Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation

(2020) Julius Lukes et al.   LEUKEMIA

Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation

(2020) Yoko Nishinaka-Arai et al.   HAEMATOLOGICA

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

(2020) Gaëtan Juban et al.   HAEMATOLOGICA

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

(2019) Maurice Labuhn et al.   CANCER CELL

Chromatin occupancy and epigenetic analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis

(2019) Te Ling et al.   BLOOD

GATA1 and cooperating mutations in myeloid leukaemia of Down syndrome

(2019) Catherine Garnett et al.   IUBMB LIFE

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia

(2019) Cécile K. Lopez et al.   Cancer Discovery

GATA1s exerts developmental stage-specific effects in human hematopoiesis

(2018) Sofia Gialesaki et al.   HAEMATOLOGICA

GATA1s exerts developmental stage-specific effects in human hematopoiesis

(2018) Sofia Gialesaki et al.   HAEMATOLOGICA

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

(2018) Andrew Volk et al.   CANCER CELL

Recent advances in understanding transient abnormal myelopoiesis in Down syndrome

(2018) Kenichiro Watanabe   PEDIATRICS INTERNATIONAL

The Pattern of Malignancies in Down Syndrome and Its Potential Context With the Immune System

(2018) Daniel Satgé et al.   Frontiers in Immunology

Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells

(2017) Ying Xie et al.   STEM CELLS

The non-coding RNA landscape of human hematopoiesis and leukemia

(2017) Adrian Schwarzer et al.   Nature Communications

Low risk of solid tumors in persons with Down syndrome

(2016) Henrik Hasle et al.   GENETICS IN MEDICINE

Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities

(2016) Kimihiko Banno et al.   Cell Reports

The biology of pediatric acute megakaryoblastic leukemia

(2015) T. A. Gruber et al.   BLOOD

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

(2015) Claire Mazumdar et al.   Cell Stem Cell

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus

(2015) Marta Byrska-Bishop et al.   JOURNAL OF CLINICAL INVESTIGATION

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

(2015) Aaron D. Viny et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

(2015) Jasper Mullenders et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome

(2014) L. Shaham et al.   BLOOD

Erythro-megakaryocytic transcription factors associated with hereditary anemia

(2014) J. D. Crispino et al.   BLOOD

Genetic alterations of the cohesin complex genes in myeloid malignancies

(2014) S. Thota et al.   BLOOD

miR-99a/100 125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF  and Wnt signaling

(2014) S. Emmrich et al.   GENES & DEVELOPMENT

Transient abnormal myelopoiesis/acute megakaryoblastic leukemia diagnosed in the placenta of a stillborn Down syndrome fetus with targeted next-generation sequencing

(2014) B Federmann et al.   LEUKEMIA

LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia

(2014) Stephan Emmrich et al.   Molecular Cancer

Loss of GATA-1 full length as a cause of Diamond-Blackfan anemia phenotype

(2014) Sara Parrella et al.   PEDIATRIC BLOOD & CANCER

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies

(2014) Yasuhiro Kazuki et al.   Scientific Reports

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder

(2013) Y. Birger et al.   BLOOD

Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome

(2013) S. I. Nikolaev et al.   BLOOD

Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes

(2013) S. Malinge et al.   BLOOD

The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs

(2013) J. Takai et al.   BLOOD

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

(2013) S. Saida et al.   BLOOD

Analysis of disease-causing GATA1 mutations in murine gene complementation systems

(2013) A. E. Campbell et al.   BLOOD

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

(2013) A Maroz et al.   LEUKEMIA

The landscape of somatic mutations in Down syndrome–related myeloid disorders

(2013) Kenichi Yoshida et al.   NATURE GENETICS

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

(2012) Sébastien Malinge et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia

(2012) Vijay G. Sankaran et al.   JOURNAL OF CLINICAL INVESTIGATION

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

(2012) E. H. Bresnick et al.   NUCLEIC ACIDS RESEARCH

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

(2012) A. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

(2012) S. T. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells

(2012) G. A. MacLean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia

(2011) K. A. Alford et al.   BLOOD

Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971

(2011) A. S. Gamis et al.   BLOOD

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

(2011) S. Taoudi et al.   GENES & DEVELOPMENT

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

(2010) K. A. Alford et al.   BLOOD

Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia

(2010) R. Kanezaki et al.   BLOOD

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case

(2010) Hirohito Ishigaki et al.   HUMAN PATHOLOGY

Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells

(2010) Song Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells

(2009) M. J. Stankiewicz et al.   BLOOD

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis

(2009) Anindita Roy et al.   BRITISH JOURNAL OF HAEMATOLOGY

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

(2009) X Liu et al.   LEUKEMIA

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

(2009) Zahra Kadri et al.   PLOS BIOLOGY

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

(2008) C. L. Carmichael et al.   BLOOD

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

(2008) O. Tunstall-Pedoe et al.   BLOOD

Trisomy 21 enhances human fetal erythro-megakaryocytic development

(2008) S. T. Chou et al.   BLOOD

Activating mutations in human acute megakaryoblastic leukemia

(2008) S. Malinge et al.   BLOOD

Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis

(2008) L. Gutierrez et al.   BLOOD

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

(2008) J.-H. Klusmann et al.   BLOOD

Risk factors for early death in neonates with Down syndrome and transient leukaemia

(2008) Hideki Muramatsu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

(2008) Stephen J Loughran et al.   NATURE IMMUNOLOGY

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

(2007) G. Kirsammer et al.   BLOOD

NFAT signaling in neural development and axon growth

(2007) Tuan Nguyen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE