Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction

Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti‐tumor immunity

(2020) Laura M. Sipe et al.   IMMUNOLOGICAL REVIEWS

Liver injury and failure in critical illness

(2019) Thomas Horvatits et al.   HEPATOLOGY

Allocation of Liver Grafts Worldwide Is there a best System?

(2019) Christoph Tschuor et al.   JOURNAL OF HEPATOLOGY

Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

(2019) LB Manna et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

(2018) Qingwen Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Waitlist mortality and post-transplant survival in patients with cholestatic liver disease – Impact of changes in allocation policy

(2018) Katharina Staufer et al.   HPB

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure

(2018) Evangelos Triantafyllou et al.   Frontiers in Immunology

Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

(2018) Julia Leonhardt et al.   Frontiers in Immunology

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

(2017) Evangelos Triantafyllou et al.   GUT

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study

(2017) Vinod S Hegade et al.   LANCET

Circulating bile acids predict outcome in critically ill patients

(2017) Thomas Horvatits et al.   Annals of Intensive Care

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Serum bile acids as marker for acute decompensation and acute-on-chronic liver failure in patients with non-cholestatic cirrhosis

(2016) Thomas Horvatits et al.   LIVER INTERNATIONAL

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules

(2016) Bryan L. Copple et al.   PHARMACOLOGICAL RESEARCH

Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation

(2016) Ashwani K. Singal et al.   TRANSPLANT INTERNATIONAL

Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK

(2015) Christine Bernsmeier et al.   GASTROENTEROLOGY

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

(2014) Alastair J O'Brien et al.   NATURE MEDICINE

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

(2014) Nuruddeen D. Lewis et al.   PLoS One

Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis

(2014) Shinobu Miyazaki-Anzai et al.   PLoS One

Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure

(2013) Charalambos Gustav Antoniades et al.   HEPATOLOGY

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF)

(2013) Juan Cordoba et al.   JOURNAL OF HEPATOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term

(2013) V. Keitel et al.   PLACENTA

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

(2012) Peter Recknagel et al.   PLOS MEDICINE

Profiling Circulating and Urinary Bile Acids in Patients with Biliary Obstruction before and after Biliary Stenting

(2011) Jocelyn Trottier et al.   PLoS One

Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis

(2010) Philip A. Berry et al.   INTENSIVE CARE MEDICINE

Longitudinal monocyte Human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis

(2009) Marie-Luise Berres et al.   LIVER INTERNATIONAL