Article
Reproductive Biology
Yaping Zhang, Qiqi Li, Wangchang Li, Ke Yan, Yaru Liu, Huiyan Xu, Mingsheng Jiang, Yangqing Lu, Xingwei Liang, Jianghua Shang, Xiaogan Yang
Summary: This study found that 2-Mercaptoethanol (2-ME) can promote in vitro maturation of porcine oocytes by maintaining autophagy homeostasis, leading to improved embryo development.
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mayuko Hashimoto, Shunsuke Kimura, Chihiro Kanno, Yojiro Yanagawa, Takafumi Watanabe, Jun Okabe, Eiki Takahashi, Masashi Nagano, Hiroshi Kitamura
Summary: The study demonstrates the distinct role of the deubiquitinating enzyme USP2 in organ-specific macrophages that directly affect sperm function. Knockout of Usp2 in testicular macrophages led to reduced sperm motility, capacitation, and hyperactivation, as well as decreased levels of intracellular pH, calcium influx, and mitochondrial membrane potential. Administration of GM-CSF restored mitochondrial membrane potential and total sperm motility in mice with macrophage Usp2 deficiency.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jin-Tao Guan, Wei-Jie Wang, Du Jin, Xiao-Yue Mou, Shan-Shan Lei, Zheng-Hao Xu
Summary: This meta-analysis showed that GM-CSF antibody treatment in COVID-19 patients could reduce the risk of death and increase ventilation, without significantly increasing the risk of secondary infection or ICU admission. Older age and length of stay may have an impact on these outcomes.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Immunology
Peilin Chen, Chunyu Huang, Qing Sun, Huixian Zhong, Feng Xiong, Su Liu, Zhihong Yao, Zhiqiang Liu, Caiyun Wan, Yong Zeng, Lianghui Diao
Summary: This study investigated the concentration of GM-CSF in human single-blastocyst conditioned medium (SBCM) and its association with embryo quality and pregnancy outcome. GM-CSF was found to be a potential biomarker for predicting pregnancy outcome and selecting embryos with high developmental potential for transfer in assisted reproductive technology (ART).
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biotechnology & Applied Microbiology
Rui Chen, Yujie Li, Yangyang Zhuang, Yiming Zhang, Hailong Wu, Tao Lin, Shixuan Chen
Summary: This study combines GM-CSF and 3D nanofiber scaffolds to promote tissue regeneration. Through subcutaneous implantation in humanized mice, it was found that GM-CSF could accelerate cell migration and cytokine release, and ultimately enhance tissue regeneration. Therefore, GM-CSF loaded 3D nanofiber scaffolds have potential applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Lan Huang, Guisi Chen, Ying Chen, Wanwen Wu, Changli Tao, Hongwei Shao, Shulin Huang, Han Shen
Summary: Tumor immunotherapy targeting tumor-associated antigens and the impact of GM-CSF and CCL17 on tumor immunity have been widely studied. Combining survivin-specific CTL with CCL17 and GM-CSF genes can inhibit tumor growth more effectively through stable cell lines expressing these genes.
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Plant Sciences
Kewen Ding, Yoshiaki Tabuchi, Toshiaki Makino
Summary: This study investigated the effect of steam processing on the secretion of G-CSF in intestinal epithelial cell-like MCE301 cells. The results showed that steam processing of Panax ginseng root significantly induced G-CSF secretion. The active ingredients in the steamed samples were high-molecular-weight compounds, and the activity was mediated by toll-like receptor (TLR) 9.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ying Jiang, Dan Feng, Chun Wang, Yanlei Zhang, Chuxian Zhao, Su Li, Youwen Qin, Alex H. Chang, Jun Zhu
Summary: This study evaluates the safety and efficacy of GM-CSF intervention post-CAR T-cell therapy in patients with neutropenia and concomitant decline of circulating CAR T-cells. The results show that GM-CSF intervention leads to CAR T-cell expansion and increased levels of white blood cells, neutrophils, lymphocytes, and CD3-CD16 + CD56 + natural killer cells in peripheral blood.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Tempe K. Chen, Jagmohan S. Batra, David E. Michalik, Jacqueline Casillas, Ramesh Patel, Maritza E. Ruiz, Harneet Hara, Bhavita Patel, Meena Kadapakkam, James Ch'Ng, Catherine B. Small, Panagiotis Zagaliotis, Carolyn E. Ragsdale, Luis O. Leal, Emmanuel Roilides, Thomas J. Walsh
Summary: Sargramostim may be a potential adjunctive immunomodulator for selected patients with hematological malignancies and refractory IFDs.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Eunhye Kim, Seon-Ung Hwang, Junchul David Yoon, Eui-Bae Jeung, Eunsong Lee, Dae Young Kim, Sang-Hwan Hyun
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2017)
Article
Reproductive Biology
Junchul David Yoon, Seon-Ung Hwang, Eunhye Kim, Minghui Jin, Soochong Kim, Sang-Hwan Hyun
Article
Reproductive Biology
Seon-Ung Hwang, Kyu-Jun Kim, Eunhye Kim, Junchul David Yoon, Kyu Mi Park, Minghui Jin, Yongquan Han, Mirae Kim, Gabsang Lee, Sang-Hwan Hyun
Article
Veterinary Sciences
Eunhye Kim, Seon-Ung Hwang, Junchul David Yoon, Hyunggee Kim, Gabsang Lee, Sang-Hwan Hyun
BMC VETERINARY RESEARCH
(2018)
Article
Cell Biology
Eunhye Kim, Mirae Kim, Seon-Ung Hwang, Jongpil Kim, Gabsang Lee, Young Seok Park, Sang-Hwan Hyun
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Dermatology
Seongsung Kwak, Won-Ho Kang, Chang-Hoon Rhee, Gi-Hyeok Yang, Deu John M. Cruz
DERMATOLOGIC SURGERY
(2020)
Article
Engineering, Biomedical
Eunhye Kim, Fang Wu, Xuewen Wu, Hyojung J. Choo
Article
Pharmacology & Pharmacy
Hyo-jeong Ryu, Seong-sung Kwak, Chang-hoon Rhee, Gi-hyeok Yang, Hwi-yeol Yun, Won-ho Kang
Summary: This study developed a mathematical kinetic model to explain the change in volume of injected dermal fillers, separating the kinetics of the fillers into hydration, injection-site reaction, and enzyme-mediated degradation. The model was based on a two-compartment system, with one compartment for injection and another for observation of swelling and degradation. The rate-limiting step for complete degradation of the fillers in vivo was found to be the swelling phase, as indicated by the swelling rate constant (K-swell), providing insight for scientists developing new dermal fillers.
Article
Dermatology
Seong Sung Kwak, Kwang Ho Yoon, Jin Hee Kwon, Won-Ho Kang, Chang-Hoon Rhee, Gi-Hyeok Yang, Deu John M. Cruz, Woo-Chan Son
Summary: This study compared the degradation of different types of HA fillers in mice, showing that all seven HA fillers exhibited rapid volume reduction and complete degradation after hyaluronidase injection. There was no significant difference in degradation rate among the fillers, indicating comparable susceptibility to hyaluronidase-mediated degradation.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Junhyung Kim, Seongsung Kwak, Mi-Sun Park, Chang-Hoon Rhee, Gi-Hyeok Yang, Jangmi Lee, Woo-Chan Son, Won-ho Kang
Summary: The safety study of replacing HSA with polysorbate 20 as an excipient in BoNT/A products indicated that intramuscular administration of polysorbate 20 is as safe as HSA based on animal experiments, providing a scientific basis for the use of polysorbate 20 as an alternative to HSA.
Article
Dermatology
Min-Seo Choi, Seongsung Kwak, Junhyung Kim, Mi-Sun Park, Soo Min Ko, Taehee Kim, Da Som Jeong, Chang-Hoon Rhee, Gi-Hyeok Yan, Woo-Chan Son, Won-Ho Kang
Summary: This study compared tissue integration of different types of HA dermal fillers and found that fillers from the NEU and BEL series exhibited better inflammatory response and tissue integration compared to the JUV and RES series. Fillers designed for deeper skin layers tended to have slightly higher inflammatory response. The recommended clinical indication and injection depth may influence the local inflammatory response and tissue integration of HA dermal filler products.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Won-Ho Kang, Hyo-Jeong Ryu, Seongsung Kwak, Hwi-Yeol Yun
Summary: This study investigated the anticancer effect of Botulinum Neurotoxin A1 (BoNT/A1) using a syngeneic mouse model transplanted with melanoma cells. A kinetic-pharmacodynamic (K-PD) model was developed to evaluate the quantitative exposure-response relationship. The optimal dose range and regimen were predicted using the model, and confirmed by an in-vivo experiment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jaeyoon Byun, Seongsung Kwak, Jin-Hee Kwon, Minhee Shin, Dong-Kyu Lee, Chang-Hoon Rhee, Won-ho Kang, Jae-Wook Oh, Deu John M. Cruz
Summary: This study compared the pharmacodynamics of three BoNT/A formulations in mice and found that Coretox (R) provided a prolonged duration of action and significant paretic effects after repeated injections.
Article
Immunology
Seongsung Kwak, Ji-Young Lee, Min Ju Kim, Hyo Jin Lee, Dong-Kyu Lee, Jiyeon Kang, Won-ho Kang, Woo-Chan Son, Deu John M. Cruz
Summary: The combination of BoNT/A1 and PD-1 checkpoint blockade shows synergistic antitumor effects in mouse tumor models of melanoma and colon carcinoma, providing evidence for the potential application of BoNT/A1 as an anticancer drug in combination with immune checkpoint blockade.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Review
Biochemistry & Molecular Biology
Haneul Kim, Gon Sup Kim, Sang-Hwan Hyun, Eunhye Kim
Summary: Neuromuscular diseases involve injury or dysfunction of neuromuscular tissue components. In vitro models have been developed to mimic the complex physical and biochemical microenvironments of human neuromuscular tissues, aiding the study and potential therapies for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)