Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

(2020) Jeffry Adiwidjaja et al.   Frontiers in Pharmacology

Changes in perampanel levels during de‐induction: Simulations following carbamazepine discontinuation

(2020) Edgar Schuck et al.   ACTA NEUROLOGICA SCANDINAVICA

Physiologically Based Precision Dosing Approach for Drug‐Drug‐Gene Interactions: A Simvastatin Network Analysis

(2020) Jan‐Georg Wojtyniak et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of MDR1 (C3435T) Polymorphism on Resistance, Uptake, and Efflux to Antiepileptic Drugs

(2019) Xian-min Shen et al.   DNA AND CELL BIOLOGY

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex

(2018) Todd M. Conner et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of the P-glycoprotein Inducer Carbamazepine on Fexofenadine Pharmacokinetics

(2017) Satoshi Yamada et al.   THERAPEUTIC DRUG MONITORING

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease

(2015) Radka Václavíková et al.   GENE

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

(2014) Trevor N. Johnson et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Utility of Physiologically Based Absorption Modeling in Implementing Quality by Design in Drug Development

(2011) Xinyuan Zhang et al.   AAPS Journal

The transport of antiepileptic drugs by P-glycoprotein

(2011) Chunbo Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein

(2011) Chunbo Zhang et al.   EPILEPSIA

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids

(2011) Sarah Clarysse et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions

(2010) E. J. Guest et al.   DRUG METABOLISM AND DISPOSITION

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

(2010) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid

(2010) Tiina Heikkilä et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

(2010) M. Joan Taylor et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Simulating Fasted Human Intestinal Fluids: Understanding the Roles of Lecithin and Bile Acids

(2010) Erik Söderlind et al.   MOLECULAR PHARMACEUTICS

Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells

(2009) D. F. McGinnity et al.   DRUG METABOLISM AND DISPOSITION

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

(2009) Pieter Annaert et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

(2008) J. Henshall et al.   DRUG METABOLISM AND DISPOSITION

Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

(2008) M. Shou et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic Interaction Between Efavirenz and Carbamazepine After Multiple-Dose Administration in Healthy Subjects

(2008) Ping Ji et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Several major antiepileptic drugs are substrates for human P-glycoprotein

(2008) Carlos Luna-Tortós et al.   NEUROPHARMACOLOGY

Effect of P‐Glycoprotein Expression Levels on the Concentration‐Dependent Permeability of Drugs to the Cell Membrane

(2007) Yoshiyuki Shirasaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES