Dual regulation of TxNIP by ChREBP and FoxO1 in liver

Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

(2020) Lance A. Thielen et al.   Cell Metabolism

TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis

(2020) Eiji Yoshihara   Antioxidants

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

(2020) Chad N. Brocker et al.   Nature Communications

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

(2018) Mi Jeong Heo et al.   GUT

Insights into the role of hepatocyte PPARα activity in response to fasting

(2018) Marion Régnier et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucocorticoid Upregulates Thioredoxin-interacting Protein in Cultured Neuronal Cells

(2018) Veni Bharti et al.   NEUROSCIENCE

Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP

(2018) Lance Thielen et al.   Current Opinion in Endocrinology Diabetes and Obesity

MondoA/ChREBP: The usual suspects of transcriptional glucose sensing; Implication in pathophysiology

(2017) Paul Richards et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

(2017) Alison Iroz et al.   Cell Reports

MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling

(2016) Byungyong Ahn et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins

(2016) Wenwei Zhang et al.   Cell Reports

Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis

(2015) Blake R Wilde et al.   BRITISH JOURNAL OF CANCER

Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice

(2015) Tatiana Bedarida et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

An Ideal PPAR Response Element Bound to and Activated by PPARα

(2015) John Tzeng et al.   PLoS One

Minireview: Thioredoxin-Interacting Protein: Regulation and Function in the Pancreatic β-Cell

(2014) Anath Shalev   MOLECULAR ENDOCRINOLOGY

Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice

(2013) Seong Ho Jo et al.   DIABETOLOGIA

Induction of the Metabolic Regulator Txnip in Fasting-Induced and Natural Torpor

(2013) Laura E. Hand et al.   ENDOCRINOLOGY

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A potential mechanism of metformin-mediated regulation of glucose homeostasis: Inhibition of Thioredoxin-interacting protein (Txnip) gene expression

(2012) Tin Fan Chai et al.   CELLULAR SIGNALLING

Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death

(2012) E. Reich et al.   DIABETOLOGIA

Glucose Induces Protein Targeting to Glycogen in Hepatocytes by Fructose 2,6-Bisphosphate-Mediated Recruitment of MondoA to the Promoter

(2012) J. L. Petrie et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

(2012) Yukari Ido-Kitamura et al.   PLoS One

Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population

(2011) Noely E. Ferreira et al.   ATHEROSCLEROSIS

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice

(2011) Kebin Zhang et al.   ENDOCRINOLOGY

trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion

(2010) Valérie Nivet-Antoine et al.   BIOCHIMIE

Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic β-cells

(2010) Weijuan Shao et al.   CELLULAR SIGNALLING

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

(2010) Bashayer Mubarak et al.   Channels

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells

(2009) Xiaonan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-independent Regulation of Metabolism by the α-Arrestin Proteins

(2009) Parth Patwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

A Combination of Genomic Approaches Reveals the Role of FOXO1a in Regulating an Oxidative Stress Response Pathway

(2008) Paola de Candia et al.   PLoS One