESEARCH

The multicellular tumor spheroid model for high-throughput cancer drug discovery

(2012) Daniel V LaBarbera et al.   Expert Opinion on Drug Discovery

A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells

(2012) MARIKA A. RUSSO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

Quercetin-induced downregulation of phospholipase D1 inhibits proliferation and invasion in U87 glioma cells

(2011) Mi Hee Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of cell-adhesive peptide ligands on poly(ethylene glycol) hydrogel physical, mechanical and transport properties

(2010) Silviya P. Zustiak et al.   Acta Biomaterialia

Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties

(2010) Silviya P. Zustiak et al.   BIOMACROMOLECULES

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Solute diffusion and interactions in cross-linked poly(ethylene glycol) hydrogels studied by Fluorescence Correlation Spectroscopy

(2010) Silviya P. Zustiak et al.   Soft Matter

HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury

(2010) Aleš Hejčl et al.   STEM CELLS AND DEVELOPMENT

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Mechanical properties of brain tissue by indentation: Interregional variation

(2009) J.A.W. van Dommelen et al.   Journal of the Mechanical Behavior of Biomedical Materials

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE