Article
Medicine, Research & Experimental
Xiao-jie Jiang, Zhi-wei Chen, Jian-feng Zhao, Chang-xi Liao, Qing-he Cai, Jing Lin
Summary: The study investigated the role of cIAP2 in hepatocellular carcinoma, finding that high cIAP2 expression was associated with poor prognosis. Knocking down cIAP2 reduced cell proliferation, invasion, and NF-kappa B pathway activity. Animal experiments showed that cIAP2 knockdown reduced tumourigenicity and proliferation activity in liver cancer cells.
Article
Orthopedics
Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao
Summary: This study reveals that downregulation of Orai1 may reduce cyclin D1 expression by inactivating the Ras-NF-kappa B signaling pathway, thus blocking osteoblast proliferation and cell cycle.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Dan Qi, Jingyuan Lu, Ziyi Fu, Shanshan Lv, Lili Hou
Summary: In this study, psoralen was found to enhance the proliferation, migration, and invasion abilities of trophoblast cells by upregulating the expression and activity of MMP-2 and MMP-9, and promoting the nuclear translocation of NF-κB p65. Psoralen may serve as a potential repurpose drug candidate for inducing trophoblast cell migration and invasion through the NF-κB pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoming Jiang, Zhe Chu, Yang Cao, Ying Tang, Ying Shi, Xu Shi
Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiang-De Li, Qiu-Lu Zhong, Dan-Jing Luo, Qian-fu Liang, Jia-qi Qiu, Qing-Hua Du, Liegang Xiao, Yan-hua Zhou, Yao-Bin Long, Wen-Qi Liu, Jian Li
Summary: The expression of ring finger protein 219 (RNF219) was upregulated in nasopharyngeal carcinoma (NPC) tissues and cells. RNF219 promoted NPC cell invasion, migration, and proliferation by activating the nuclear factor kappa B (NF-kappa B) pathway. Furthermore, RNF219 expression correlated positively with the activity of the NF-kappa B pathway.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang
Summary: The study found that MALT1 is abundant in prostate cancer tissues and can promote NF-kappa B activity in tumor cells, inducing the expression of related genes, and promoting cell proliferation, invasion, and tumor growth.
Article
Genetics & Heredity
Zhen Zhang, Yuan Wei, Xinting Li, Rong Zhao, Xiuli Wang, Ziyi Yang, Ting Li, Xiaozhong Li, Xiaoxia Wang
Summary: This study found that IQGAP1 is highly expressed in esophageal squamous cell carcinoma (ESCC) and is positively correlated with MMP2 expression. IQGAP1 overexpression promotes the growth, migration, and invasion of ESCC cells, upregulates MMP2 expression, and increases NF-kappa B expression and nuclear localization. Treatment with PDTC or JSH-23 can reverse IQGAP1-mediated cell migration and invasion ability, as well as MMP2 expression.
Article
Microbiology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Shin-ichi Miyoshi, Kei Kitahara, Prolay Halder, Hemanta Koley, Mamta Chawla-Sarkar
Summary: This study evaluated the potential of quercetin as an anti-rotavirus therapeutic. Both in vitro and in vivo studies demonstrated that quercetin can effectively inhibit rotavirus replication and infection, and its antiviral activity is independent of interferon. This study provides important evidence for the future use of quercetin as a treatment for rotaviral diarrhea.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Minggang Che, Qing Lan
Summary: RIT1 is upregulated in glioma and associated with poor prognosis. Manipulating RIT1 levels inhibits glioma cell proliferation and invasion. RIT1 contributes to the development and metastasis of glioma via activation of the AKT/ERK/NF-kappa B pathway.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Jing Wang, Tie-Jun Huang, Yan Mei, Fei-Fei Luo, De-Huan Xie, Li-Xia Peng, Bao-Qi Liu, Mei-Ling Fan, Jiang-Bo Zhang, Shu-Tao Zheng, Chao-Nan Qian, Bi-Jun Huang
Summary: This study found that a novel long noncoding RNA LINC02820 is upregulated in ESCC and is associated with the clinical stage of ESCC. Functional experiments showed that LINC02820 specifically promotes migration and invasion capabilities of ESCC cell lines. Mechanistically, it was found that LINC02820 may affect cytoskeletal remodeling, interact with SF3B3, and cooperate with TNFα to amplify the NF-kappa B signaling pathway, leading to ESCC metastasis.
CANCER GENE THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Fangfang Gao, Xiaoqian Mu, Huijuan Wu, Lijuan Chen, Jie Liu, Yanqiu Zhao
Summary: Calreticulin (CALR) is aberrantly expressed in lung cancer, and its overexpression promotes proliferation of lung cancer cells, possibly through activation of the NF-kappa B signaling pathway.
Article
Oncology
Yen-Yun Wang, Amos C. Hung, Steven Lo, Shyng-Shiou F. Yuan
Summary: Obesity is a major modifiable risk factor for breast cancer, with adipocytokines like visfatin and resistin playing important roles in tumor-stromal interactions and breast cancer development. Therapeutic strategies targeting these adipocytokines hold promise for novel breast cancer therapies.
Article
Biochemistry & Molecular Biology
Sirinada Inthanon, Pornngarm Dejkriengkraikul, Supachai Yodkeeree
Summary: This study found that notopterol can inhibit the IL-17-induced proliferation and invasion of A549 lung adenocarcinoma cells by suppressing the activation of the MAPK, Akt, STAT3, AP-1, and NF-kappa B signaling pathways, as well as modulating EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Bingjia Zhao, Qian Zhang, Xiaochun Liang, Jun Xie, Qing Sun
Summary: The study demonstrated that quercetin improved symptoms of diabetic peripheral neuropathy (DPN) in rats, such as mechanical withdrawal threshold, nerve conduction velocity, and pathological changes. Quercetin also exhibited anti-inflammatory effects, possibly mediated through the TLR4/MyD88/NF-kappa B signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingming Jiang, Xihu Yu, Yandong Zhao, Jintuan Huang, Tuoyang Li, Hao Chen, Junyi Zhou, Zhenze Huang, Zuli Yang
Summary: ADAMTS19 suppresses cell migration and invasion by targeting S100A16 via the NF-κB pathway, and the combination of ADAMTS19 and S100A16 provides the optimal prognostic indicator for gastric cancer patients' overall survival.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)