Article
Oncology
Shizuhide Nakayama, Eisuke Kobayashi, Jun Nishio, Yu Toda, Masaya Yotsukura, Shun-Ichi Watanabe, Takuaki Yamamoto, Akira Kawai
Summary: This study evaluated the prognostic factors and outcomes of pulmonary metastasectomy (PM) for soft tissue sarcomas (STSs) arising in the trunk wall and extremities. The results showed that PM was effective in selected patients, and the disease-free interval, maximum size of metastases, and resectability were identified as prognostic factors.
Article
Oncology
Lina Marie, Dina Braik, Nayef Abdel-Razeq, Hala Abu-Fares, Ahmad Al-Thunaibat, Hikmat Abdel-Razeq
Summary: Breast cancer with de novo bone-only metastasis has distinct clinical features and prognosis compared to subsequent bone-only metastasis. Patients with de novo bone-only metastasis have shorter overall survival.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Xiaofen Li, Wangxiong Hu, Hongna Sun, Hongfeng Gou
Summary: The study investigated the survival outcomes and prognostic factors of patients with synchronous bone metastatic colorectal cancer, identifying seven independent prognostic factors including histological type, differentiation grade, T stage of primary tumor, CEA level, systemic chemotherapy, combined with liver metastasis and combined with lung metastasis. A novel nomogram based on these factors showed good performance in predicting survival outcomes in both internal and external validation.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Oncology
Waseem Masalha, Dieter Henrik Heiland, Christine Steiert, Marie T. Krueger, Daniel Schnell, Christian Scheiwe, Oliver Schnell, Anca-L Grosu, Juergen Beck, Juergen Grauvogel
Summary: The study concluded that gross total resection is the most important prognostic factor for lower recurrence rates and longer progression-free survival in patients with spheno-orbital meningioma. Tumors invading the cavernous sinus and intraconal region showed significantly worse PFS compared to other locations. Postoperative high-precision radiotherapy did not lead to significantly better PFS outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Ofir Ben Gal, Terrence Chi Fang Soh, Sarah Vaughan, Viswanath Jayasanker, Ashish Mahendra, Sanjay Gupta
Summary: Individualized survival prognostic models play a key role in guiding clinical decision-making for orthopedic surgeons, but there is currently no standard model. After evaluating 11 studies, we found that PATHFx 3.0, 2013-SPRING, and OptiModel models performed well in terms of performance.
Article
Orthopedics
Wenhui Wang, Junping Zhen
Summary: This study aimed to construct a new clinical predictive tool to accurately predict the overall survival and cause specific survival of patients with chondrosarcoma receiving different treatments. The study found that age, high malignancy, large tumor, prior chemoradiotherapy, and poor surgical selection were independent risk factors for chondrosarcoma. The established nomogram will help optimize clinicians' personalized decision making.
ORTHOPAEDIC SURGERY
(2023)
Article
Oncology
Ying Ren, Shicheng Wang, Bo Wu, Zhan Wang
Summary: This study aims to uncover the clinicopathological features and identify prognostic risk factors among patients with pancreatic cancer bone metastasis (PCBM). The results show that age, pathological type, chemotherapy, liver metastasis, lung metastasis, and marital status are independent prognostic factors for PCBM patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mickael Tordjman, Charles Honore, Amandine Crombe, Amine Bouhamama, Antoine Feydy, Laurent Dercle, Leila Haddag, Pierre-Alban Bouche, Carine Ngo, Axel Le Cesne, Jean-Yves Blay, Olivier Mir, Mehdi Brahmi, Charlotte Martin, Marie Karanian, Samy Ammari, Michele Kind, Virginie Audard, Francois Le Loarer, Behnam Rabiee, Antoine Italiano, Pascaline Boudou-Rouquette, David Biau, Corinne Balleyguier, Frederique Larousserie, Jean-Luc Drape, Fadila Mihoubi
Summary: This study demonstrated that imaging biomarkers can be used to predict long-term outcome in patients with synovial sarcomas. Strikingly, the presence of calcifications on CT scan is associated with favorable outcome and provides an incremental value over existing prognostic factors such as age, grade, and size.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Alberto Feletti, Alessandro Boaro, Davide Giampiccolo, Giorgio Casoli, Fabio Moscolo, Massimiliano Ferrara, Francesco Sala, Giacomo Pavesi
Summary: The study suggests that most patients with surgically removed spinal hemangioblastomas can expect a good long-term outcome. The neurological outcome of patients with spinal hemangioblastomas is influenced by the preoperative neurological condition.
NEUROSURGICAL REVIEW
(2022)
Article
Surgery
Lea Robin, Alain Sauvanet, Thomas Walter, Haythem Najah, Massimo Falconi, Francois Pattou, Sebastien Gaujoux
Summary: Gastrinoma can be cured by complete resection, but the surgical management for sporadic nonmetastatic gastrinoma is still controversial. This retrospective study analyzed patients who underwent surgery for nonmetastatic sporadic gastrinoma between 2000 and 2020. The study identified predictive factors for overall survival and disease-free survival. The results showed that tumor size and grade were independent predictors of recurrence, and surgical procedures did not significantly affect overall survival and disease-free survival for duodenal gastrinomas.
Article
Multidisciplinary Sciences
Min Jae Seong, Su Jung Choi, Eun Yeon Joo, Young-Min Shon, Dae-Won Seo, Seung Bong Hong, Seung Chyul Hong
Summary: In this study, the long-term surgical outcomes of MR-negative and positive FCD patients were comparable, with no significant difference in seizure-free rates at 2 and 5 years postoperatively. MR-negative FCD patients showed a higher proportion of FCD Type I, and factors such as unilobar cerebral perfusion distribution and concordance of interictal epileptiform discharges were significantly associated with good surgical outcomes in MR-negative FCD.
Article
Medicine, General & Internal
Yu Huang, Chengxin Xie, Qinglong Li, Xiao Huang, Wenwen Huang, Dong Yin
Summary: A prognostic nomogram was constructed to predict the overall survival of patients with bone-metastatic bladder cancer (BMBC) based on data from the Surveillance, Epidemiology, and End Results database. Six independent prognostic factors were identified and included in the nomogram construction. The nomogram showed good predictive accuracy and could serve as a useful tool for predicting overall survival in BMBC patients and guiding treatment decisions.
Article
Oncology
Xiaoshuang Lyu, Bin Luo
Summary: This study analyzed the clinical features and prognostic factors for HER2-positive breast cancer patients with bone metastases, identifying seven prognostic factors for predicting cancer-specific survival. A nomogram was constructed for accurate survival prediction in these patients.
Article
Medicine, General & Internal
Yucheng Wang, Shihong Ren, Xiaokang Gong, Jiacheng Wang, Ning Zhu, Danyang Cai, Jianwei Ruan
Summary: Analyzing melanoma patients with bone metastasis after surgery revealed that smaller tumor size and absence of metastasis at other sites are predictors of survival.
Article
Oncology
Margaret L. Hankins, Clair N. Smith, Beverly Hersh, Tanya Heim, Rebekah Belayneh, Sean Dooley, Adrian Lee, Steffi Oesterreich, Peter C. Lucas, Shannon L. Puhalla, Kurt R. Weiss, Rebecca J. Watters
Summary: The study found that breast cancer patients with de novo bone metastases had a higher mortality rate, while those receiving bone-targeted medical therapy had a lower risk of death. Surgery was commonly used in patients with lytic or mixed tumors, but overall associated with a lower bone metastasis survival rate.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Orthopedics
Masanori Tsubosaka, Hirotsugu Muratsu, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Takao Inokuchi, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto
Summary: This study compared the medial preserving gap technique (MPGT) with the measured resection technique (MRT) in terms of postoperative knee stability after posterior-stabilized total knee arthroplasty (PS-TKA). The results showed that MPGT provided better postoperative medial knee stability, especially at 3 years after PS-TKA.
JOURNAL OF KNEE SURGERY
(2023)
Review
Orthopedics
Kanto Nagai, Kohei Kamada, Jeffrey Kay, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Darren de Sa
Summary: This study aimed to investigate whether the presence of a concomitant Segond fracture affects clinical outcomes after ACL reconstruction and to compare clinical outcomes when a Segond fracture is repaired surgically or left unrepaired. The results showed that an unrepaired Segond fracture does not appear to have any significant negative effect on postoperative stability or risk of graft failure or revision surgery after ACL reconstruction.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Yoshinori Takashima, Tomoyuki Matsumoto, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda
Summary: The study aimed to investigate whether the transplantation of human cells from a non-reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon-bone healing. The results showed that the non-reattachment group exhibited higher and earlier healing, with induction of endochondral ossification-like integration and mature bone ingrowth. This enhanced healing potential was attributed to increased intrinsic angiogenesis/osteogenesis. In comparison, the reattachment group showed poorer tendon-bone healing.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Clinical Neurology
Yasutaka Nikaido, Hideyuki Urakami, Yohei Okada, Toshihiro Akisue, Yuki Kawami, Naoya Ishida, Yoshinaga Kajimoto, Ryuichi Saura
Summary: This study evaluated the rehabilitation effects of dynamic equilibrium gait training (DEGT) for patients with idiopathic normal pressure hydrocephalus (iNPH) who underwent cerebrospinal fluid (CSF) shunting, compared to standard exercise (SE) and no further treatment. The results showed that DEGT can improve gait-balance functions and reduce the fall incidence of iNPH patients after CSF shunting.
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Yoichi Shimizu, Kento Masukawa, Maho Aoyama, Tatsuya Morita, Yoshiyuki Kizawa, Satoru Tsuneto, Yasuo Shima, Mitsunori Miyashita
Summary: This study investigated the impact of stressful life events on depression and grief among bereaved family members of cancer patients. The results showed that most family members experienced significant distress when facing difficulties in daily life and social isolation, and this distress was associated with increased risks of depression and complicated grief. Therefore, assessing risk factors and enhancing readiness to adapt to post-bereavement life changes are important.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Oncology
Kazuma Iwashita, Hikaru Kubota, Riku Nishioka, Yuki Emoto, Daisuki Kawahara, Takeaki Ishihara, Daisuke Miyawaki, Ikuno Nishibuchi, Yasushi Nagata, Ryohei Sasaki
Summary: This study aimed to construct a prognostic survival model for esophageal cancer patients who underwent radical irradiation using skeletal muscle radiomics. The predictive model constructed by machine learning and LASSO algorithm showed good performance in predicting the survival of esophageal cancer patients, with high accuracy, specificity, sensitivity, and area under the concentration-time curve.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Kazuhiro Kitajima, Junpei Kuyama, Takashi Kawahara, Tsuyoshi Suga, Tomoaki Otani, Shigeyasu Sugawara, Yumiko Kono, Yukihisa Tamaki, Ayumi Seko-Nitta, Yoshinobu Ishiwata, Kimiteru Ito, Akira Toriihara, Shiro Watanabe, Makoto Hosono, Hideaki Miyake, Shingo Yamamoto, Ryohei Sasaki, Mitsuhiro Narita, Koichiro Yamakado
Summary: This retrospective study investigated the efficacy of change in the automated bone scan index (aBSI) as an imaging biomarker for treatment response and survival prediction in mCRPC patients treated with Ra-223. The study analyzed data from 205 Japanese mCRPC patients who received Ra-223 treatment between July 2016 and August 2020. The results showed that changes in aBSI, alkaline phosphatase (ALP), and prostate-specific antigen (PSA) were significant prognostic factors for overall survival in these patients.
Article
Medicine, General & Internal
Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Kunihiko Miyazaki, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Teruya Kawamoto, Hitomi Hara, Yuichi Hoshino, Shinya Hayashi, Toshihiro Akisue, Ryosuke Kuroda
Summary: The number of advanced-age patients with spinal metastases is increasing. This study aimed to analyze the characteristics and outcomes of spinal metastases surgery in advanced-age patients. Prospective analysis of 216 patients divided into three age groups showed that patients aged ≥80 years had poorer performance status, Barthel index, and EQ-5D before and after surgery. Postoperative complications and EQ-5D re-deterioration rates were higher in the ≥80-year group. While surgery improved outcomes regardless of age, clinicians should consider the poorer outcomes and higher complication rates in advanced-age patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Kensuke Anjiki, Tomoyuki Matsumoto, Yuichi Kuroda, Masahiro Fujita, Shinya Hayashi, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Kenichi Kikuchi, Kenmei Ikuta, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takehiko Matsushita, Ryosuke Kuroda
Summary: This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit stromal-vascular fraction (SVF) on rabbit chondrocytes. It was found that the SVF group showed superior therapeutic effects compared to the low-dose adipose-derived stromal cells (lADSC) group. The SVF group mainly consisted of M2 macrophages, which secreted growth factors and chondrocyte-protective cytokines, benefiting chondrocytes and knee joint homeostasis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Masahiro Fujita, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda
Summary: This study aimed to compare the clinical and radiological outcomes of single and double stromal vascular fraction (SVF) cell injections in patients with knee osteoarthritis (OA). The results showed that the total WOMAC score improved significantly in the single injection group from 3 to 24 months, while the double injection group showed significant improvement at 24 months. In conclusion, double injections may provide better treatment outcomes for patients with severe varus knee alignment.
CELL TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Takahiro Furukawa, Takashi Kurosawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Yasuhiro Ueda, Takeshi Kataoka, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda
Summary: This study aims to evaluate the in vitro effects of apocynin on human rotator cuff-derived cells. The results showed that apocynin can effectively reduce AGE-induced oxidative stress by inhibiting NOX activation. Thus, apocynin is a potential prodrug in preventing degenerative changes of the rotor cuff.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Oncology
Rai Shimoyama, Yoshinori Imamura, Kiyoaki Uryu, Takahiro Mase, Masataka Taguri, Tadahisa Okuda, Yoshiaki Fujimura, Maki Hayashi, Satomi Tanaka, Keiji Sawamukai, Hironobu Minami
Summary: Our real-world data analysis confirmed widespread use of standard care throughout Japan and survival benefits of combination therapy over monotherapy in treating metastatic biliary tract cancer.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Koji Nukuto, Takehiko Matsushita, Kohei Kamada, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda
Summary: This study successfully developed the first MMPRT mouse model, which can be used to investigate the pathological changes of MMPRT.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Orthopedics
Kohei Kamada, Takehiko Matsushita, Kanto Nagai, Yuichi Hoshino, Daisuke Araki, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda
Summary: This study comprehensively evaluated the risk factors of residual pivot-shift after anatomic double-bundle ACL reconstruction. The results showed that patients younger than 20 years of age, with high-grade preoperative pivot-shift, or hyperextended knees had a higher risk of residual postoperative pivot-shift.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
