A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

(2020) Filipa C. Simões et al.   Nature Communications

Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon

(2020) Alessandro Zambusi et al.   Cells

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Progranulin and beta‐catenin in psoriasis: An immunohistochemical study

(2019) Azza Gaber Antar Farag et al.   Journal of Cosmetic Dermatology

Neuroinflammation in frontotemporal dementia

(2019) Fiona Bright et al.   Nature Reviews Neurology

Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish

(2019) Veronika Miskolci et al.   eLife

Improved CUT&RUN chromatin profiling tools

(2019) Michael P Meers et al.   eLife

The lysosomal function of progranulin, a guardian against neurodegeneration

(2018) Daniel H. Paushter et al.   ACTA NEUROPATHOLOGICA

Blood Development: Hematopoietic Stem Cell Dependence and Independence

(2018) Elaine Dzierzak et al.   Cell Stem Cell

Myelopoiesis in the Context of Innate Immunity

(2018) Ioannis Mitroulis et al.   Journal of Innate Immunity

Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo

(2018) Daniel E. Wagner et al.   SCIENCE

Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors

(2018) Daisuke Kurotaki et al.   Cell Reports

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing

(2017) Qin Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progranulin and its biological effects in cancer

(2017) Fabian Arechavaleta-Velasco et al.   MEDICAL ONCOLOGY

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis

(2017) Michael E. Ward et al.   Science Translational Medicine

Tissue-specific contribution of macrophages to wound healing

(2017) Carlos M. Minutti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TNF signaling and macrophages govern fin regeneration in zebrafish larvae

(2017) Mai Nguyen-Chi et al.   Cell Death & Disease

Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization

(2017) Lindsay N. Theodore et al.   Stem Cell Reports

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/β-Catenin Signaling Pathway

(2016) Rong Tian et al.   INFLAMMATION

Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers

(2016) Carolina Alquézar et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

(2016) Andre Olsson et al.   NATURE

Ensembl regulation resources

(2016) Daniel R. Zerbino et al.   Database-The Journal of Biological Databases and Curation

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration

(2015) Ana de la Encarnación et al.   MOLECULAR NEUROBIOLOGY

Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology

(2015) Barbara Solchenberger et al.   PLoS One

Primitive macrophages control HSPC mobilization and definitive haematopoiesis

(2015) Jana Travnickova et al.   Nature Communications

Differential Requirement for irf8 in Formation of Embryonic and Adult Macrophages in Zebrafish

(2015) Celia E. Shiau et al.   PLoS One

Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates

(2014) Q. He et al.   BLOOD

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

Progranulin in neurodegenerative disease

(2014) Terri L. Petkau et al.   TRENDS IN NEUROSCIENCES

Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis

(2014) Silvia Batista et al.   Nature Communications

Assaying hematopoiesis using zebrafish

(2013) Sonja Boatman et al.   BLOOD CELLS MOLECULES AND DISEASES

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Progranulin Protects Vascular Endothelium against Atherosclerotic Inflammatory Reaction via Akt/eNOS and Nuclear Factor-κB Pathways

(2013) Hwan-Jin Hwang et al.   PLoS One

Concise Review: Erythroid Versus Myeloid Lineage Commitment: Regulating the Master Regulators

(2013) Linda Wolff et al.   STEM CELLS

TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3

(2012) R. Espin et al.   Disease Models & Mechanisms

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

(2012) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling

(2012) Jun Seita et al.   PLoS One

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ

(2011) Rui Monteiro et al.   EMBO JOURNAL

Progranulin: A promising therapeutic target for rheumatoid arthritis

(2011) Chuan-ju Liu   FEBS LETTERS

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis

(2010) L. Li et al.   BLOOD

Hematopoietic development in the zebrafish

(2010) Elizabeth J. Paik et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Progranulin A-mediated MET Signaling Is Essential for Liver Morphogenesis in Zebrafish

(2010) Yen-Hsing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

(2010) P Burda et al.   LEUKEMIA

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH