A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts

Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15

(2020) Diego Arauna et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physical activity and exercise: Strategies to manage frailty

(2020) Javier Angulo et al.   Redox Biology

Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study

(2020) Riccardo Calvani et al.   GeroScience

Subtypes of physical frailty and their long‐term outcomes: a longitudinal cohort study

(2020) Shih‐Tsung Huang et al.   Journal of Cachexia Sarcopenia and Muscle

Frailty Parameters, Morbidity and Mortality in Older Adults with Cancer: A Structural Equation Modelling Approach Based on the Fried Phenotype

(2020) Frederic Pamoukdjian et al.   Journal of Clinical Medicine

Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus

(2019) Leocadio Rodriguez‐Mañas et al.   Journal of Cachexia Sarcopenia and Muscle

Increased levels of soluble Receptor for Advanced Glycation End-products (RAGE) are associated with a higher risk of mortality in frail older adults

(2019) Lee Butcher et al.   AGE AND AGEING

Altered immune system in frailty: Genetics and diet may influence inflammation

(2019) Orietta Pansarasa et al.   AGEING RESEARCH REVIEWS

Associations of fat‐soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative

(2019) Bastian Kochlik et al.   Journal of Cachexia Sarcopenia and Muscle

Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty

(2019) Nicholas J. W. Rattray et al.   Nature Communications

Effect of Physical Activity on Frailty

(2018) Andrea Trombetti et al.   ANNALS OF INTERNAL MEDICINE

Relationship Between Sarcopenia and Frailty in the Toledo Study of Healthy Aging: A Population Based Cross-Sectional Study

(2018) B. Davies et al.   Journal of the American Medical Directors Association

Is there any evidence that AGE/sRAGE is a universal biomarker/risk marker for diseases?

(2018) Kailash Prasad   MOLECULAR AND CELLULAR BIOCHEMISTRY

Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries: a systematic review and meta-analysis

(2018) Dhammika D Siriwardhana et al.   BMJ Open

Frailty and the endocrine system

(2018) Andrew Clegg et al.   Lancet Diabetes & Endocrinology

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

(2018) Jamie N. Justice et al.   GeroScience

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

(2018) Siranjeevi Nagaraj et al.   AGEING RESEARCH REVIEWS

Feature Selection with the R Package MXM: Discovering Statistically Equivalent Feature Subsets

(2017) Vincenzo Lagani et al.   Journal of Statistical Software

Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging

(2017) Mariam El Assar et al.   Journal of the American Medical Directors Association

An NPPB Promoter Polymorphism Associated With Elevated N‐Terminal pro–B‐Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality

(2017) Sara B. Seidelmann et al.   Journal of the American Heart Association

Subtypes of physical frailty: Latent class analysis and associations with clinical characteristics and outcomes

(2017) Li-Kuo Liu et al.   Scientific Reports

Factors Influencing Transitions Between Frailty States in Elderly Adults: The Progetto Veneto Anziani Longitudinal Study

(2016) Caterina Trevisan et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function

(2016) Jose Viña et al.   MOLECULAR ASPECTS OF MEDICINE

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

(2016) Javier Angulo et al.   MOLECULAR ASPECTS OF MEDICINE

Serial measurement of N-terminal pro–B-type natriuretic peptide and cardiac troponin T for cardiovascular disease risk assessment in the Multi-Ethnic Study of Atherosclerosis (MESA)

(2015) Lori B. Daniels et al.   AMERICAN HEART JOURNAL

Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative

(2015) Giuseppe Lippi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

In Search of ‘Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative

(2015) Jorge D. Erusalimsky et al.   GERONTOLOGY

Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain

(2015) Marit Kristine Smedsrud et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Correlation of the plasma levels of soluble RAGE and endogenous secretory RAGE with oxidative stress in pre-diabetic patients

(2015) Minglian Huang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

mice: Multivariate Imputation by Chained Equations inR

(2015) Stef van Buuren et al.   Journal of Statistical Software

Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging

(2013) Cristina Alonso-Bouzón et al.   AGE

sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death

(2013) E. Selvin et al.   DIABETES

Frailty in elderly people

(2013) Andrew Clegg et al.   LANCET

Health and aging in elderly farmers: the AMI cohort

(2012) Karine Pérès et al.   BMC PUBLIC HEALTH

Prevalence of Frailty in Community-Dwelling Older Persons: A Systematic Review

(2012) Rose M. Collard et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project

(2012) Leocadio Rodríguez-Mañas et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Endogenous Cardiac Troponin T Modulates Ca2+-Mediated Smooth Muscle Contraction

(2012) Shunichi Kajioka et al.   Scientific Reports

Total Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products as Predictive Biomarkers of Coronary Heart Disease Risk in Patients With Type 2 Diabetes: An Analysis From the CARDS Trial

(2011) H. M. Colhoun et al.   DIABETES

The prevalence of frailty syndrome in an older population from Spain. The Toledo study for healthy aging

(2011) Francisco José Garcia-Garcia et al.   Journal of Nutrition Health & Aging

Frailty Among Community-Dwelling Elderly People in France: The Three-City Study

(2011) J. A. Avila-Funes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Risk factors for disability in older persons over 3-year follow-up

(2009) D. Balzi et al.   AGE AND AGEING

On reliable discovery of molecular signatures

(2009) Roland Nilsson et al.   BMC BIOINFORMATICS

Computational disease modeling – fact or fiction?

(2009) Jesper N Tegnér et al.   BMC Systems Biology

MicroRNA regulates human vitamin D receptor

(2009) Takuya Mohri et al.   INTERNATIONAL JOURNAL OF CANCER

Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment

(2009) L. P. Fried et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A standard procedure for creating a frailty index

(2008) Samuel D Searle et al.   BMC Geriatrics