Pharyngeal Pumping and Tissue-Specific Transgenic P-Glycoprotein Expression Influence Macrocyclic Lactone Susceptibility in Caenorhabditis elegans

Recent advances in functional genomics for parasitic nematodes of mammals

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Biology, Epidemiology, Diagnosis, and Management of Anthelmintic Resistance in Gastrointestinal Nematodes of Livestock

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Comparative study of transcription profiles of the P-glycoprotein transporters of two Haemonchus contortus isolates: susceptible and resistant to ivermectin

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A Whole Genome Re-Sequencing Based GWA Analysis Reveals Candidate Genes Associated with Ivermectin Resistance in Haemonchus contortus

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The P-glycoprotein repertoire of the equine parasitic nematode Parascaris univalens

(2020) Alexander P. Gerhard et al.   Scientific Reports

Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle

(2020) D.M. Leathwick et al.   International Journal for Parasitology-Drugs and Drug Resistance

Detection and quantification of Parascaris P-glycoprotein drug transporter expression with a novel mRNA hybridization technique

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Ivermectin-induced changes in the expression of cytochromes P450 and efflux transporters in Haemonchus contortus female and male adults

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Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

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Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?

(2019) Pablo D. Jimenez Castro et al.   Parasites & Vectors

Motility in the L3 stage is a poor phenotype for detecting and measuring resistance to avermectin/milbemycin drugs in gastrointestinal nematodes of livestock

(2018) Melissa M. George et al.   International Journal for Parasitology-Drugs and Drug Resistance

P-glycoprotein-9 and macrocyclic lactone resistance status in selected strains of the ovine gastrointestinal nematode, Teladorsagia circumcincta

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Comparative genomics of the major parasitic worms

(2018)   NATURE GENETICS

Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device

(2018) Janis C. Weeks et al.   International Journal for Parasitology-Drugs and Drug Resistance

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta

(2017) Young-Jun Choi et al.   PLoS Genetics

P-glycoproteins play a role in ivermectin resistance in cyathostomins

(2017) L.E. Peachey et al.   International Journal for Parasitology-Drugs and Drug Resistance

Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability

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Interaction of macrocyclic lactones with a Dirofilaria immitis P-glycoprotein

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Characterisation of P-glycoprotein-9.1 in Haemonchus contortus

(2016) Pablo Godoy et al.   Parasites & Vectors

Haemonchus contortus P-glycoprotein-2: in situ localisation and characterisation of macrocyclic lactone transport

(2015) Pablo Godoy et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake inCaenorhabditis elegans

(2015) Yiwen Zhou et al.   JOURNAL OF LIPID RESEARCH

Characterization of Haemonchus contortus P-glycoprotein-16 and its interaction with the macrocyclic lactone anthelmintics

(2015) P. Godoy et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis.

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A Customized Light Sheet Microscope to Measure Spatio-Temporal Protein Dynamics in Small Model Organisms

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(2015) Martin K. Nielsen   TRENDS IN PARASITOLOGY

Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels

(2015) Luis Alvarez et al.   VETERINARY PARASITOLOGY

Macrocyclic Lactones Differ in Interaction with Recombinant P-Glycoprotein 9 of the Parasitic Nematode Cylicocylus elongatus and Ketoconazole in a Yeast Growth Assay

(2015) Maximiliane Kaschny et al.   PLoS Pathogens

Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans

(2015) I. Jana I. Janssen et al.   International Journal for Parasitology-Drugs and Drug Resistance

Anthelmintic resistance in equine parasites—Current evidence and knowledge gaps

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Caenorhabditis elegans: Modest increase of susceptibility to ivermectin in individual P-glycoprotein loss-of-function strains

(2013) I. Jana I. Janssen et al.   EXPERIMENTAL PARASITOLOGY

Genetic Variants and Increased Expression of Parascaris equorum P-glycoprotein-11 in Populations with Decreased Ivermectin Susceptibility

(2013) I. Jana I. Janssen et al.   PLoS One

An Extensive Comparison of the Effect of Anthelmintic Classes on Diverse Nematodes

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The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

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The in vitro assay profile of macrocyclic lactone resistance in three species of sheep trichostrongyloids

(2013) Janina Demeler et al.   International Journal for Parasitology-Drugs and Drug Resistance

Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: Influence of the route of administration on the activity against resistant Haemonchus contortus in lambs

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Glutamate-gated Chloride Channels

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Serotonin Activates Overall Feeding by Activating Two Separate Neural Pathways in Caenorhabditis elegans

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Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

(2012) Valentina M. Merola et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin

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Moxidectin and the avermectins: Consanguinity but not identity

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Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression

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Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype

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Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

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Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice

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