Article
Immunology
Manivel Rengasamy, Anna Marsland, Lora McClain, Tessa Kovats, Thomas Walko, Lisa Pan, Rebecca B. Price
Summary: The study found that in adolescents receiving standard-of-care community treatment, TNF alpha levels were positively correlated with depression severity and anhedonia symptoms, with higher baseline TNF alpha levels predicting more severe depression symptoms in the future. However, no association was found between changes in clinical measures and changes in cytokine levels over time.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Chemistry, Medicinal
Ravi Ranjan Kumar, Bhaskar Sahu, Shelly Pathania, Pankaj Kumar Singh, M. Jawaid Akhtar, Bhupinder Kumar
Summary: Depression is a major cause of global disability, with many antidepressant drugs on the market containing a piperazine substructure. Piperazine plays a significant role in the development of novel antidepressants, contributing to their design and development.
Article
Endocrinology & Metabolism
Manivel Rengasamy, Anna Marsland, Lora McClain, Tessa Kovats, Thomas Walko, Lisa Pan, Rebecca B. Price
Summary: This study found a positive association between childhood trauma, particularly emotional abuse, and elevated levels of the proinflammatory cytokine TNF alpha in depressed adolescents. However, no longitudinal relationship was found between childhood trauma and cytokine levels. These findings suggest that childhood trauma may contribute to heterogeneity in cytokine elevation among depressed adolescents.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bhaskar Sahu, Rohit Bhatia, Dilpreet Kaur, Diksha Choudhary, Ravi Rawat, Shilpa Sharma, Bhupinder Kumar
Summary: Piperazine derivatives have been synthesized and tested for their MAO inhibitory activity. Compound 5f and 5g showed the strongest potential as MAO-A inhibitors with IC50 values of 0.96 and 0.81 mu M, respectively. These compounds exhibited reversible inhibition of MAO-A without cytotoxicity and displayed good antioxidant activity. In vivo studies demonstrated their antidepressant-like activity. Molecular docking and dynamic studies confirmed the stable complex formation between these compounds and the MAO-A enzyme. These findings suggest that the piperazine clubbed oxadiazole structural framework is a promising target for developing new antidepressant molecules.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Marta Kubera, Beatriz Arteta, Beata Grygier, Katarzyna Curzytek, Stanislaw Malicki, Michael Maes
Summary: This study found that fluoxetine and desipramine can increase the number and volume of liver metastases, while mirtazapine does not have this effect. Additionally, fluoxetine and desipramine can suppress immune defense response, unlike mirtazapine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mala Singh, Mohmmad Shoab Mansuri, Ashlesha Kadam, Sayantani P. Palit, Mitesh Dwivedi, Naresh C. Laddha, Rasheedunnisa Begum
Summary: TNF-alpha levels were found to be increased in vitiligo patients, impacting melanocyte biology. Stimulation with TNF-alpha resulted in reduced cell viability, increased cellular and mitochondrial ROS, and compromised complex I activity in melanocytes. TNF-alpha exposure also led to cell apoptosis and autophagy, indicating a functional link between autophagy and melanocyte destruction in autoimmune vitiligo pathogenesis.
Article
Immunology
Yuan You, Patrick Stelzl, Dana N. Joseph, Paulomi B. Aldo, Anthony J. Maxwell, Nava Dekel, Aihua Liao, Shannon Whirledge, Gil Mor
Summary: In this study, a 3D in vitro model was used to investigate the interaction between trophoblasts and human endometrial stroma cells, demonstrating how stromal factors promote trophoblast invasion in an inflammatory environment modulated by TNF-alpha. Additionally, stromal-derived IL-17 was found to play a role in promoting trophoblast migration by inducing essential genes for invasive capacity. These findings provide new insights into the complex process of implantation and highlight the importance of inflammation in embryo implantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Sport Sciences
Grace L. Rose, Tina L. Skinner, Gregore Mielke, Mia A. Schaumberg
Summary: The study found that exercise intensity did not significantly influence chronic inflammatory response overall, but higher-intensity exercise may be more effective than lower-intensity exercise for middle-aged adults or in longer duration interventions.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Review
Medicine, General & Internal
Milena Akamatsu, Tavares de Castro, Carolina Yumi Takano, Paulo Lee Ho
Summary: Interferons play crucial roles in immune responses, especially in viral infections. Cytokine storms are exaggerated physiological reactions triggered by pathogens, which can lead to severe tissue damage and organ failure.
Article
Cell Biology
Fang Jia, Gang Wang, Jing Xu, Junhong Long, Fuxue Deng, Wei Jiang
Summary: The study suggests that cytokine levels are associated with the mortality risk of patients with severe or critical COVID-19, with TNF-alpha identified as one of the risk factors for patient death. Anti-TNF-alpha treatment may help patients with severe or critical COVID-19 pneumonia recover.
Review
Chemistry, Medicinal
Alvaro Nobrega de Melo Madureira, Joao Ricardhis Saturnino de Oliveira, Vera Lucia de Menezes Lima
Summary: Interleulcin-6 (IL-6) is a myokine that can be released by exercising skeletal muscle. It activates the PI3K-Akt pathway to enhance insulin signaling and glycogen synthesis. IL-6 also increases GLUT-4 vesicle mobilization and may contribute to muscle hypertrophy by activating mTORC1 and promoting contractile protein synthesis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Parnian Shobeiri, Homa Seyedmirzaei, Nastaran Karimi, Fatemeh Rashidi, Antonio L. Teixeira, Serge Brand, Dena Sadeghi-Bahmani, Nima Rezaei
Summary: Physical exercise has a positive impact on the mental well-being of people with multiple sclerosis (PwMS). However, exercise does not result in significant changes in IL-6 levels in PwMS, unlike the response observed in healthy subjects and other medical contexts. Regular exercise, on the other hand, has a specific anti-inflammatory effect on blood TNF-alpha levels in PwMS.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Psychiatry
Qiang Wang, Lingyun Zeng, Wenjuan Hong, Mingying Luo, Nan Zhao, Xiaofen Hu, Meili Shi, Jing Qiu, Yanmin Shen, Xiuju Teng, Haiying Min, Weiqing Liu
Summary: This study aimed to explore the changes in inflammatory cytokine levels in patients with depression after 4 weeks of rTMS treatment. The results revealed that the changes in inflammatory cytokines after rTMS treatment showed different patterns compared to the sham group, suggesting that the antidepressant effect of rTMS may be related to changes in inflammatory cytokines.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Veterinary Sciences
Diego Romario-Silva, Josy Goldoni Lazarini, Marcelo Franchin, Severino Matias de Alencar, Pedro Luiz Rosalen
Summary: The study found that Brazilian organic honey, especially the OH-7 variety, has promising anti-inflammatory potential. These organic honey varieties may contribute to the development of new products and be used in veterinary medicine and human health.
VETERINARY SCIENCES
(2022)
Article
Behavioral Sciences
Sana Tafseer, Rachna Gupta, Rafat Ahmad, Seema Jain, M. S. Bhatia, Lalit K. Gupta
Summary: This study found that bupropion SR monotherapy is effective and well tolerated in patients with moderate to severe depression, and its therapeutic efficacy is associated with an increase in serum BDNF levels and a decrease in serum TNF-alpha levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Paula Berman, Kate Futoran, Gil M. Lewitus, Dzmitry Mukha, Maya Benami, Tomer Shlomi, David Meiri
SCIENTIFIC REPORTS
(2018)
Article
Nanoscience & Nanotechnology
Almog Uziel, Anat Gelfand, Keren Amsalem, Paula Berman, Gil M. Lewitus, David Meiri, Dan Y. Lewitus
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Neurosciences
Amanda L. Hanes, Andrew G. Koesters, Ming-fai Fong, Haider F. Altimimi, David Stellwagen, Peter Wenner, Kathrin L. Engisch
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Joshua Aviram, Yelena Vysotski, Paula Berman, Gil M. Lewitus, Elon Eisenberg, David Meiri
Article
Oncology
Gil Bar-Sela, Idan Cohen, Salvatore Campisi-Pinto, Gil M. Lewitus, Lanuel Oz-Ari, Ayellet Jehassi, Avivit Peer, Ilit Turgeman, Olga Vernicova, Paula Berman, Mira Wollner, Mor Moskovitz, David Meiri
Article
Chemistry, Medicinal
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Anton Uribayev, Shiri Procaccia, Idan Cohen, Anca Leibovici, Mahmud Abo-Amna, Luiza Akria, Dmitry Goncharov, Neomi Mativ, Avia Kauffman, Ayelet Shai, Or Hazan, Gil Bar-Sela, David Meiri
Article
Pharmacology & Pharmacy
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Ben Yellin, Paula Berman, Anna Shapira, David Meiri
Summary: During prolonged medical cannabis treatment for chronic non-cancer pain, pain intensities remained stable while analgesic medication consumption decreased and quality of life improved. The consumption rates of high dose THC and alpha-pinene increased during the treatment period.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Paula Berman, Anna Shapira, Shiri Procaccia, David Meiri
Summary: Studies have shown that women are more susceptible to adverse effects from conventional drugs. This study aimed to investigate the differences of medical cannabis-related adverse effects between women and men in patients with chronic noncancer pain. The results showed that women reported more medical cannabis-related adverse effects, possibly due to both the inherent sex effect and the consumption of specific phytocannabinoid compositions.
Article
Pharmacology & Pharmacy
Joshua Aviram, Gil M. Lewitus, Dorit Pud, Shiri Procaccia, Paula Berman, Ben Yellin, Yelena Vysotski, Or Hazan, Elon Eisenberg, David Meiri
Summary: This study aimed to identify patterns of phytocannabinoid compositions associated with medical cannabis treatment response and associated adverse effects. Ten clusters with similar analgesic treatment response rates were identified, but significant differences in adverse effects rates were found at short- and long-term. Specific phytocannabinoid compositions were linked to overall adverse effects rates and specific adverse effects rates, highlighting the need for comprehensive profiling of phytocannabinoids to help physicians prescribe safer cannabis for pain relief.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Shiri Procaccia, Gil Moshe Lewitus, Carni Lipson Feder, Anna Shapira, Paula Berman, David Meiri
Summary: Medical cannabis and its major components THC and CBD are gaining popularity for various medical purposes, but studies regarding their efficacy are inconclusive due to the versatile nature of the cannabis plant and the interplay between its compounds and the endocannabinoid system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gina M. Kemp, Haider F. Altimimi, Yoonmi Nho, Renu Heir, Adam Klyczek, David Stellwagen
Summary: Acute stress induces synaptic plasticity and behavioral changes in the brain. The study reveals that TNF is a crucial mediator in the stress response of mice, required for stress-induced synaptic potentiation and increased anxiety-like behavior. The activation of microglia leads to the long-term release of TNF, while sustained TNF signaling in the ventral hippocampus is necessary for maintaining the stress-induced changes.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Julien Chambon, Pragya Komal, Gil M. Lewitus, Gina M. Kemp, Simone Valade, Houaria Adaidi, Noura Al Bistami, David Stellwagen
Summary: Huntington's disease (HD) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin gene. Neurodegeneration in HD first occurs in the striatum, accompanied by an elevation in inflammatory cytokines. In a mouse model of HD, early changes in synaptic input onto striatal medium spiny neurons were observed, including an increase in excitatory synaptic strength and a decrease in inhibitory synaptic strength, which are both dependent on the pro-inflammatory cytokine tumor necrosis factor alpha (TNF) signaling. These changes may contribute to the development of excitotoxicity during the progress of HD.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Mahmoud Abu Amna, Anton Ouryvaev, Shiri Procaccia, Idan Cohen, Anca Leibovici, Luiza Akria, Dimitry Goncharov, Neomi Mativ, Avia Kauffman, Ayelet Shai, Gil Bar-Sela, David Meiri
Summary: The use of medical cannabis to treat cancer-related symptoms is increasing. This study prospectively followed up on the effectiveness and safety of medical cannabis treatment in oncology patients. The results showed that most patients experienced significant improvement in symptoms during medical cannabis treatment, with common but non-serious adverse effects.
FRONTIERS IN PAIN RESEARCH
(2022)
Article
Chemistry, Analytical
Paula Berman, Liron Sulimani, Anat Gelfand, Keren Amsalem, Gil M. Lewitus, David Meiri
Article
Medicine, General & Internal
Jeffrey Y. Hergenrather, Joshua Aviram, Yelena Vysotski, Salvatore Campisi-Pinto, Gil M. Lewitus, David Meiri
RAMBAM MAIMONIDES MEDICAL JOURNAL
(2020)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
