Article
Endocrinology & Metabolism
Ruziana Mona Wan Mohd Zin, Muhammad Yazid Jalaludin, Abqariyah Yahya, Ahmad Kamil Nur Zati Iwani, Fuziah Md Zain, Janet Yeow Hua Hong, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud
Summary: This study aimed to compare several parameters related to obesity between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) children, and to examine the predictors associated with the MHO phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Jae-Uk Song, Jonghoo Lee, Si-Young Lim, Hyun-Il Gil, Yoosoo Chang, Seungho Ryu
Summary: This study investigated the association between metabolically healthy and unhealthy obesity and incident lung dysfunction. The results showed that both metabolically healthy and unhealthy obesity were positively associated with restrictive pattern lung dysfunction, with a stronger association in the unhealthy obesity group. However, obesity was inversely associated with obstructive pattern lung dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ozra Tabatabaei-Malazy, Sahar Saeedi Moghaddam, Masoud Masinaei, Nazila Rezaei, Sahar Mohammadi Fateh, Arezou Dilmaghani-Marand, Elham Abdolhamidi, Farideh Razi, Patricia Khashayar, Alireza Mahdavihezaveh, Siamak Mirab Samiee, Bagher Larijani, Farshad Farzadfar
Summary: The prevalence of metabolically healthy obesity (MHO) and metabolic unhealthiness in obese individuals was 7.5% and 18.3% respectively. Factors such as low physical activity, urban residence, and higher education were associated with metabolic unhealthiness. Dyslipidemia was the most common component of MetS among different weight categories.
Article
Multidisciplinary Sciences
Jae-Min Park, Da-Hyun Park, Youhyun Song, Jung Oh Kim, Ja-Eun Choi, Yu-Jin Kwon, Seong-Jin Kim, Ji-Won Lee, Kyung-Won Hong
Summary: This study identified genetic indices associated with metabolically unhealthy normal weight and healthy obese phenotypes using GWAS in a Korean population. The genes related to unhealthy phenotypes in normal weight individuals were linked to insulin or glucose metabolism, while those in obese individuals were more involved in lipid metabolism. These findings could help identify individuals at high metabolic risk and provide new targets for managing unhealthy phenotypes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Peter Piko, Erand Llanaj, Karoly Nagy, Roza Adany
Summary: This study identified a cluster of SNPs that contribute to the development of the metabolically unhealthy phenotype in Hungarian adults suffering from obesity, emphasizing the significance of considering the combined effect(s) of multiple genes and SNPs in assessing cardiometabolic risk in obesity in future genetic screening programs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Victor M. Oguoma, Mohamed Abu-Farha, Neil T. Coffee, Saad Alsharrah, Faisal H. Al-Refaei, Jehad Abubaker, Mark Daniel, Fahd Al-Mulla
Summary: Obesity is a major public health crisis in Kuwait. This study examines the prevalence of metabolically healthy obese (MHO) phenotype and its relationship with inflammation markers, liver function, and insulin resistance in Arab and South Asian ethnic groups. The results show a high prevalence of MHO in Kuwait.
Article
Endocrinology & Metabolism
Shan Cai, Jiajia Dang, Panliang Zhong, Ning Ma, Yunfei Liu, Di Shi, Zhiyong Zou, Yanhui Dong, Jun Ma, Yi Song
Summary: This study analyzed the sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents in China. The results showed higher prevalence of obesity phenotypes in boys and identified various risk factors such as parental smoking, birth weight, and lifestyle factors. The findings highlight the importance of considering sex differences in managing obesity phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marica Meroni, Federica Chiappori, Erika Paolini, Miriam Longo, Emilia De Caro, Ettore Mosca, Alice Chiodi, Ivan Merelli, Sara Badiali, Marco Maggioni, Alessandra Mezzelani, Luca Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni
Summary: Visceral adipose tissue (VAT) plays a role in metabolic dysfunction-associated steatotic liver disease (MASLD) by releasing lipogenic substrates and cytokines that promote inflammation. This study aimed to identify shared dysfunctional pathways and transcriptomic signatures between the liver and VAT in individuals transitioning from metabolic healthy obese (MHO) to unhealthy (MUHO), who develop MASLD. RNA-sequencing was performed on liver and VAT samples from MHO and MUHO individuals. The study identified a transcriptomic signature that distinguishes MUHO from MHO, with several deregulated genes and downregulated pathways, including oxidative phosphorylation. The study also identified 5 commonly deregulated genes in both liver and VAT and built a tissue-related score based on their expressions. Serum levels of C6 and IGF1, the only secreted proteins among the gene signature, were found to be downregulated in MUHO compared to MHO. The expression patterns of these genes were further confirmed in hepatic and VAT samples.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Herculina Salome Kruger, Zelda De Lange-Loots, Iolanthe Marike Kruger, Marlien Pieters
Summary: Obesity is associated with increased cardiometabolic risk, but some individuals can maintain metabolically healthy obesity (MHO). A study found that about half of the black South African adults with MHO maintained this state over a 10-year period, while some became metabolically unhealthy overweight/obese. The metabolic profiles of MHO individuals were similar to those with normal weight, but had some unfavorable factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Sergio Valdes, Federico Soriguer, Gemma Rojo-Martinez, Francisco J. Tinahones, Sonsoles Morcillo
Summary: This study found that DNA methylation status is associated with the stability/worsening of the MHO phenotype, identifying two potential biomarkers for transitioning to an unhealthy state and highlighting immune system-related pathways as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
An Li, Zhi Tang, Peijun Zhu, Florien van den Bosch, Yuntao Chen, Shulan Xu, Geerten-Has E. Tjakkes
Summary: This study found a correlation between periodontitis and metabolic abnormalities in overweight and obese individuals. Periodontitis increased the risk of dyslipidemia and systemic inflammation, while also decreasing the levels of serum vitamins C and D in adults with overweight and obesity.
Article
Biochemistry & Molecular Biology
Susana Rovira-Llopis, Ruben Diaz-Rua, Carmen Grau-del Valle, Francesca Iannantuoni, Zaida Abad-Jimenez, Neus Bosch-Sierra, Joaquin Panadero-Romero, Victor M. Victor, Milagros Rocha, Carlos Morillas, Celia Banuls
Summary: This study found significant differences in miRNA expression between metabolically healthy and unhealthy obese individuals, with some miRNAs associated with insulin resistance and lipid metabolism pathways, suggesting a potential role for miRNAs in metabolically healthy obesity.
Article
Pharmacology & Pharmacy
G. Farello, G. Iapadre, M. Lizzi, C. Gentile, E. Altobelli, F. Ciocca, A. Verrotti
Summary: This study investigated cardiovascular risk in obese individuals without Metabolic Syndrome (MetS) and found that both Metabolically Healthy Obese (MHO) and metabolically unhealthy obese (MUO) groups showed higher carotid intima-media thickness (cIMT) compared to controls.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Anna Di Sessa, Antonio Paride Passaro, Alberto Maria Colasante, Speranza Cioffi, Stefano Guarino, Giuseppina Rosaria Umano, Alfonso Papparella, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
Summary: The study found that obese children, especially those with metabolically unhealthy phenotype, have an increased risk of kidney damage. Homeostasis model assessment of insulin resistance (HOMA-IR) is an important predictor of kidney damage in metabolically unhealthy obese children. In metabolically healthy obese children, both HOMA-IR and uric acid are significant risk factors for kidney damage.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Cardiac & Cardiovascular Systems
Behrooz Hamzeh, Yahya Pasdar, Shima Moradi, Mitra Darbandi, Negin Rahmani, Ebrahim Shakiba, Farid Najafi
Summary: This study found that both metabolically healthy and unhealthy obesity increased the risk of hypertension incidence, with a higher risk associated with the unhealthy obesity phenotype.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Medicine, Research & Experimental
Vanu R. Ramprasath, Sijo J. Thandapilly, Shuo Yang, Anjalika Abraham, Peter J. H. Jones, Nancy Ames
Review
Endocrinology & Metabolism
You Lv, Xue Zhao, Weiying Guo, Ying Gao, Shuo Yang, Zhuo Li, Guixia Wang
JOURNAL OF DIABETES RESEARCH
(2018)
Review
Endocrinology & Metabolism
Tong Zhou, Zheng Hu, Shuo Yang, Lin Sun, Zhenxiang Yu, Guixia Wang
JOURNAL OF DIABETES RESEARCH
(2018)
Article
Infectious Diseases
Yujia Liu, Shangyuan Ye, Xianchao Xiao, Tong Zhou, Shuo Yang, Gang Wang, Chenglin Sun, Bo Zhang, Guixia Wang
INFECTION AND DRUG RESISTANCE
(2019)
Review
Endocrinology & Metabolism
Xiaojie Yuan, Jiping Wang, Shuo Yang, Mei Gao, Lingxia Cao, Xumei Li, Dongxu Hong, Suyan Tian, Chenglin Sun
NUTRITION & DIABETES
(2020)
Review
Endocrinology & Metabolism
Xiaojie Yuan, Jiping Wang, Shuo Yang, Mei Gao, Lingxia Cao, Xumei Li, Dongxu Hong, Suyan Tian, Chenglin Sun
Summary: This study systematically reviewed the effects of intermittent fasting diets on patients with metabolic syndrome. The results showed that intermittent fasting diets can improve glucose and lipid metabolism, increase insulin sensitivity, and reduce body weight and waist circumference. It may serve as an auxiliary treatment to prevent the occurrence and development of chronic diseases.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)