Article
Biochemistry & Molecular Biology
Bo Min Hong, Geum Lan Hong, Min A. Gwak, Kyung Hyun Kim, Jae Eun Jeong, Ju Young Jung, Su A. Park, Won Ho Park
Summary: The new HA-DA hydrogel filler has excellent mechanical properties, biocompatibility, injectability, and can stably adhere to the injection site, potentially overcoming the limitations of commercial fillers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Won-Woo Cho, Byoung Soo Kim, Minjun Ahn, Yeon Hee Ryu, Dong-Heon Ha, Jeong Sik Kong, Jong-Won Rhie, Dong-Woo Cho
Summary: This study introduces a new concept of assembling cell-laden tissue modules for soft tissue engineering, aiming to achieve nonhypoxic, flexible, and volume-stable tissue assembly. The significance of engineered tissue assembly is demonstrated through various evaluations, showing stable volume and significant neovascularization/adipogenesis in the implanted assembly. The work presents a novel approach of cell printing-based tissue assembly for functional reconstruction of soft tissue.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nadja Naenni, Prisca Walter, Christoph H. F. Hammerle, Ronald E. Jung, Daniel S. Thoma
Summary: The study showed that using a cross-linked collagen matrix for soft tissue volume augmentation procedures resulted in higher soft tissue volume, more fibroblast ingrowth, and vascularization compared to non-cross-linked collagen matrix. Additionally, the ridge width was more stable over time in the group using the cross-linked collagen matrix.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Materials Science, Biomaterials
Yichen Dou, Jinhui Huang, Xue Xia, Jiawei Wei, Qin Zou, Yi Zuo, Jidong Li, Yubao Li
Summary: The study developed a hierarchical scaffold for bone repair with a hierarchical pore structure and gradient degradation performance, promoting cell adhesion and proliferation, as well as providing space for bone tissue regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Medicine, Research & Experimental
JiUn Lee, Dongyun Kim, Chul Ho Jang, Geun Hyung Kim
Summary: This study attempted to fabricate a 3D printed scaffold with excellent mechanical properties and recoverable behavior, using human placental extracts as bioactive components. In vitro and in vivo results suggested that the G/H/hPE scaffold is a potential candidate for use in bone tissue engineering.
Article
Medicine, General & Internal
Martina Stefanini, Matteo Sangiorgi, Diego Bianchelli, Pietro Bellone, Federico Gelpi, Daniele De Santis, Giovanni Zucchelli
Summary: This article describes a novel approach that combines muco-gingival, regenerative, and prosthetics concepts for immediate implant insertion. By using specific surgical techniques and materials, this approach allows for soft- and hard-tissue augmentation, resulting in good aesthetic outcomes and high patient satisfaction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jeong Hun Park, Hyun-Ji Park, Sarah Jo Tucker, Sarah R. Rutledge, Lizhen Wang, Michael E. Davis, Scott J. Hollister
Summary: A successful 3D printing of a novel 3D architected auxetic for large-volume soft tissue engineering is reported. The 3D auxetic design is analyzed through finite element (FE) simulation and created by selective laser sintering (SLS) of Poly-epsilon-caprolactone (PCL) for further mechanical and biological analysis. The 3D auxetic exhibits high flexibility and nonlinear stress-strain response, which is achieved despite the relatively stiff and linear properties of PCL. The excellent mechanical and biological performance of the 3D auxetic is attributed to the synergistic effect of its novel design and the printing characteristic of SLS.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Boqing Zhang, Ling Wang, Ping Song, Xuan Pei, Huan Sun, Lina Wu, Changchun Zhou, Kefeng Wang, Yujiang Fan, Xingdong Zhang
Summary: This study successfully combined PLLH/nHA composite with FDM technology to prepare porous bone repair scaffolds. The scaffolds showed good printing smoothness and accuracy, suitable mechanical properties, and good osteogenic properties.
MATERIALS & DESIGN
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zvi Artzi, Uri Renert, Erez Netanely, Daniel S. Thoma, Marilena Vered
Summary: This study examined the composition of lining and masticatory mucosa at implant sites before and after tissue augmentation procedures using VCMX. The results showed that there were increases in mean RPL in both MM and LM areas following augmentation, but no significant differences in RP density or collagen fiber arrangements pre- and post-augmentation. Overall, the augmentation with VCMX did not alter the composition of lining and masticatory mucosa at implant sites.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Materials Science, Composites
Zhiyong Ma, Qifan Wang, Wenjia Xie, Wenjie Ye, Linna Zhong, Jile Huge, Ying Wang
Summary: In this study, a PCL/PLGA/HA scaffold with good pore structure was prepared by 3D printing method. The composite scaffold showed good mechanical and cell test performance, indicating potential applications in the field of bone tissue engineering.
POLYMER COMPOSITES
(2021)
Review
Biochemistry & Molecular Biology
Sven Pantermehl, Steffen Emmert, Aenne Foth, Niels Grabow, Said Alkildani, Rainer Bader, Mike Barbeck, Ole Jung
Summary: The use of additive manufacturing technology in modern medicine is a relatively new field, offering fast and effective ways to produce personalized implants, tissues, and organs for patients. This review provides an overview of various 3D printing technologies, discussing their functions, strengths, and weaknesses in medical applications, as well as summarizing previous studies in tissue engineering.
Article
Dentistry, Oral Surgery & Medicine
Stefan Fickl, Annika Therese Kroger, Thomas Dietrich, Moritz Kebschull
Summary: This systematic review found that soft tissue augmentation procedures inconsistently affected marginal bone level changes, but consistently improved secondary outcomes. The combination of soft and hard tissue augmentation showed better results in terms of marginal soft tissue recession compared to hard tissue augmentation alone. Contour augmentations with soft or hard tissue augmentation resulted in comparable marginal bone level changes.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Theodore J. Puls, Carla S. Fisher, Abigail Cox, Jeannie M. Plantenga, Emma L. McBride, Jennifer L. Anderson, Craig J. Goergen, Melissa Bible, Tracy Moller, Sherry L. Voytik-Harbin
Summary: The collagen filler showed promising results in inducing regenerative healing response in breast conserving surgery, with potential for clinical translation and significant impact on soft tissue restoration and reconstruction needs.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Chaoyi Huang, Xinchao Miao, Jiang Li, Jieyi Liang, Junxi Xu, Zhe Wu
Summary: We developed a novel self-glazed zirconia (SZ) surface with nanotopography and investigated its soft tissue integration capability compared to clinically used titanium and polished conventional zirconia surfaces. The results showed that the SZ surface had a greater protein adsorption ability and promoted the expression of adhesion molecules in cells. In vivo studies demonstrated that the SZ abutment formed strong biological sealing and exhibited more hemidesmosomes. Therefore, the novel SZ surface shows promise for application as a zirconia surface for dental abutments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Crystal S. Shin, Fernando J. Cabrera, Richard Lee, John Kim, Remya Ammassam Veettil, Mahira Zaheer, Aparna Adumbumkulath, Kirti Mhatre, Pulickel M. Ajayan, Steven A. Curley, Bradford G. Scott, Ghanashyam Acharya
Summary: The development of an inflammation modulating biomaterial scaffold for soft tissue repair has shown promising results in inhibiting visceral adhesions formation and minimizing postsurgical complications. In vivo evaluation in a rat ventral hernia model confirmed that the bioscaffold acts as an inflammation trap, capturing proinflammatory cytokines and modulating local inflammation effectively without the need for exogenous anti-inflammatory agents.
ADVANCED MATERIALS
(2021)
Article
Oncology
Seung A. Cheong, Eunhye Kim, Seong-Sung Kwak, Yubyeol Jeon, Sang-Hwan Hyun
MOLECULAR MEDICINE REPORTS
(2015)
Article
Biochemistry & Molecular Biology
So Young Chang, Deu John M. Cruz, Yoonae Ko, Ji-Young Min
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Agriculture, Dairy & Animal Science
Yubyeol Jeon, Yeong-Hee Nam, Seung-A Cheong, Seong-Sung Kwak, Eunsong Lee, Sang-Hwan Hyun
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2016)
Article
Dermatology
Seongsung Kwak, Won-Ho Kang, Chang-Hoon Rhee, Gi-Hyeok Yang, Deu John M. Cruz
DERMATOLOGIC SURGERY
(2020)
Article
Pharmacology & Pharmacy
Hyo-jeong Ryu, Seong-sung Kwak, Chang-hoon Rhee, Gi-hyeok Yang, Hwi-yeol Yun, Won-ho Kang
Summary: This study developed a mathematical kinetic model to explain the change in volume of injected dermal fillers, separating the kinetics of the fillers into hydration, injection-site reaction, and enzyme-mediated degradation. The model was based on a two-compartment system, with one compartment for injection and another for observation of swelling and degradation. The rate-limiting step for complete degradation of the fillers in vivo was found to be the swelling phase, as indicated by the swelling rate constant (K-swell), providing insight for scientists developing new dermal fillers.
Article
Multidisciplinary Sciences
Junhyung Kim, Seongsung Kwak, Mi-Sun Park, Chang-Hoon Rhee, Gi-Hyeok Yang, Jangmi Lee, Woo-Chan Son, Won-ho Kang
Summary: The safety study of replacing HSA with polysorbate 20 as an excipient in BoNT/A products indicated that intramuscular administration of polysorbate 20 is as safe as HSA based on animal experiments, providing a scientific basis for the use of polysorbate 20 as an alternative to HSA.
Article
Dermatology
Min-Seo Choi, Seongsung Kwak, Junhyung Kim, Mi-Sun Park, Soo Min Ko, Taehee Kim, Da Som Jeong, Chang-Hoon Rhee, Gi-Hyeok Yan, Woo-Chan Son, Won-Ho Kang
Summary: This study compared tissue integration of different types of HA dermal fillers and found that fillers from the NEU and BEL series exhibited better inflammatory response and tissue integration compared to the JUV and RES series. Fillers designed for deeper skin layers tended to have slightly higher inflammatory response. The recommended clinical indication and injection depth may influence the local inflammatory response and tissue integration of HA dermal filler products.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Won-Ho Kang, Hyo-Jeong Ryu, Seongsung Kwak, Hwi-Yeol Yun
Summary: This study investigated the anticancer effect of Botulinum Neurotoxin A1 (BoNT/A1) using a syngeneic mouse model transplanted with melanoma cells. A kinetic-pharmacodynamic (K-PD) model was developed to evaluate the quantitative exposure-response relationship. The optimal dose range and regimen were predicted using the model, and confirmed by an in-vivo experiment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jaeyoon Byun, Seongsung Kwak, Jin-Hee Kwon, Minhee Shin, Dong-Kyu Lee, Chang-Hoon Rhee, Won-ho Kang, Jae-Wook Oh, Deu John M. Cruz
Summary: This study compared the pharmacodynamics of three BoNT/A formulations in mice and found that Coretox (R) provided a prolonged duration of action and significant paretic effects after repeated injections.
Article
Immunology
Seongsung Kwak, Ji-Young Lee, Min Ju Kim, Hyo Jin Lee, Dong-Kyu Lee, Jiyeon Kang, Won-ho Kang, Woo-Chan Son, Deu John M. Cruz
Summary: The combination of BoNT/A1 and PD-1 checkpoint blockade shows synergistic antitumor effects in mouse tumor models of melanoma and colon carcinoma, providing evidence for the potential application of BoNT/A1 as an anticancer drug in combination with immune checkpoint blockade.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Article
Biochemical Research Methods
Joana Faria, Carolina B. Moraes, Rita Song, Bruno S. Pascoalino, Nakyung Lee, Jair L. Siqueira-Neto, Deu John M. Cruz, Tanya Parkinson, Jean-Robert Ioset, Anabela Cordeiro-da-Silva, Lucio H. Freitas-Junior
JOURNAL OF BIOMOLECULAR SCREENING
(2015)